Detailed information of TA system TA061961

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 2521325..2521974
• Replicon: chromosome
• Accession: NZ_CP014989
• Organism: Serinicoccus hydrothermalis strain JLT9

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: SGUI_RS11735
• Protein ID: WP_083190659.1
• Coordinates: 2521325..2521723 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A1B1NEC6
• Locus tag: SGUI_RS11740
• Protein ID: WP_066640423.1
• Coordinates: 2521720..2521974 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SGUI_RS11715	2517074..2517586	+	513	WP_066640404.1	NUDIX hydrolase	-
SGUI_RS11720	2517610..2518623	+	1014	WP_066640407.1	hypothetical protein	-
SGUI_RS11725	2519837..2520313	-	477	WP_066640417.1	class I SAM-dependent methyltransferase	-
SGUI_RS11730	2520310..2521299	-	990	WP_066640420.1	NAD(P)H-quinone oxidoreductase	-
SGUI_RS11735	2521325..2521723	-	399	WP_083190659.1	type II toxin-antitoxin system VapC family toxin	Toxin
SGUI_RS11740	2521720..2521974	-	255	WP_066640423.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
SGUI_RS11745	2522007..2522471	-	465	WP_066640430.1	MarR family transcriptional regulator	-
SGUI_RS11750	2522576..2523004	+	429	WP_066640433.1	hypothetical protein	-
SGUI_RS11755	2523001..2523351	+	351	WP_066640436.1	pyridoxamine 5'-phosphate oxidase family protein	-
SGUI_RS11760	2523376..2524665	-	1290	WP_066640437.1	nucleoside transporter	-
SGUI_RS11765	2524782..2525204	+	423	WP_066640439.1	hypothetical protein	-
SGUI_RS11770	2525239..2525556	+	318	WP_066640460.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-127)

Antitoxin

• Antitoxin VapB-like (1-83)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 13933.92 Da
• Isoelectric Point: 4.4906

>T61961 WP_083190659.1 NZ_CP014989:c2521723-2521325 [Serinicoccus hydrothermalis]
VTIVLDTSAVAAVIFGEPDAETLLRVMQRAAGDLLMSAATSVEVGIIVEARQGREATQDLRLLLDRLGVDIAPLDAAQAS
IAVDAWRRFGKGRHPASLNLGDCFAYAAAQSLDAPLLFKGGDFPQTDVRSAL

Nucleotide

• Length: 399 bp

>T61961 NZ_CP014989:c2521723-2521325 [Serinicoccus hydrothermalis]
GTGACGATCGTTCTGGACACGTCGGCGGTCGCCGCCGTCATCTTCGGCGAGCCTGACGCCGAGACCCTCCTCCGAGTCAT
GCAGCGGGCCGCCGGGGACCTACTGATGAGTGCCGCGACATCCGTCGAGGTCGGCATCATCGTGGAGGCCCGGCAGGGCC
GGGAGGCGACCCAGGATCTGAGACTGCTGCTGGACCGGCTAGGGGTCGACATCGCACCGCTCGACGCTGCACAGGCGTCG
ATCGCCGTCGACGCCTGGCGCCGCTTCGGCAAGGGGCGCCACCCAGCGTCCCTCAACCTGGGTGACTGCTTCGCCTACGC
CGCCGCGCAGAGTCTCGATGCCCCGCTGCTGTTCAAGGGCGGTGACTTCCCTCAGACGGACGTCAGGTCAGCGCTGTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9198.39 Da
• Isoelectric Point: 4.9230

>AT61961 WP_066640423.1 NZ_CP014989:c2521974-2521720 [Serinicoccus hydrothermalis]
MALNIKDAETDRLARELAAATGESITVAARRAIEERLARVTALARAEKGTDELEGIIERGRRRPVIDARTPEDIVGYDEA
GLPR

Nucleotide

• Length: 255 bp

>AT61961 NZ_CP014989:c2521974-2521720 [Serinicoccus hydrothermalis]
ATGGCGCTGAACATCAAGGATGCCGAGACGGACCGATTGGCTCGAGAGCTCGCCGCCGCCACGGGCGAGTCCATCACCGT
GGCCGCGAGGCGCGCGATCGAGGAACGCCTCGCCCGGGTCACCGCTCTTGCCCGGGCCGAGAAGGGCACGGACGAGCTCG
AGGGGATCATCGAACGAGGACGTCGGCGTCCCGTGATCGACGCGCGGACGCCGGAGGACATCGTCGGCTACGACGAGGCG
GGGCTCCCCCGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A1B1NEC6