Detailed information of TA system TA061960

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-PHD
• Location: 2214855..2215518
• Replicon: chromosome
• Accession: NZ_CP014989
• Organism: Serinicoccus hydrothermalis strain JLT9

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: SGUI_RS10205
• Protein ID: WP_191090893.1
• Coordinates: 2214855..2215256 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A1B1ND98
• Locus tag: SGUI_RS10210
• Protein ID: WP_066639622.1
• Coordinates: 2215258..2215518 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SGUI_RS10170	2210232..2210681	+	450	WP_066639603.1	hypothetical protein	-
SGUI_RS10175	2210668..2211816	-	1149	WP_066639605.1	sigma-70 family RNA polymerase sigma factor	-
SGUI_RS10180	2211818..2212237	-	420	WP_066639607.1	hypothetical protein	-
SGUI_RS17700	2212386..2212640	+	255	WP_066643200.1	type II toxin-antitoxin system VapB family antitoxin	-
SGUI_RS10190	2212637..2213029	+	393	WP_066639610.1	type II toxin-antitoxin system VapC family toxin	-
SGUI_RS10195	2213052..2213606	-	555	WP_066639613.1	dihydrofolate reductase family protein	-
SGUI_RS10200	2213663..2214841	+	1179	WP_066639616.1	MFS transporter	-
SGUI_RS10205	2214855..2215256	-	402	WP_191090893.1	PIN domain-containing protein	Toxin
SGUI_RS10210	2215258..2215518	-	261	WP_066639622.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
SGUI_RS10215	2215619..2216614	+	996	WP_066643205.1	GTP pyrophosphokinase	-
SGUI_RS10220	2216640..2217677	+	1038	WP_066639624.1	zinc-dependent alcohol dehydrogenase family protein	-
SGUI_RS10225	2217729..2218127	+	399	WP_066639633.1	VOC family protein	-
SGUI_RS10230	2218263..2219285	+	1023	WP_083190625.1	serine hydrolase	-
SGUI_RS10235	2219282..2219800	-	519	WP_066639635.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-124)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-46)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14247.26 Da
• Isoelectric Point: 4.4641

>T61960 WP_191090893.1 NZ_CP014989:c2215256-2214855 [Serinicoccus hydrothermalis]
VASRRALVDTSVWISGELGRPVDRDLLPEEAAVCVVTVAELQAGVLAAGDSVSRSRRLDTLHVALDAEVLPIDTRAAQVW
AELRVRLRDAGQRMNVNDLWIASVAVSHGLALVTQDDDFAVLAELGAVDVIKV

Nucleotide

• Length: 402 bp

>T61960 NZ_CP014989:c2215256-2214855 [Serinicoccus hydrothermalis]
GTGGCTTCAAGGCGTGCTCTGGTCGACACCAGCGTCTGGATCTCCGGCGAGCTGGGCCGACCAGTGGACCGCGACCTGCT
CCCTGAGGAGGCCGCGGTGTGCGTGGTCACCGTGGCGGAGCTGCAGGCCGGCGTGCTCGCCGCTGGTGACAGCGTGTCGC
GCTCCCGCCGGCTGGACACGCTGCACGTCGCGCTCGACGCGGAGGTCCTGCCGATCGACACGAGGGCCGCACAGGTCTGG
GCCGAGCTGCGGGTGCGACTGCGCGACGCCGGTCAGCGGATGAACGTCAACGATCTGTGGATCGCCTCGGTCGCCGTGAG
CCACGGCCTTGCCCTGGTCACCCAGGACGACGACTTCGCCGTCCTGGCCGAGCTCGGAGCCGTTGACGTCATCAAGGTGT
GA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9541.69 Da
• Isoelectric Point: 5.0878

>AT61960 WP_066639622.1 NZ_CP014989:c2215518-2215258 [Serinicoccus hydrothermalis]
MPTIASRDLRNHTSSVLAEVGRGEVYTVTVHGRPVAELRRVQAQRRPGIPREDLVALLDRQQPDPSLAEDLAWITEGSTD
DLRGLD

Nucleotide

• Length: 261 bp

>AT61960 NZ_CP014989:c2215518-2215258 [Serinicoccus hydrothermalis]
ATGCCGACGATCGCCTCGCGGGACCTGCGCAACCACACCTCGAGCGTCCTGGCCGAGGTGGGTCGGGGCGAGGTCTACAC
CGTCACCGTTCACGGACGGCCGGTCGCCGAGCTGCGGCGGGTCCAGGCGCAGCGCCGTCCGGGCATACCCCGCGAGGACC
TGGTCGCCCTCCTCGACCGCCAGCAGCCGGACCCGAGCCTGGCGGAGGACCTGGCCTGGATCACCGAGGGCAGCACCGAC
GACCTCCGCGGGCTCGACTGA

Structures

Antitoxin

• AlphaFold DB: A0A1B1ND98