Detailed information of TA system TA061959

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 2212386..2213029
• Replicon: chromosome
• Accession: NZ_CP014989
• Organism: Serinicoccus hydrothermalis strain JLT9

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A1B1ND82
• Locus tag: SGUI_RS10190
• Protein ID: WP_066639610.1
• Coordinates: 2212637..2213029 (+)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: SGUI_RS17700
• Protein ID: WP_066643200.1
• Coordinates: 2212386..2212640 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SGUI_RS10160	2208197..2209309	-	1113	WP_066639599.1	phospho-N-acetylmuramoyl-pentapeptide- transferase	-
SGUI_RS10165	2209416..2210189	+	774	WP_202816577.1	alpha/beta fold hydrolase	-
SGUI_RS10170	2210232..2210681	+	450	WP_066639603.1	hypothetical protein	-
SGUI_RS10175	2210668..2211816	-	1149	WP_066639605.1	sigma-70 family RNA polymerase sigma factor	-
SGUI_RS10180	2211818..2212237	-	420	WP_066639607.1	hypothetical protein	-
SGUI_RS17700	2212386..2212640	+	255	WP_066643200.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
SGUI_RS10190	2212637..2213029	+	393	WP_066639610.1	type II toxin-antitoxin system VapC family toxin	Toxin
SGUI_RS10195	2213052..2213606	-	555	WP_066639613.1	dihydrofolate reductase family protein	-
SGUI_RS10200	2213663..2214841	+	1179	WP_066639616.1	MFS transporter	-
SGUI_RS10205	2214855..2215256	-	402	WP_191090893.1	PIN domain-containing protein	-
SGUI_RS10210	2215258..2215518	-	261	WP_066639622.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
SGUI_RS10215	2215619..2216614	+	996	WP_066643205.1	GTP pyrophosphokinase	-
SGUI_RS10220	2216640..2217677	+	1038	WP_066639624.1	zinc-dependent alcohol dehydrogenase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• Antitoxin VapB-like (1-83)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 13997.01 Da
• Isoelectric Point: 4.7453

>T61959 WP_066639610.1 NZ_CP014989:2212637-2213029 [Serinicoccus hydrothermalis]
VIVDTSAIVAILRDEPERPAILAALAGAPAARMSTGTRLELAIVIRRLEDPVVERRVEDLLEALRITVEPFTVAQGAVAQ
RAFADFGRGSGHPARLNFGDCFAYALARESGEPLLFKGDDFTHTDLTPAL

Nucleotide

• Length: 393 bp

>T61959 NZ_CP014989:2212637-2213029 [Serinicoccus hydrothermalis]
GTGATCGTCGACACCTCCGCGATCGTGGCGATCCTGCGGGACGAGCCCGAGCGGCCCGCGATCCTCGCCGCGCTCGCCGG
GGCGCCGGCAGCACGTATGTCCACCGGGACGCGGTTGGAGCTGGCCATCGTCATCCGGCGGCTTGAGGACCCGGTCGTGG
AGCGGCGCGTCGAGGATCTCCTGGAGGCGCTGCGCATCACGGTCGAGCCGTTCACCGTCGCCCAAGGCGCCGTCGCGCAG
CGGGCCTTCGCAGACTTCGGCCGGGGGAGCGGACACCCGGCTCGACTCAACTTCGGTGACTGCTTCGCGTATGCCCTCGC
CCGCGAGAGCGGCGAGCCGCTGCTCTTCAAGGGTGACGACTTCACGCATACCGACCTCACGCCGGCTCTGTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9208.34 Da
• Isoelectric Point: 5.0071

>AT61959 WP_066643200.1 NZ_CP014989:2212386-2212640 [Serinicoccus hydrothermalis]
MSLNIKNPRVHDLARQAAARTGRSQTSVIELALRQLLDGLPTEDVASGRTRVDAILADLDLHLGRHDLTLLDHDDLYDDA
GLPT

Nucleotide

• Length: 255 bp

>AT61959 NZ_CP014989:2212386-2212640 [Serinicoccus hydrothermalis]
ATGAGCCTGAACATCAAGAATCCGCGTGTACACGACCTCGCGCGGCAGGCGGCGGCCCGCACCGGACGTTCCCAGACCAG
CGTCATCGAGCTCGCCCTCCGACAACTCCTCGACGGGCTGCCGACGGAGGACGTCGCGAGCGGTAGGACCCGCGTCGACG
CGATCCTGGCCGATCTGGACCTCCACCTGGGTCGGCACGACCTGACGTTGCTCGACCACGACGACCTCTACGACGACGCC
GGTTTGCCGACGTGA

Structures

Toxin

• AlphaFold DB: A0A1B1ND82