Detailed information of TA system TA061958

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1824737..1825422
• Replicon: chromosome
• Accession: NZ_CP014989
• Organism: Serinicoccus hydrothermalis strain JLT9

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A1B1NC70
• Locus tag: SGUI_RS17660
• Protein ID: WP_066638711.1
• Coordinates: 1824737..1825165 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A1B1NCD1
• Locus tag: SGUI_RS17665
• Protein ID: WP_066638713.1
• Coordinates: 1825168..1825422 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SGUI_RS08390	1819840..1820181	+	342	WP_066638698.1	hypothetical protein	-
SGUI_RS08395	1820210..1820719	-	510	WP_157621942.1	hypothetical protein	-
SGUI_RS08400	1820785..1821033	-	249	WP_157621783.1	hypothetical protein	-
SGUI_RS08405	1821126..1822574	+	1449	WP_066638706.1	adenylosuccinate lyase	-
SGUI_RS08410	1822571..1822936	+	366	WP_066638708.1	barstar family protein	-
SGUI_RS08415	1823152..1823517	+	366	WP_066643055.1	hypothetical protein	-
SGUI_RS08420	1823541..1824131	+	591	WP_191090885.1	MOSC domain-containing protein	-
SGUI_RS08425	1824179..1824706	-	528	WP_066643057.1	GNAT family N-acetyltransferase	-
SGUI_RS17660	1824737..1825165	-	429	WP_066638711.1	type II toxin-antitoxin system VapC family toxin	Toxin
SGUI_RS17665	1825168..1825422	-	255	WP_066638713.1	hypothetical protein	Antitoxin
SGUI_RS08440	1825504..1825791	+	288	WP_066638716.1	metal-sensitive transcriptional regulator	-
SGUI_RS08445	1825872..1826111	+	240	WP_066638719.1	heavy-metal-associated domain-containing protein	-
SGUI_RS08450	1826167..1828383	+	2217	WP_066638720.1	cadmium-translocating P-type ATPase	-
SGUI_RS08455	1828494..1829009	+	516	WP_066638721.1	hypothetical protein	-
SGUI_RS08460	1829137..1829784	-	648	WP_066643059.1	VOC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-133)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15045.11 Da
• Isoelectric Point: 6.1231

>T61958 WP_066638711.1 NZ_CP014989:c1825165-1824737 [Serinicoccus hydrothermalis]
VLVVDTNVLVYAAHVGSAHHAVTARWLEDTVKGPQVLAVPWVAALGFLRITTNPRVFAEPFTTDEALTALDAWLAHPGVT
VPQPTTRHPQVLAGLLRESGTAGNLTTDAHIAALAVEHGAEVATFDRDFARFGVRVVVPGEG

Nucleotide

• Length: 429 bp

>T61958 NZ_CP014989:c1825165-1824737 [Serinicoccus hydrothermalis]
GTGCTCGTCGTCGACACCAACGTGTTGGTCTATGCCGCCCACGTCGGCTCCGCGCACCACGCGGTCACGGCGCGCTGGCT
GGAGGACACGGTGAAGGGTCCACAGGTCCTGGCGGTGCCGTGGGTCGCGGCCCTCGGCTTCCTGCGCATCACGACCAACC
CGAGGGTCTTCGCCGAGCCGTTCACGACCGATGAGGCACTGACTGCCCTCGACGCCTGGCTCGCGCACCCCGGGGTCACG
GTCCCGCAGCCCACCACTCGTCACCCGCAGGTGCTCGCGGGACTGCTGCGGGAGTCGGGGACGGCAGGCAATCTCACGAC
CGACGCCCACATCGCCGCGCTCGCCGTGGAGCACGGAGCTGAGGTGGCGACCTTCGACCGCGACTTCGCGCGCTTCGGAG
TCCGCGTGGTCGTGCCTGGTGAGGGCTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9091.38 Da
• Isoelectric Point: 4.8283

>AT61958 WP_066638713.1 NZ_CP014989:c1825422-1825168 [Serinicoccus hydrothermalis]
MRTTITLDPDVAALVEREMAARDIRFKQAVNDALRRQLGGEAGVRPLVVPARDLGPVSVDLGGANRVADELEDEALVRKL
AEGR

Nucleotide

• Length: 255 bp

>AT61958 NZ_CP014989:c1825422-1825168 [Serinicoccus hydrothermalis]
ATGCGTACCACGATCACCCTCGACCCCGACGTCGCGGCCCTGGTCGAGCGGGAGATGGCCGCTCGCGACATCCGGTTCAA
GCAGGCTGTCAACGACGCCTTGCGTCGGCAGCTCGGTGGCGAGGCAGGTGTCCGACCCCTGGTCGTCCCCGCCCGGGATC
TCGGCCCGGTCTCGGTCGATCTCGGAGGAGCGAACCGCGTGGCCGACGAGCTGGAGGACGAGGCGCTGGTGCGCAAGCTG
GCCGAAGGGCGCTGA

Structures

Toxin

• AlphaFold DB: A0A1B1NC70

Antitoxin

• AlphaFold DB: A0A1B1NCD1