Detailed information of TA system TA061956

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1313469..1314145
• Replicon: chromosome
• Accession: NZ_CP014989
• Organism: Serinicoccus hydrothermalis strain JLT9

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: SGUI_RS06040
• Protein ID: WP_066637543.1
• Coordinates: 1313469..1313897 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A1B1NAY0
• Locus tag: SGUI_RS06045
• Protein ID: WP_066637546.1
• Coordinates: 1313894..1314145 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SGUI_RS06020	1308881..1310329	-	1449	WP_066637536.1	hemolysin family protein	-
SGUI_RS06025	1310475..1312046	-	1572	WP_157621751.1	inorganic phosphate transporter	-
SGUI_RS17630	1312123..1312260	+	138	WP_191090953.1	hypothetical protein	-
SGUI_RS06030	1312257..1312634	+	378	WP_066637538.1	type II toxin-antitoxin system VapC family toxin	-
SGUI_RS06035	1312628..1313455	-	828	WP_066637540.1	glutamate racemase	-
SGUI_RS06040	1313469..1313897	-	429	WP_066637543.1	PIN domain-containing protein	Toxin
SGUI_RS06045	1313894..1314145	-	252	WP_066637546.1	hypothetical protein	Antitoxin
SGUI_RS06050	1314177..1314956	-	780	WP_066637549.1	fumarylacetoacetate hydrolase family protein	-
SGUI_RS06055	1314988..1315314	-	327	WP_066642902.1	multidrug efflux SMR transporter	-
SGUI_RS06060	1315535..1316377	+	843	WP_157621938.1	3-methyladenine DNA glycosylase	-
SGUI_RS06065	1316387..1317487	-	1101	WP_066637555.1	branched-chain amino acid aminotransferase	-
SGUI_RS06070	1317781..1318578	+	798	WP_066637558.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-134)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15462.55 Da
• Isoelectric Point: 5.4931

>T61956 WP_066637543.1 NZ_CP014989:c1313897-1313469 [Serinicoccus hydrothermalis]
MIVPDVNVLLYAHVDAFPEHDRARTWWEETLSAGRPVGLAPVVVFGFIRIATSRRVLTRPFSVQQAQAVVESWLAQPGVH
ILDSGREHLNRTLEVLAGVGTAAALTTDAQIAAHAFIESAAVATHDTDFGRFAELDVVDPVR

Nucleotide

• Length: 429 bp

>T61956 NZ_CP014989:c1313897-1313469 [Serinicoccus hydrothermalis]
ATGATCGTCCCCGATGTCAATGTCCTCCTCTATGCGCACGTCGATGCCTTCCCGGAGCACGACCGAGCCCGTACGTGGTG
GGAGGAGACCTTGTCGGCGGGCCGGCCCGTGGGCCTGGCGCCCGTCGTCGTGTTCGGCTTCATCCGCATCGCGACCAGCC
GTCGCGTGCTCACCCGACCGTTCAGCGTCCAGCAGGCGCAGGCCGTCGTCGAGTCGTGGCTCGCTCAGCCAGGCGTCCAT
ATCCTGGACAGCGGGAGAGAACACCTCAACCGCACGCTCGAGGTCCTGGCGGGGGTCGGCACGGCCGCGGCGCTGACCAC
GGACGCCCAGATCGCCGCCCACGCCTTCATCGAGAGTGCTGCGGTCGCGACGCACGACACCGATTTCGGCCGCTTCGCCG
AACTGGACGTCGTGGACCCGGTCCGATGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9505.76 Da
• Isoelectric Point: 6.4832

>AT61956 WP_066637546.1 NZ_CP014989:c1314145-1313894 [Serinicoccus hydrothermalis]
MRTTLTLDADVVRLLEQAVHDRRTSMKSVVNDALRQALRPAQAPRPYRVDVHHSELVVGVDPARLNELADELEDETIVDK
RHR

Nucleotide

• Length: 252 bp

>AT61956 NZ_CP014989:c1314145-1313894 [Serinicoccus hydrothermalis]
ATGAGGACCACGCTGACCCTGGACGCGGACGTGGTCCGGCTGCTCGAGCAGGCCGTCCATGACCGGCGGACCTCCATGAA
GAGCGTCGTCAACGACGCCCTGCGGCAGGCCCTTCGACCAGCGCAGGCTCCCCGCCCCTACCGCGTCGACGTGCACCACA
GTGAGCTGGTGGTCGGGGTCGACCCAGCACGACTGAACGAGCTCGCCGACGAGCTGGAGGACGAGACGATCGTGGACAAG
CGCCACCGATGA

Structures

Antitoxin

• AlphaFold DB: A0A1B1NAY0