Detailed information of TA system TA061953

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 20096..20621
• Replicon: plasmid pSTY1-H2662
• Accession: NZ_CP014980
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium str. CDC H2662

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: AX03_RS25160
• Protein ID: WP_001159863.1
• Coordinates: 20316..20621 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: AX03_RS25155
• Protein ID: WP_000813641.1
• Coordinates: 20096..20314 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AX03_RS25120	15383..15764	+	382	Protein_20	YgiW/YdeI family stress tolerance OB fold protein	-
AX03_RS25940	15933..16377	+	445	Protein_21	site-specific integrase	-
AX03_RS25135	16636..17625	-	990	WP_001527061.1	RepB family plasmid replication initiator protein	-
AX03_RS25140	18119..18415	-	297	WP_001687482.1	hypothetical protein	-
AX03_RS25150	18899..19420	-	522	WP_010999942.1	hypothetical protein	-
AX03_RS25155	20096..20314	+	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
AX03_RS25160	20316..20621	+	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
AX03_RS25165	20623..20913	+	291	WP_001266176.1	hypothetical protein	-
AX03_RS25170	20910..21431	+	522	WP_000198608.1	hypothetical protein	-
AX03_RS25175	21466..22248	+	783	WP_000082169.1	site-specific integrase	-
AX03_RS25180	22257..22970	+	714	Protein_30	EAL domain-containing protein	-
AX03_RS25190	22974..23483	+	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
AX03_RS25195	23477..23962	+	486	WP_000905606.1	membrane protein	-
AX03_RS25945	24239..24526	-	288	WP_071530243.1	hypothetical protein	-
AX03_RS25200	24682..25242	+	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..94034	94034

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-119)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 13091.77 Da
• Isoelectric Point: 12.8043

>T61953 WP_001159863.1 NZ_CP014980:20316-20621 [Salmonella enterica subsp. enterica serovar Typhimurium str. CDC]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 306 bp

>T61953 NZ_CP014980:20316-20621 [Salmonella enterica subsp. enterica serovar Typhimurium str. CDC]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 9374.72 Da
• Isoelectric Point: 12.6573

>AT61953 WP_000813641.1 NZ_CP014980:20096-20314 [Salmonella enterica subsp. enterica serovar Typhimurium str. CDC]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 219 bp

>AT61953 NZ_CP014980:20096-20314 [Salmonella enterica subsp. enterica serovar Typhimurium str. CDC]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6