Detailed information of TA system TA061950

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 20103..20628
• Replicon: plasmid pSTY2-1898
• Accession: NZ_CP014973
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium str. USDA-ARS-USMARC-1898 isolate ST073

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: AX01_RS24955
• Protein ID: WP_001159863.1
• Coordinates: 20323..20628 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: AX01_RS24950
• Protein ID: WP_000813641.1
• Coordinates: 20103..20321 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AX01_RS24915	15390..15771	+	382	Protein_20	YgiW/YdeI family stress tolerance OB fold protein	-
AX01_RS25860	16048..16384	+	337	Protein_21	site-specific integrase	-
AX01_RS24930	16643..17632	-	990	WP_001527061.1	RepB family plasmid replication initiator protein	-
AX01_RS24935	18126..18422	-	297	WP_001687482.1	hypothetical protein	-
AX01_RS24945	18906..19427	-	522	WP_010999942.1	hypothetical protein	-
AX01_RS24950	20103..20321	+	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
AX01_RS24955	20323..20628	+	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
AX01_RS24960	20630..20920	+	291	WP_001266176.1	hypothetical protein	-
AX01_RS24965	20917..21438	+	522	WP_000198608.1	hypothetical protein	-
AX01_RS24970	21473..22255	+	783	WP_000082169.1	site-specific integrase	-
AX01_RS24975	22264..22977	+	714	Protein_30	EAL domain-containing protein	-
AX01_RS24985	22981..23490	+	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
AX01_RS24990	23484..23969	+	486	WP_000905606.1	membrane protein	-
AX01_RS25865	24246..24533	-	288	WP_071530243.1	hypothetical protein	-
AX01_RS24995	24689..25249	+	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..93960	93960

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 13091.77 Da
• Isoelectric Point: 12.8043

>T61950 WP_001159863.1 NZ_CP014973:20323-20628 [Salmonella enterica subsp. enterica serovar Typhimurium str.]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 306 bp

>T61950 NZ_CP014973:20323-20628 [Salmonella enterica subsp. enterica serovar Typhimurium str.]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 9374.72 Da
• Isoelectric Point: 12.6573

>AT61950 WP_000813641.1 NZ_CP014973:20103-20321 [Salmonella enterica subsp. enterica serovar Typhimurium str.]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 219 bp

>AT61950 NZ_CP014973:20103-20321 [Salmonella enterica subsp. enterica serovar Typhimurium str.]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6