Detailed information of TA system TA061949

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 2386..2897
• Replicon: plasmid pSTY1-1898
• Accession: NZ_CP014972
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium str. USDA-ARS-USMARC-1898 isolate ST073

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: AX01_RS24220
• Protein ID: WP_047656545.1
• Coordinates: 2670..2897 (+)
• Length: 76 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C1J8K5
• Locus tag: AX01_RS24215
• Protein ID: WP_001178089.1
• Coordinates: 2386..2670 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AX01_RS24200	456..1487	+	1032	WP_063320156.1	replication initiation protein	-
AX01_RS24215	2386..2670	+	285	WP_001178089.1	ribbon-helix-helix protein, CopG family	Antitoxin
AX01_RS24220	2670..2897	+	228	WP_047656545.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AX01_RS25910	2884..3150	-	267	WP_021576094.1	hypothetical protein	-
AX01_RS24230	3155..3655	-	501	WP_024230392.1	hypothetical protein	-
AX01_RS24235	3711..4313	-	603	WP_063320157.1	proQ/FINO family protein	-
AX01_RS24245	4667..6013	+	1347	WP_063320158.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..95780	95780

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-101)

Antitoxin

• Post-segregation antitoxin CcdA (8-78)

Sequences

Toxin

Protein

• Length: 76 a.a.
• Molecular weight: 9759.25 Da
• Isoelectric Point: 12.6750

>T61949 WP_047656545.1 NZ_CP014972:2670-2897 [Salmonella enterica subsp. enterica serovar Typhimurium str.]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 228 bp

>T61949 NZ_CP014972:2670-2897 [Salmonella enterica subsp. enterica serovar Typhimurium str.]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 12194.55 Da
• Isoelectric Point: 12.7731

>AT61949 WP_001178089.1 NZ_CP014972:2386-2670 [Salmonella enterica subsp. enterica serovar Typhimurium str.]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKK

Nucleotide

• Length: 285 bp

>AT61949 NZ_CP014972:2386-2670 [Salmonella enterica subsp. enterica serovar Typhimurium str.]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Antitoxin

• AlphaFold DB: A0A731IHA8