Detailed information of TA system TA061948

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 20100..20625
• Replicon: plasmid pSTY1-1808
• Accession: NZ_CP014970
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium str. USDA-ARS-USMARC-1808 isolate ST1126-1

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: AW93_RS24140
• Protein ID: WP_001159863.1
• Coordinates: 20320..20625 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: AW93_RS24135
• Protein ID: WP_000813641.1
• Coordinates: 20100..20318 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AW93_RS24110	15387..15768	+	382	Protein_20	YgiW/YdeI family stress tolerance OB fold protein	-
AW93_RS26985	16045..16381	+	337	Protein_21	site-specific integrase	-
AW93_RS24120	16640..17629	-	990	WP_001527061.1	RepB family plasmid replication initiator protein	-
AW93_RS26560	18123..18419	-	297	WP_001687482.1	hypothetical protein	-
AW93_RS24130	18903..19424	-	522	WP_010999942.1	hypothetical protein	-
AW93_RS24135	20100..20318	+	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
AW93_RS24140	20320..20625	+	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
AW93_RS24145	20627..20917	+	291	WP_001266176.1	hypothetical protein	-
AW93_RS24150	20914..21435	+	522	WP_000198608.1	hypothetical protein	-
AW93_RS24155	21470..22252	+	783	WP_000082169.1	site-specific integrase	-
AW93_RS24160	22261..22974	+	714	Protein_30	EAL domain-containing protein	-
AW93_RS24165	22978..23487	+	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
AW93_RS24170	23481..23966	+	486	WP_000905606.1	membrane protein	-
AW93_RS27160	24243..24530	-	288	WP_071530243.1	hypothetical protein	-
AW93_RS24180	24686..25246	+	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..94014	94014

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (8-64)

Antitoxin

• Biofilm formation regulator YbaJ (1-118)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 13091.77 Da
• Isoelectric Point: 12.8043

>T61948 WP_001159863.1 NZ_CP014970:20320-20625 [Salmonella enterica subsp. enterica serovar Typhimurium str.]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 306 bp

>T61948 NZ_CP014970:20320-20625 [Salmonella enterica subsp. enterica serovar Typhimurium str.]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 9374.72 Da
• Isoelectric Point: 12.6573

>AT61948 WP_000813641.1 NZ_CP014970:20100-20318 [Salmonella enterica subsp. enterica serovar Typhimurium str.]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 219 bp

>AT61948 NZ_CP014970:20100-20318 [Salmonella enterica subsp. enterica serovar Typhimurium str.]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6