Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/GNAT-DUF1778
Location 1068950..1069713 Replicon chromosome
Accession NZ_CP014957
Organism Mycobacteroides abscessus strain FLAC031

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag A3O02_RS05260 Protein ID WP_086361399.1
Coordinates 1068950..1069408 (-) Length 153 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag A3O02_RS05265 Protein ID WP_053082894.1
Coordinates 1069444..1069713 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A3O02_RS05240 1065561..1066193 + 633 WP_023363553.1 class I SAM-dependent methyltransferase -
A3O02_RS05245 1066383..1066979 - 597 WP_023363551.1 ABATE domain-containing protein -
A3O02_RS05250 1067080..1067649 + 570 WP_023363549.1 TIGR03086 family protein -
A3O02_RS05255 1067685..1068554 + 870 WP_052622775.1 pyridoxamine 5'-phosphate oxidase family protein -
A3O02_RS05260 1068950..1069408 - 459 WP_086361399.1 GNAT family N-acetyltransferase Toxin
A3O02_RS05265 1069444..1069713 - 270 WP_053082894.1 DUF1778 domain-containing protein Antitoxin
A3O02_RS05270 1070165..1070638 + 474 WP_005082966.1 MarR family transcriptional regulator -
A3O02_RS05275 1070646..1072061 + 1416 WP_052618104.1 hypothetical protein -
A3O02_RS05280 1072066..1073160 - 1095 WP_025089030.1 DUF2236 domain-containing protein -
A3O02_RS05285 1073247..1073849 + 603 WP_005082962.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(30-131)

Antitoxin

Vibrio phage ICP1, Orf50

(9-82)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 16886.44 Da        Isoelectric Point: 10.2690

>T61946 WP_086361399.1 NZ_CP014957:c1069408-1068950 [Mycobacteroides abscessus]
IVDDFDCGNDVLNEWLRTKALHNQREGGSRTWVVLDGRRVVAFYASSTAVLMRSRATKRAARNQPDPLPAVLLGRLAVDA
NHQGRGLAAALLKHFILKSLEVAELTGVRLLLVHANNDTARRFYLRYGFEPSPVDDLTLMLLVKDVRPSPSA

Download         Length: 459 bp

>T61946 NZ_CP014957:c1069408-1068950 [Mycobacteroides abscessus]
ATCGTCGACGACTTCGACTGCGGCAACGACGTGCTCAACGAGTGGCTGCGGACGAAGGCTCTGCACAATCAGCGCGAAGG
AGGCAGCCGCACCTGGGTGGTGCTGGACGGGCGACGGGTGGTGGCCTTCTATGCCTCCAGCACGGCGGTGCTCATGCGCA
GCCGGGCGACGAAACGCGCTGCTCGCAATCAGCCGGACCCGTTACCTGCGGTCCTGCTCGGCCGGCTGGCCGTCGACGCG
AACCATCAAGGGCGTGGTCTCGCTGCAGCACTTCTCAAACATTTCATCCTCAAGTCACTTGAGGTCGCGGAGCTGACGGG
GGTTCGGCTGCTGCTGGTCCACGCAAACAACGACACCGCCCGGCGCTTCTACTTGCGCTACGGTTTTGAGCCTTCTCCTG
TCGACGACCTAACACTGATGCTCCTCGTAAAGGACGTCCGGCCCAGCCCATCTGCGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9925.25 Da        Isoelectric Point: 5.6845

>AT61946 WP_053082894.1 NZ_CP014957:c1069713-1069444 [Mycobacteroides abscessus]
VETKSGRWHLRVTAAQDAVVRRVLDVTGESLNDYVVRHAVQAAEADLADRRVFVLDDAAWTDLQALLDRPPSPKPELARL
LANPSILER

Download         Length: 270 bp

>AT61946 NZ_CP014957:c1069713-1069444 [Mycobacteroides abscessus]
GTGGAGACGAAGAGTGGTCGCTGGCACCTGCGCGTGACCGCGGCGCAAGATGCGGTGGTGCGACGTGTGCTCGACGTCAC
GGGCGAGTCGCTCAACGACTATGTGGTGCGTCACGCCGTTCAGGCCGCCGAGGCCGACCTCGCTGATCGGAGAGTGTTCG
TCCTCGATGACGCCGCCTGGACCGATCTTCAGGCGCTGCTCGACCGTCCGCCAAGCCCCAAGCCCGAGTTGGCGCGCCTG
CTGGCGAATCCGTCGATTTTGGAACGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References