Detailed information of TA system TA061913

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 142146..142651
• Replicon: chromosome
• Accession: NZ_CP014948
• Organism: Pseudomonas aeruginosa strain N17-1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: OB07_RS00640
• Protein ID: WP_003083773.1
• Coordinates: 142146..142427 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q9I707
• Locus tag: OB07_RS00645
• Protein ID: WP_003112628.1
• Coordinates: 142424..142651 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OB07_RS00615	137397..138746	+	1350	WP_003119513.1	C4-dicarboxylate transporter DctA	-
OB07_RS00620	138795..139481	+	687	WP_003083762.1	FadR family transcriptional regulator	-
OB07_RS00625	139582..140316	+	735	WP_003117208.1	GntR family transcriptional regulator	-
OB07_RS00630	140520..140906	+	387	WP_014602345.1	aegerolysin family protein	-
OB07_RS00635	140938..141846	-	909	WP_003083769.1	LysR family transcriptional regulator	-
OB07_RS00640	142146..142427	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
OB07_RS00645	142424..142651	-	228	WP_003112628.1	CopG family ribbon-helix-helix protein	Antitoxin
OB07_RS00650	142827..143447	-	621	WP_003101226.1	hypothetical protein	-
OB07_RS00655	143548..144048	+	501	WP_003112629.1	LEA type 2 family protein	-
OB07_RS00660	144121..144462	+	342	WP_003101229.1	alkylphosphonate utilization protein	-
OB07_RS00665	144544..145971	-	1428	WP_003083784.1	GABA permease	-
OB07_RS00670	146140..147633	-	1494	WP_003101230.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T61913 WP_003083773.1 NZ_CP014948:c142427-142146 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T61913 NZ_CP014948:c142427-142146 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCTATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGAAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8568.64 Da
• Isoelectric Point: 5.5740

>AT61913 WP_003112628.1 NZ_CP014948:c142651-142424 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT61913 NZ_CP014948:c142651-142424 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAAAAGCGCTGGGGGCTGCAATGA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: Q9I707