Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 5970563..5971088 Replicon chromosome
Accession NZ_CP014947
Organism Pseudomonas koreensis strain D26

Toxin (Protein)


Gene name relE Uniprot ID A0A554AGI8
Locus tag AYO71_RS26850 Protein ID WP_041477706.1
Coordinates 5970792..5971088 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A6I4K355
Locus tag AYO71_RS26845 Protein ID WP_039761862.1
Coordinates 5970563..5970802 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYO71_RS26820 5966346..5966807 + 462 WP_016773002.1 GNAT family N-acetyltransferase -
AYO71_RS26825 5967067..5967717 + 651 WP_016773001.1 DedA family protein -
AYO71_RS26830 5967722..5968534 + 813 WP_041477708.1 zinc-dependent peptidase -
AYO71_RS26835 5968647..5969174 + 528 WP_003205933.1 inorganic diphosphatase -
AYO71_RS26840 5969392..5970138 + 747 WP_041477707.1 helix-turn-helix transcriptional regulator -
AYO71_RS26845 5970563..5970802 + 240 WP_039761862.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AYO71_RS26850 5970792..5971088 + 297 WP_041477706.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AYO71_RS26855 5971237..5972322 + 1086 WP_041477704.1 macro domain-containing protein -
AYO71_RS26860 5972368..5973180 - 813 WP_041477703.1 DUF2135 domain-containing protein -
AYO71_RS26865 5973184..5974803 - 1620 WP_041477702.1 DUF2300 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-81)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11667.51 Da        Isoelectric Point: 9.6904

>T61911 WP_041477706.1 NZ_CP014947:5970792-5971088 [Pseudomonas koreensis]
MTYELEFDRRALKEWNKLGDTVRQQFKKKLAEVLENPRIEANRLRELPDCYKVKLKSAGYRLIYQVLDHEILVFVVAIGK
REREAAYEVAQDRLPSRT

Download         Length: 297 bp

>T61911 NZ_CP014947:5970792-5971088 [Pseudomonas koreensis]
ATGACTTATGAGCTTGAGTTTGATCGACGTGCGTTAAAAGAGTGGAACAAGCTGGGCGATACGGTTCGCCAACAGTTCAA
AAAAAAACTGGCTGAGGTCTTGGAGAATCCTCGAATCGAAGCCAATCGGCTTCGCGAGCTACCAGACTGCTATAAAGTGA
AATTGAAAAGCGCCGGTTATCGCTTGATCTATCAGGTACTTGATCACGAAATCCTGGTGTTCGTGGTCGCCATAGGCAAA
CGTGAGCGGGAGGCAGCCTACGAGGTTGCGCAAGATCGCTTGCCATCCCGGACCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8853.19 Da        Isoelectric Point: 4.6017

>AT61911 WP_039761862.1 NZ_CP014947:5970563-5970802 [Pseudomonas koreensis]
MASINIRIDDDLKQRSFAELEKLGVTPSELLRQTLQYVAERGKLPFKAALLSEEDEALIAVVTERLASPQRVKVSLDDL

Download         Length: 240 bp

>AT61911 NZ_CP014947:5970563-5970802 [Pseudomonas koreensis]
ATGGCTTCCATCAACATCCGCATCGATGATGATCTGAAACAGCGCTCATTCGCAGAACTCGAAAAGCTCGGCGTCACGCC
GTCGGAGCTTCTGCGCCAAACCCTCCAATATGTAGCAGAGCGAGGCAAGTTACCCTTCAAAGCGGCGCTGCTCAGTGAAG
AGGATGAAGCGCTGATTGCCGTAGTCACCGAACGTCTCGCATCCCCTCAGCGGGTCAAGGTGAGTCTGGATGACTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A554AGI8

Antitoxin

Source ID Structure
AlphaFold DB A0A6I4K355

References