Detailed information of TA system TA061905

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2439538..2440154
• Replicon: chromosome
• Accession: NZ_CP014947
• Organism: Pseudomonas koreensis strain D26

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: AYO71_RS10830
• Protein ID: WP_041479616.1
• Coordinates: 2439538..2439750 (+)
• Length: 71 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: V8RA99
• Locus tag: AYO71_RS10835
• Protein ID: WP_016771035.1
• Coordinates: 2439750..2440154 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AYO71_RS10800	2435640..2436176	+	537	WP_016771042.1	DsbE family thiol:disulfide interchange protein	-
AYO71_RS10805	2436173..2436643	+	471	WP_041479621.1	cytochrome c-type biogenesis protein CcmH	-
AYO71_RS10810	2436640..2437839	+	1200	WP_041479620.1	c-type cytochrome biogenesis protein CcmI	-
AYO71_RS10815	2437865..2438269	+	405	WP_041479619.1	hypothetical protein	-
AYO71_RS10820	2438314..2438889	-	576	WP_041479618.1	PIN domain-containing protein	-
AYO71_RS10825	2438886..2439353	-	468	WP_041479617.1	helix-turn-helix domain-containing protein	-
AYO71_RS10830	2439538..2439750	+	213	WP_041479616.1	type II toxin-antitoxin system HicA family toxin	Toxin
AYO71_RS10835	2439750..2440154	+	405	WP_016771035.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
AYO71_RS10840	2440268..2441467	-	1200	WP_041479615.1	MFS transporter	-
AYO71_RS10845	2441634..2442632	-	999	WP_041479614.1	sulfate ABC transporter substrate-binding protein	-
AYO71_RS10850	2442823..2443647	-	825	WP_041479613.1	ion transporter	-
AYO71_RS10855	2443669..2444583	-	915	WP_041479612.1	urea transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 71 a.a.
• Molecular weight: 7960.12 Da
• Isoelectric Point: 10.5523

>T61905 WP_041479616.1 NZ_CP014947:2439538-2439750 [Pseudomonas koreensis]
VQSRLLMKELEEAGWTLDRVAGSHYIFTHRYNPNTIAVPHPKKDLPLGTVKSIRRRAGLFSPPTRHEGDP

Nucleotide

• Length: 213 bp

>T61905 NZ_CP014947:2439538-2439750 [Pseudomonas koreensis]
GTGCAGAGCAGGCTATTGATGAAGGAGCTGGAGGAGGCGGGCTGGACGCTGGATCGGGTTGCGGGCAGTCATTACATCTT
CACTCATCGTTACAACCCGAACACGATTGCCGTCCCGCATCCGAAAAAGGATTTACCGCTGGGGACAGTCAAAAGCATTC
GGCGGCGCGCGGGGTTATTCAGCCCGCCAACCCGTCATGAAGGAGATCCGTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14776.81 Da
• Isoelectric Point: 4.5789

>AT61905 WP_016771035.1 NZ_CP014947:2439750-2440154 [Pseudomonas koreensis]
MQYPICIEWGDENTAIGIQIPDIPGAVTAGDSFEEAYNAAVEVAHLMLQEIAAAGQAIPMPTSAAAHRNHPDFAEMGWGM
LELDISPYLGKTEKVNVTLPGYVIQRIDRYVREHNVKSRSSFLADAAMEKLVRY

Nucleotide

• Length: 405 bp

>AT61905 NZ_CP014947:2439750-2440154 [Pseudomonas koreensis]
ATGCAATATCCCATCTGCATCGAGTGGGGTGACGAGAACACTGCCATCGGTATTCAGATCCCCGATATTCCCGGCGCAGT
CACGGCCGGTGACAGCTTTGAGGAGGCCTACAACGCGGCCGTGGAAGTGGCTCACCTCATGCTGCAGGAGATCGCGGCGG
CCGGTCAGGCGATTCCGATGCCGACCTCGGCAGCGGCGCATCGCAATCATCCGGATTTTGCCGAGATGGGCTGGGGCATG
CTGGAGCTGGATATCTCGCCGTACCTTGGCAAGACCGAAAAGGTCAACGTTACGCTGCCCGGCTATGTGATTCAGCGTAT
TGATCGCTATGTACGCGAGCACAACGTCAAAAGCCGCTCCTCGTTTCTGGCGGATGCGGCGATGGAGAAACTGGTTCGGT
ATTGA

Structures

Antitoxin

• AlphaFold DB: A0A1N7DVA1