Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 2438314..2439353 | Replicon | chromosome |
| Accession | NZ_CP014947 | ||
| Organism | Pseudomonas koreensis strain D26 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | A0A554A8L6 |
| Locus tag | AYO71_RS10820 | Protein ID | WP_041479618.1 |
| Coordinates | 2438314..2438889 (-) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | A0A554A8M8 |
| Locus tag | AYO71_RS10825 | Protein ID | WP_041479617.1 |
| Coordinates | 2438886..2439353 (-) | Length | 156 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AYO71_RS10795 | 2433655..2435643 | + | 1989 | WP_041479622.1 | heme lyase CcmF/NrfE family subunit | - |
| AYO71_RS10800 | 2435640..2436176 | + | 537 | WP_016771042.1 | DsbE family thiol:disulfide interchange protein | - |
| AYO71_RS10805 | 2436173..2436643 | + | 471 | WP_041479621.1 | cytochrome c-type biogenesis protein CcmH | - |
| AYO71_RS10810 | 2436640..2437839 | + | 1200 | WP_041479620.1 | c-type cytochrome biogenesis protein CcmI | - |
| AYO71_RS10815 | 2437865..2438269 | + | 405 | WP_041479619.1 | hypothetical protein | - |
| AYO71_RS10820 | 2438314..2438889 | - | 576 | WP_041479618.1 | PIN domain-containing protein | Toxin |
| AYO71_RS10825 | 2438886..2439353 | - | 468 | WP_041479617.1 | helix-turn-helix domain-containing protein | Antitoxin |
| AYO71_RS10830 | 2439538..2439750 | + | 213 | WP_041479616.1 | type II toxin-antitoxin system HicA family toxin | - |
| AYO71_RS10835 | 2439750..2440154 | + | 405 | WP_016771035.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| AYO71_RS10840 | 2440268..2441467 | - | 1200 | WP_041479615.1 | MFS transporter | - |
| AYO71_RS10845 | 2441634..2442632 | - | 999 | WP_041479614.1 | sulfate ABC transporter substrate-binding protein | - |
| AYO71_RS10850 | 2442823..2443647 | - | 825 | WP_041479613.1 | ion transporter | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21617.65 Da Isoelectric Point: 6.0680
>T61904 WP_041479618.1 NZ_CP014947:c2438889-2438314 [Pseudomonas koreensis]
VRHSSFTAVYDACVLYPAPLRDFLMWLALSGLYRARWTQEVHHEWKRNLLKNRSDLTLEQLDRTSQLMDLAIPDACIDGY
EDLVSGLTLPDENDRHVLAAAIRCGADVIVTFNLKDFPSCHLAPYGIEAQHPDEFVENLFHLDSAAVVAAAQSQRRQLKT
PTVEVDKYLGFLQRQGLVESVKALGHYRAIL
VRHSSFTAVYDACVLYPAPLRDFLMWLALSGLYRARWTQEVHHEWKRNLLKNRSDLTLEQLDRTSQLMDLAIPDACIDGY
EDLVSGLTLPDENDRHVLAAAIRCGADVIVTFNLKDFPSCHLAPYGIEAQHPDEFVENLFHLDSAAVVAAAQSQRRQLKT
PTVEVDKYLGFLQRQGLVESVKALGHYRAIL
Download Length: 576 bp
>T61904 NZ_CP014947:c2438889-2438314 [Pseudomonas koreensis]
GTGAGGCATTCCTCTTTCACTGCTGTATACGATGCATGCGTTTTATATCCGGCCCCTTTAAGAGATTTCCTGATGTGGCT
CGCGTTGTCAGGGCTGTATCGGGCTCGCTGGACTCAGGAAGTACACCACGAATGGAAGCGTAACTTATTGAAGAACAGGT
CCGACCTGACCCTCGAACAACTCGATCGCACATCGCAATTGATGGACCTGGCCATTCCAGACGCGTGTATTGATGGCTAT
GAAGACTTGGTGTCAGGCCTGACGCTGCCTGATGAGAACGACCGCCATGTTCTGGCGGCCGCTATCCGATGCGGTGCCGA
TGTAATAGTGACGTTCAACCTGAAAGATTTCCCCTCCTGCCACCTCGCGCCATATGGCATCGAAGCTCAGCACCCGGATG
AGTTTGTGGAAAACCTTTTTCATCTTGATTCGGCTGCCGTCGTCGCTGCGGCTCAAAGCCAGCGACGGCAATTGAAAACG
CCCACTGTGGAGGTGGACAAATATCTCGGCTTTCTCCAGCGGCAAGGCTTGGTCGAATCGGTCAAGGCGTTAGGTCACTA
TCGTGCGATTCTCTGA
GTGAGGCATTCCTCTTTCACTGCTGTATACGATGCATGCGTTTTATATCCGGCCCCTTTAAGAGATTTCCTGATGTGGCT
CGCGTTGTCAGGGCTGTATCGGGCTCGCTGGACTCAGGAAGTACACCACGAATGGAAGCGTAACTTATTGAAGAACAGGT
CCGACCTGACCCTCGAACAACTCGATCGCACATCGCAATTGATGGACCTGGCCATTCCAGACGCGTGTATTGATGGCTAT
GAAGACTTGGTGTCAGGCCTGACGCTGCCTGATGAGAACGACCGCCATGTTCTGGCGGCCGCTATCCGATGCGGTGCCGA
TGTAATAGTGACGTTCAACCTGAAAGATTTCCCCTCCTGCCACCTCGCGCCATATGGCATCGAAGCTCAGCACCCGGATG
AGTTTGTGGAAAACCTTTTTCATCTTGATTCGGCTGCCGTCGTCGCTGCGGCTCAAAGCCAGCGACGGCAATTGAAAACG
CCCACTGTGGAGGTGGACAAATATCTCGGCTTTCTCCAGCGGCAAGGCTTGGTCGAATCGGTCAAGGCGTTAGGTCACTA
TCGTGCGATTCTCTGA
Antitoxin
Download Length: 156 a.a. Molecular weight: 17112.49 Da Isoelectric Point: 6.6488
>AT61904 WP_041479617.1 NZ_CP014947:c2439353-2438886 [Pseudomonas koreensis]
MTTATPSAINLPVEREVKAAIAGQRALSAFLTTAFETQRIQIFDEQNEAHSVELPTSALRLLSDILAALAQGNAVKVVPI
HAELTTQEAADLLNVSRPHMIKLLESGEVSYHKTGKHRRVRFADLMEYKTRRDTASEQAMTLLAEQAQALRTGYE
MTTATPSAINLPVEREVKAAIAGQRALSAFLTTAFETQRIQIFDEQNEAHSVELPTSALRLLSDILAALAQGNAVKVVPI
HAELTTQEAADLLNVSRPHMIKLLESGEVSYHKTGKHRRVRFADLMEYKTRRDTASEQAMTLLAEQAQALRTGYE
Download Length: 468 bp
>AT61904 NZ_CP014947:c2439353-2438886 [Pseudomonas koreensis]
ATGACCACCGCTACTCCATCTGCCATCAATCTGCCTGTCGAACGAGAGGTCAAAGCCGCGATTGCAGGCCAGCGCGCCCT
GAGCGCCTTCCTCACAACCGCTTTTGAAACTCAGCGAATCCAGATTTTTGATGAACAGAACGAAGCCCACAGCGTCGAGC
TGCCAACATCGGCGTTGCGCTTGCTGAGCGATATCCTCGCGGCGCTGGCGCAGGGCAACGCTGTGAAGGTGGTACCGATC
CACGCGGAGCTGACCACGCAGGAAGCTGCCGATCTGCTCAACGTCTCACGTCCGCACATGATCAAACTGCTGGAGAGCGG
TGAGGTTTCCTACCACAAAACAGGCAAGCACCGACGTGTGCGTTTTGCTGATCTGATGGAATATAAAACCCGGCGAGACA
CCGCCAGCGAGCAGGCAATGACGCTTCTCGCGGAGCAGGCACAGGCGCTAAGGACAGGATACGAGTGA
ATGACCACCGCTACTCCATCTGCCATCAATCTGCCTGTCGAACGAGAGGTCAAAGCCGCGATTGCAGGCCAGCGCGCCCT
GAGCGCCTTCCTCACAACCGCTTTTGAAACTCAGCGAATCCAGATTTTTGATGAACAGAACGAAGCCCACAGCGTCGAGC
TGCCAACATCGGCGTTGCGCTTGCTGAGCGATATCCTCGCGGCGCTGGCGCAGGGCAACGCTGTGAAGGTGGTACCGATC
CACGCGGAGCTGACCACGCAGGAAGCTGCCGATCTGCTCAACGTCTCACGTCCGCACATGATCAAACTGCTGGAGAGCGG
TGAGGTTTCCTACCACAAAACAGGCAAGCACCGACGTGTGCGTTTTGCTGATCTGATGGAATATAAAACCCGGCGAGACA
CCGCCAGCGAGCAGGCAATGACGCTTCTCGCGGAGCAGGCACAGGCGCTAAGGACAGGATACGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A554A8L6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A554A8M8 |