Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 114744..115276 Replicon chromosome
Accession NZ_CP014944
Organism Colwellia sp. PAMC 20917

Toxin (Protein)


Gene name parE Uniprot ID A0A1D8RQW3
Locus tag A3Q34_RS00550 Protein ID WP_070373588.1
Coordinates 114983..115276 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1D8RQW7
Locus tag A3Q34_RS00545 Protein ID WP_070373587.1
Coordinates 114744..114983 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A3Q34_RS00525 109833..111530 + 1698 WP_070373584.1 DUF3413 domain-containing protein -
A3Q34_RS00535 112579..113733 + 1155 WP_070373585.1 IS110 family transposase -
A3Q34_RS00540 114137..114544 - 408 WP_083278115.1 TonB family protein -
A3Q34_RS00545 114744..114983 + 240 WP_070373587.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
A3Q34_RS00550 114983..115276 + 294 WP_070373588.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A3Q34_RS00555 115485..116003 - 519 WP_070373589.1 gamma-glutamylcyclotransferase -
A3Q34_RS00560 116293..117165 - 873 WP_070373590.1 hypothetical protein -
A3Q34_RS00565 117307..117612 - 306 WP_197517629.1 IS200/IS605 family transposase -
A3Q34_RS00570 117659..118960 + 1302 WP_070373591.1 transposase -
A3Q34_RS00575 118961..119902 - 942 WP_070373592.1 PAS domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 112549..113733 1184


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Antitoxin ParD

(1-77)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11245.11 Da        Isoelectric Point: 9.5542

>T61900 WP_070373588.1 NZ_CP014944:114983-115276 [Colwellia sp. PAMC 20917]
MKKLVLSAKAKSDLIKIALYTQLTWGTTQRNDYLKILDSTFRLLAEEPELGINCDYIREGYSKYPQASHVIYYKEHKVNQ
ILIVRVLHKSMDVNSAI

Download         Length: 294 bp

>T61900 NZ_CP014944:114983-115276 [Colwellia sp. PAMC 20917]
ATGAAAAAATTAGTATTATCCGCTAAAGCGAAATCAGATTTAATTAAAATAGCTCTATACACTCAACTTACATGGGGAAC
CACGCAACGAAATGATTATTTAAAAATATTAGATAGCACATTTCGATTATTAGCTGAGGAGCCAGAGTTAGGAATAAACT
GTGATTACATCAGAGAGGGTTACAGTAAATATCCTCAAGCTAGCCACGTAATTTATTACAAAGAACATAAAGTAAATCAA
ATATTAATTGTACGTGTGCTGCATAAAAGTATGGATGTTAACTCTGCTATCTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8873.75 Da        Isoelectric Point: 4.3287

>AT61900 WP_070373587.1 NZ_CP014944:114744-114983 [Colwellia sp. PAMC 20917]
MAKNTSVTLGDHFDQFINQQLNTGRYGSASEIVRAGLRALEDQETKLLNLRNMLIQGEQSGIADYSYDSLLTELDNENH

Download         Length: 240 bp

>AT61900 NZ_CP014944:114744-114983 [Colwellia sp. PAMC 20917]
ATGGCTAAAAATACTAGCGTCACACTAGGCGATCACTTTGATCAGTTTATTAACCAACAACTTAACACAGGTCGTTACGG
TTCAGCGAGTGAAATTGTTCGAGCTGGGTTAAGAGCTTTAGAAGATCAAGAGACTAAACTATTAAATTTACGCAATATGC
TTATTCAAGGTGAACAAAGCGGTATAGCTGATTACAGTTATGATTCTTTATTAACAGAATTAGATAACGAAAATCACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D8RQW3

Antitoxin

Source ID Structure
AlphaFold DB A0A1D8RQW7

References