Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2760242..2760907 Replicon chromosome
Accession NZ_CP014924
Organism Secundilactobacillus paracollinoides strain TMW 1.1995

Toxin (Protein)


Gene name hicA Uniprot ID A0A1B2J0M7
Locus tag AYR63_RS12020 Protein ID WP_054707657.1
Coordinates 2760725..2760907 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0R1T2R3
Locus tag AYR63_RS12015 Protein ID WP_054707660.1
Coordinates 2760242..2760697 (-) Length 152 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYR63_RS12005 2756537..2757700 + 1164 WP_065903035.1 molecular chaperone DnaJ -
AYR63_RS12010 2758249..2760087 + 1839 WP_054707664.1 translation elongation factor 4 -
AYR63_RS12015 2760242..2760697 - 456 WP_054707660.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AYR63_RS12020 2760725..2760907 - 183 WP_054707657.1 type II toxin-antitoxin system HicA family toxin Toxin
AYR63_RS12025 2761034..2761945 - 912 WP_054707655.1 LysR family transcriptional regulator -
AYR63_RS12030 2762100..2764442 + 2343 WP_065903036.1 FAD-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(11-110)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6737.04 Da        Isoelectric Point: 10.9178

>T61891 WP_054707657.1 NZ_CP014924:c2760907-2760725 [Secundilactobacillus paracollinoides]
MPMTQKQMIKLLMTHGWQKTVGGKGSHVKMQKSGQRPIIVPHGELNKYTEHGIKKEAGLL

Download         Length: 183 bp

>T61891 NZ_CP014924:c2760907-2760725 [Secundilactobacillus paracollinoides]
ATGCCGATGACGCAGAAACAAATGATTAAGCTATTGATGACACACGGATGGCAAAAAACAGTGGGCGGCAAGGGCTCACA
TGTTAAGATGCAAAAGTCTGGTCAGCGACCGATTATCGTGCCCCATGGTGAGTTAAACAAATATACCGAACATGGCATCA
AAAAAGAAGCTGGTTTGTTATAA

Antitoxin


Download         Length: 152 a.a.        Molecular weight: 16948.37 Da        Isoelectric Point: 5.0817

>AT61891 WP_054707660.1 NZ_CP014924:c2760697-2760242 [Secundilactobacillus paracollinoides]
MLMTYPALFYFDPDESVPYFVHFPDFPNSATQGKTISDAMMMASDYLGITAADMLQQTHPLPAPTDINQLSLINNNPFKD
DPDFKNHYDMTKSFISMVTVDLSSYLAADKPIKKTLTIPNWADKLGKKLKLNFSQTLTDAITDISLKSGNR

Download         Length: 456 bp

>AT61891 NZ_CP014924:c2760697-2760242 [Secundilactobacillus paracollinoides]
ATGTTAATGACCTACCCCGCACTATTCTATTTTGACCCAGATGAAAGTGTCCCTTACTTTGTCCACTTCCCCGATTTTCC
TAATTCGGCGACACAGGGTAAAACCATCTCTGATGCCATGATGATGGCATCAGACTATCTCGGCATCACCGCTGCGGATA
TGTTGCAACAAACACACCCTCTGCCAGCACCAACAGACATCAATCAACTCTCACTGATCAACAATAATCCGTTTAAAGAT
GACCCAGATTTTAAGAACCATTATGATATGACAAAATCATTTATTTCAATGGTAACTGTTGATTTATCTTCTTATTTAGC
TGCCGACAAACCCATAAAAAAAACACTCACGATTCCAAACTGGGCTGACAAACTCGGTAAGAAACTTAAACTCAACTTTT
CTCAAACATTGACCGATGCGATTACTGATATTTCATTGAAGTCAGGCAATCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B2J0M7

Antitoxin

Source ID Structure
AlphaFold DB A0A0R1T2R3

References