Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 490504..491072 Replicon chromosome
Accession NZ_CP014907
Organism Fructilactobacillus lindneri strain TMW 1.481

Toxin (Protein)


Gene name relE Uniprot ID A0A0R2JSQ8
Locus tag AYR59_RS02355 Protein ID WP_054646754.1
Coordinates 490797..491072 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0R2JVQ8
Locus tag AYR59_RS02350 Protein ID WP_054646755.1
Coordinates 490504..490737 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYR59_RS02330 486213..486671 + 459 WP_054646758.1 LysR family transcriptional regulator -
AYR59_RS02335 486713..487102 + 390 WP_054646757.1 hypothetical protein -
AYR59_RS02340 487247..488623 - 1377 WP_056997739.1 amino acid permease -
AYR59_RS02345 488779..490329 - 1551 WP_065866150.1 multicopper oxidase domain-containing protein -
AYR59_RS02350 490504..490737 + 234 WP_054646755.1 antitoxin Antitoxin
AYR59_RS02355 490797..491072 + 276 WP_054646754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AYR59_RS02360 491144..491740 + 597 WP_054646753.1 DUF1054 family protein -
AYR59_RS02365 491808..493238 - 1431 WP_054646752.1 NADP-dependent phosphogluconate dehydrogenase -
AYR59_RS02370 493348..494832 - 1485 WP_056997740.1 glucose-6-phosphate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-90)

Antitoxin

Protein of unknown function DUF6290

(1-72)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10930.73 Da        Isoelectric Point: 10.7564

>T61885 WP_054646754.1 NZ_CP014907:490797-491072 [Fructilactobacillus lindneri]
MERKHYKLRISSVSKKQLKKMDKHQAKLILQWLLNNVDGIDNPRRIGKGLTSNQSWKWRYRIGNYRAICEIEDQYLVVTA
INIGHRRTMYD

Download         Length: 276 bp

>T61885 NZ_CP014907:490797-491072 [Fructilactobacillus lindneri]
ATGGAAAGAAAGCATTATAAATTAAGAATTTCATCAGTTTCAAAAAAGCAGTTAAAAAAGATGGATAAACATCAAGCTAA
ATTAATTTTACAATGGCTGCTTAACAATGTTGATGGTATTGATAATCCACGTCGAATTGGCAAGGGATTGACTAGTAATC
AAAGTTGGAAATGGCGTTATCGGATTGGAAATTATCGAGCAATTTGCGAAATTGAAGATCAATATTTAGTTGTTACGGCA
ATCAATATTGGTCATCGCCGAACGATGTATGATTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 9107.33 Da        Isoelectric Point: 4.4179

>AT61885 WP_054646755.1 NZ_CP014907:490504-490737 [Fructilactobacillus lindneri]
MATITVRVSTEEKEWLQEMADFYGISLSELVKNYSIEQIEDEYDRQTAVTAHKLWLKDNKKSEPIEKVMRDLDLLDK

Download         Length: 234 bp

>AT61885 NZ_CP014907:490504-490737 [Fructilactobacillus lindneri]
ATGGCTACAATTACTGTGAGAGTATCCACTGAAGAAAAGGAATGGTTACAAGAAATGGCTGATTTTTATGGAATTTCATT
ATCAGAACTAGTTAAAAATTATTCAATTGAACAAATTGAAGATGAATATGATCGACAAACGGCAGTGACGGCTCACAAAT
TATGGTTGAAAGATAATAAAAAATCAGAACCAATTGAAAAAGTCATGAGGGATTTAGATTTGTTAGACAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R2JSQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A0R2JVQ8

References