Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/YoeB-RelB
Location 1149952..1150471 Replicon chromosome
Accession NZ_CP014890
Organism Loigolactobacillus backii strain TMW 1.1992

Toxin (Protein)


Gene name Txe Uniprot ID A0A1Q8FGW1
Locus tag AYR55_RS05260 Protein ID WP_068224043.1
Coordinates 1150214..1150471 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID A0A1Q8FGV7
Locus tag AYR55_RS05255 Protein ID WP_068224048.1
Coordinates 1149952..1150221 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYR55_RS05240 1145742..1146920 + 1179 WP_068224053.1 cyclopropane-fatty-acyl-phospholipid synthase family protein -
AYR55_RS05245 1147391..1147942 - 552 WP_068224051.1 sugar O-acetyltransferase -
AYR55_RS05250 1148195..1149502 - 1308 WP_068224049.1 AAA family ATPase -
AYR55_RS05255 1149952..1150221 + 270 WP_068224048.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AYR55_RS05260 1150214..1150471 + 258 WP_068224043.1 Txe/YoeB family addiction module toxin Toxin
AYR55_RS05265 1150579..1151517 - 939 WP_068224042.1 restriction endonuclease -
AYR55_RS05270 1151578..1152246 - 669 WP_068376967.1 hypothetical protein -
AYR55_RS05275 1152481..1153941 - 1461 WP_068224036.1 FAD-dependent oxidoreductase -
AYR55_RS05280 1154290..1155183 + 894 WP_082918495.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-70)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10230.64 Da        Isoelectric Point: 9.4927

>T61880 WP_068224043.1 NZ_CP014890:1150214-1150471 [Loigolactobacillus backii]
MVKAWSDGAWNDYLYWHSKNDRAIIKKINRLIKDIERTPYEGLGKPEPLKYELAGKWSRRISDEHRLIYQVANETIYIYS
AKDHY

Download         Length: 258 bp

>T61880 NZ_CP014890:1150214-1150471 [Loigolactobacillus backii]
ATGGTTAAAGCCTGGTCAGATGGCGCTTGGAATGATTACCTGTACTGGCACAGTAAAAATGATAGGGCCATCATTAAAAA
AATAAATCGCTTGATTAAGGATATTGAAAGAACACCCTACGAAGGATTGGGGAAACCTGAACCATTGAAATACGAACTGG
CCGGTAAATGGTCGCGGCGAATAAGTGATGAGCACCGCTTAATTTACCAAGTAGCCAACGAAACAATTTACATTTACTCC
GCTAAGGATCACTATTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10288.49 Da        Isoelectric Point: 4.7833

>AT61880 WP_068224048.1 NZ_CP014890:1149952-1150221 [Loigolactobacillus backii]
MDAVAYSNFRQKLKDYMRQVNDDSDALIVTSKNSEENIVVMGKRDYDAMQETMRVLSNNYLMDKIKQGDQQFAKGTFKTH
DLITDENNG

Download         Length: 270 bp

>AT61880 NZ_CP014890:1149952-1150221 [Loigolactobacillus backii]
ATGGATGCTGTAGCATACTCTAATTTTCGACAAAAATTAAAAGATTATATGCGCCAGGTTAACGATGATTCGGATGCTTT
AATTGTAACTAGTAAAAATTCGGAAGAAAATATTGTTGTCATGGGTAAACGCGATTACGATGCAATGCAAGAAACGATGC
GCGTTTTATCAAATAATTATCTGATGGATAAAATTAAACAAGGCGATCAGCAATTCGCTAAAGGTACTTTTAAAACCCAT
GACCTAATTACGGATGAAAATAATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q8FGW1

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8FGV7

References