Detailed information of TA system TA061878

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Txe-Axe/YoeB-RelB
• Location: 828292..828811
• Replicon: chromosome
• Accession: NZ_CP014881
• Organism: Loigolactobacillus backii strain TMW 1.1991

Toxin (Protein)

• Gene name: Txe
• Uniprot ID: -
• Locus tag: AYR54_RS03775
• Protein ID: WP_068478696.1
• Coordinates: 828292..828549 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: Axe
• Uniprot ID: A0A1Q8FGV7
• Locus tag: AYR54_RS03780
• Protein ID: WP_068224048.1
• Coordinates: 828542..828811 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AYR54_RS03755	823580..824473	-	894	WP_082918495.1	LysR family transcriptional regulator	-
AYR54_RS03760	824822..826282	+	1461	WP_068224036.1	FAD-dependent oxidoreductase	-
AYR54_RS03765	826517..827185	+	669	WP_068376967.1	hypothetical protein	-
AYR54_RS03770	827246..828184	+	939	WP_068224042.1	restriction endonuclease	-
AYR54_RS03775	828292..828549	-	258	WP_068478696.1	Txe/YoeB family addiction module toxin	Toxin
AYR54_RS03780	828542..828811	-	270	WP_068224048.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
AYR54_RS03785	829261..830568	+	1308	WP_068224049.1	AAA family ATPase	-
AYR54_RS03790	830821..831372	+	552	WP_068224051.1	sugar O-acetyltransferase	-
AYR54_RS03795	831843..833021	-	1179	WP_068224053.1	cyclopropane-fatty-acyl-phospholipid synthase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (2-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-70)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10204.61 Da
• Isoelectric Point: 9.5467

>T61878 WP_068478696.1 NZ_CP014881:c828549-828292 [Loigolactobacillus backii]
MVKAWSDGAWNDYLYWHSKNDRAIIKKINRLIKDIERTPHEGLGKPEPLKYELAGKWSRRISDEHRLIYQVANETIYIYS
AKDHY

Nucleotide

• Length: 258 bp

>T61878 NZ_CP014881:c828549-828292 [Loigolactobacillus backii]
ATGGTTAAAGCCTGGTCAGATGGCGCTTGGAATGATTACCTGTACTGGCACAGTAAAAATGATAGGGCCATCATTAAAAA
AATAAATCGCTTGATTAAGGATATTGAAAGAACACCCCACGAAGGATTGGGGAAACCTGAACCATTGAAATACGAACTGG
CCGGTAAATGGTCGCGGCGAATAAGTGATGAGCACCGCTTAATTTACCAAGTAGCCAACGAAACAATTTACATTTACTCC
GCTAAGGATCACTATTAG

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10288.49 Da
• Isoelectric Point: 4.7833

>AT61878 WP_068224048.1 NZ_CP014881:c828811-828542 [Loigolactobacillus backii]
MDAVAYSNFRQKLKDYMRQVNDDSDALIVTSKNSEENIVVMGKRDYDAMQETMRVLSNNYLMDKIKQGDQQFAKGTFKTH
DLITDENNG

Nucleotide

• Length: 270 bp

>AT61878 NZ_CP014881:c828811-828542 [Loigolactobacillus backii]
ATGGATGCTGTAGCATACTCTAATTTTCGACAAAAATTAAAAGATTATATGCGCCAGGTTAACGATGATTCGGATGCTTT
AATTGTAACTAGTAAAAATTCGGAAGAAAATATTGTTGTCATGGGTAAACGCGATTACGATGCAATGCAAGAAACGATGC
GCGTTTTATCAAATAATTATCTGATGGATAAAATTAAACAAGGCGATCAGCAATTCGCTAAAGGTACTTTTAAAACCCAT
GACCTAATTACGGATGAAAATAATGGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A1Q8FGV7