Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 491033..491601 Replicon chromosome
Accession NZ_CP014872
Organism Fructilactobacillus lindneri strain TMW 1.1993

Toxin (Protein)


Gene name relE Uniprot ID A0A0R2JSQ8
Locus tag AYR60_RS02355 Protein ID WP_054646754.1
Coordinates 491326..491601 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0R2JVQ8
Locus tag AYR60_RS02350 Protein ID WP_054646755.1
Coordinates 491033..491266 (+) Length 78 a.a.

Genomic Context

AYR60_RS02330AYR60_RS02335AYR60_RS02350AYR60_RS02355AYR60_RS02360AYR60_RS02340AYR60_RS02345AYR60_RS02365AYR60_RS02370
Location: 486742..487200 (459 bp)
Type: Others
Protein ID: WP_054646758.1
Location: 487242..487631 (390 bp)
Type: Others
Protein ID: WP_054646757.1
Location: 491033..491266 (234 bp)
Type: Antitoxin
Protein ID: WP_054646755.1
Location: 491326..491601 (276 bp)
Type: Toxin
Protein ID: WP_054646754.1
Location: 491673..492269 (597 bp)
Type: Others
Protein ID: WP_054646753.1
Location: 487776..489152 (1377 bp)
Type: Others
Protein ID: WP_056997739.1
Location: 489308..490858 (1551 bp)
Type: Others
Protein ID: WP_065866150.1
Location: 492337..493767 (1431 bp)
Type: Others
Protein ID: WP_054646752.1
Location: 493877..495361 (1485 bp)
Type: Others
Protein ID: WP_065866151.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AYR60_RS02330486742..487200+459WP_054646758.1LysR family transcriptional regulator-
AYR60_RS02335487242..487631+390WP_054646757.1hypothetical protein-
AYR60_RS02340487776..489152-1377WP_056997739.1amino acid permease-
AYR60_RS02345489308..490858-1551WP_065866150.1multicopper oxidase domain-containing protein-
AYR60_RS02350491033..491266+234WP_054646755.1antitoxinAntitoxin
AYR60_RS02355491326..491601+276WP_054646754.1type II toxin-antitoxin system RelE/ParE family toxinToxin
AYR60_RS02360491673..492269+597WP_054646753.1DUF1054 family protein-
AYR60_RS02365492337..493767-1431WP_054646752.1NADP-dependent phosphogluconate dehydrogenase-
AYR60_RS02370493877..495361-1485WP_065866151.1glucose-6-phosphate dehydrogenase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-90)

Antitoxin

Protein of unknown function DUF6290

(1-72)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10930.73 Da        Isoelectric Point: 10.7564

>T61875 WP_054646754.1 NZ_CP014872:491326-491601 [Fructilactobacillus lindneri]
MERKHYKLRISSVSKKQLKKMDKHQAKLILQWLLNNVDGIDNPRRIGKGLTSNQSWKWRYRIGNYRAICEIEDQYLVVTA
INIGHRRTMYD

Download         Length: 276 bp

>T61875 NZ_CP014872:491326-491601 [Fructilactobacillus lindneri]
ATGGAAAGAAAGCATTATAAATTAAGAATTTCATCAGTTTCAAAAAAGCAGTTAAAAAAGATGGATAAACATCAAGCTAA
ATTAATTTTACAATGGCTGCTTAACAATGTTGATGGTATTGATAATCCACGTCGAATTGGCAAGGGATTGACTAGTAATC
AAAGTTGGAAATGGCGTTATCGGATTGGAAATTATCGAGCAATTTGCGAAATTGAAGATCAATATTTAGTTGTTACGGCA
ATCAATATTGGTCATCGCCGAACGATGTATGATTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 9107.33 Da        Isoelectric Point: 4.4179

>AT61875 WP_054646755.1 NZ_CP014872:491033-491266 [Fructilactobacillus lindneri]
MATITVRVSTEEKEWLQEMADFYGISLSELVKNYSIEQIEDEYDRQTAVTAHKLWLKDNKKSEPIEKVMRDLDLLDK

Download         Length: 234 bp

>AT61875 NZ_CP014872:491033-491266 [Fructilactobacillus lindneri]
ATGGCTACAATTACTGTGAGAGTATCCACTGAAGAAAAGGAATGGTTACAAGAAATGGCTGATTTTTATGGAATTTCATT
ATCAGAACTAGTTAAAAATTATTCAATTGAACAAATTGAAGATGAATATGATCGACAAACGGCAGTGACGGCTCACAAAT
TATGGTTGAAAGATAATAAAAAATCAGAACCAATTGAAAAAGTCATGAGGGATTTAGATTTGTTAGACAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0R2JSQ8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0R2JVQ8

References