Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 491033..491601 Replicon chromosome
Accession NZ_CP014872
Organism Fructilactobacillus lindneri strain TMW 1.1993

Toxin (Protein)


Gene name relE Uniprot ID A0A0R2JSQ8
Locus tag AYR60_RS02355 Protein ID WP_054646754.1
Coordinates 491326..491601 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0R2JVQ8
Locus tag AYR60_RS02350 Protein ID WP_054646755.1
Coordinates 491033..491266 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYR60_RS02330 486742..487200 + 459 WP_054646758.1 LysR family transcriptional regulator -
AYR60_RS02335 487242..487631 + 390 WP_054646757.1 hypothetical protein -
AYR60_RS02340 487776..489152 - 1377 WP_056997739.1 amino acid permease -
AYR60_RS02345 489308..490858 - 1551 WP_065866150.1 multicopper oxidase domain-containing protein -
AYR60_RS02350 491033..491266 + 234 WP_054646755.1 antitoxin Antitoxin
AYR60_RS02355 491326..491601 + 276 WP_054646754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AYR60_RS02360 491673..492269 + 597 WP_054646753.1 DUF1054 family protein -
AYR60_RS02365 492337..493767 - 1431 WP_054646752.1 NADP-dependent phosphogluconate dehydrogenase -
AYR60_RS02370 493877..495361 - 1485 WP_065866151.1 glucose-6-phosphate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-90)

Antitoxin

Protein of unknown function DUF6290

(1-72)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10930.73 Da        Isoelectric Point: 10.7564

>T61875 WP_054646754.1 NZ_CP014872:491326-491601 [Fructilactobacillus lindneri]
MERKHYKLRISSVSKKQLKKMDKHQAKLILQWLLNNVDGIDNPRRIGKGLTSNQSWKWRYRIGNYRAICEIEDQYLVVTA
INIGHRRTMYD

Download         Length: 276 bp

>T61875 NZ_CP014872:491326-491601 [Fructilactobacillus lindneri]
ATGGAAAGAAAGCATTATAAATTAAGAATTTCATCAGTTTCAAAAAAGCAGTTAAAAAAGATGGATAAACATCAAGCTAA
ATTAATTTTACAATGGCTGCTTAACAATGTTGATGGTATTGATAATCCACGTCGAATTGGCAAGGGATTGACTAGTAATC
AAAGTTGGAAATGGCGTTATCGGATTGGAAATTATCGAGCAATTTGCGAAATTGAAGATCAATATTTAGTTGTTACGGCA
ATCAATATTGGTCATCGCCGAACGATGTATGATTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 9107.33 Da        Isoelectric Point: 4.4179

>AT61875 WP_054646755.1 NZ_CP014872:491033-491266 [Fructilactobacillus lindneri]
MATITVRVSTEEKEWLQEMADFYGISLSELVKNYSIEQIEDEYDRQTAVTAHKLWLKDNKKSEPIEKVMRDLDLLDK

Download         Length: 234 bp

>AT61875 NZ_CP014872:491033-491266 [Fructilactobacillus lindneri]
ATGGCTACAATTACTGTGAGAGTATCCACTGAAGAAAAGGAATGGTTACAAGAAATGGCTGATTTTTATGGAATTTCATT
ATCAGAACTAGTTAAAAATTATTCAATTGAACAAATTGAAGATGAATATGATCGACAAACGGCAGTGACGGCTCACAAAT
TATGGTTGAAAGATAATAAAAAATCAGAACCAATTGAAAAAGTCATGAGGGATTTAGATTTGTTAGACAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R2JSQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A0R2JVQ8

References