61872

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4858974..4859590 Replicon chromosome
Accession NZ_CP014870
Organism Pseudomonas silesiensis strain A3

Toxin (Protein)


Gene name hicA Uniprot ID A0A191YXU3
Locus tag PMA3_RS21400 Protein ID WP_064679057.1
Coordinates 4859378..4859590 (-) Length 71 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A191YXF6
Locus tag PMA3_RS21395 Protein ID WP_064679056.1
Coordinates 4858974..4859378 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMA3_RS21375 4854495..4855409 + 915 WP_064679053.1 urea transporter -
PMA3_RS21380 4855431..4856255 + 825 WP_064679054.1 ion transporter -
PMA3_RS21385 4856475..4857473 + 999 WP_064680773.1 sulfate ABC transporter substrate-binding protein -
PMA3_RS21390 4857703..4858908 + 1206 WP_064679055.1 MFS transporter -
PMA3_RS21395 4858974..4859378 - 405 WP_064679056.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PMA3_RS21400 4859378..4859590 - 213 WP_064679057.1 type II toxin-antitoxin system HicA family toxin Toxin
PMA3_RS32960 4859847..4860089 + 243 Protein_4275 PIN domain-containing protein -
PMA3_RS21410 4860092..4860841 - 750 WP_064679058.1 phosphonate metabolism protein PhnP -
PMA3_RS21415 4860832..4861401 - 570 WP_064679059.1 phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN -
PMA3_RS21420 4861401..4862546 - 1146 WP_064679060.1 alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase -
PMA3_RS21425 4862536..4863255 - 720 WP_064679061.1 phosphonate C-P lyase system protein PhnL -
PMA3_RS21430 4863285..4864094 - 810 WP_064679062.1 phosphonate C-P lyase system protein PhnK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 7871.13 Da        Isoelectric Point: 10.2317

>T61872 WP_064679057.1 NZ_CP014870:c4859590-4859378 [Pseudomonas silesiensis]
VQSRLLIKELEEAGWTLDRVTGSHHLFTHRYNPYTIPVPHPKKDLPIGTVKSIRRRAGLICPRAGCTGDP

Download         Length: 213 bp

>T61872 NZ_CP014870:c4859590-4859378 [Pseudomonas silesiensis]
GTGCAGAGCAGGTTATTGATCAAGGAGCTGGAAGAGGCGGGCTGGACGCTGGATCGGGTCACTGGCAGTCATCACCTCTT
CACTCACCGCTACAACCCATACACGATTCCCGTCCCTCATCCGAAAAAGGATTTACCGATCGGGACGGTCAAAAGCATCA
GGAGGCGCGCCGGGCTGATCTGCCCGCGAGCCGGTTGCACAGGAGATCCATAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14803.78 Da        Isoelectric Point: 4.3929

>AT61872 WP_064679056.1 NZ_CP014870:c4859378-4858974 [Pseudomonas silesiensis]
MQYPICIEWGDENTAIGIQIPDIPGAVTAGDTFEDAYNAAIEIAHIMLQEMAADGESIPMPSSAAAHRNNPEFADMGWGM
LELDIAPYMGKTEKVNVTLPGYVIQRIDHYVREHNVKSRSSFLADAAMEKLVRH

Download         Length: 405 bp

>AT61872 NZ_CP014870:c4859378-4858974 [Pseudomonas silesiensis]
ATGCAATATCCAATCTGTATCGAGTGGGGCGACGAGAACACCGCCATCGGTATTCAGATCCCCGATATTCCAGGTGCGGT
AACCGCCGGGGATACGTTTGAAGATGCCTACAACGCTGCAATCGAAATAGCCCACATCATGCTGCAGGAAATGGCGGCCG
ACGGGGAATCGATTCCCATGCCGAGTTCGGCGGCTGCACATCGCAACAATCCCGAGTTTGCCGACATGGGCTGGGGCATG
CTGGAGCTGGACATCGCGCCCTATATGGGCAAGACCGAGAAGGTCAATGTGACGCTGCCGGGCTATGTGATCCAGCGTAT
CGACCACTATGTGCGCGAGCACAATGTCAAAAGCCGCTCTTCCTTTCTGGCGGATGCGGCGATGGAGAAGCTGGTTCGGC
ATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A191YXU3

Antitoxin

Source ID Structure
AlphaFold DB A0A191YXF6

References