Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 4251683..4253400 Replicon chromosome
Accession NZ_CP014870
Organism Pseudomonas silesiensis strain A3

Toxin (Protein)


Gene name doc Uniprot ID A0A191YWE9
Locus tag PMA3_RS18850 Protein ID WP_064678599.1
Coordinates 4251683..4252567 (+) Length 295 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag PMA3_RS18855 Protein ID WP_082930373.1
Coordinates 4252564..4253400 (+) Length 279 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMA3_RS18825 4247664..4248515 + 852 WP_082930372.1 ABC transporter ATP-binding protein -
PMA3_RS18830 4248555..4249556 + 1002 WP_064678596.1 ABC transporter substrate-binding protein -
PMA3_RS18835 4249585..4250361 + 777 WP_064678597.1 ABC transporter permease -
PMA3_RS18840 4250358..4251125 + 768 WP_191637822.1 SDR family oxidoreductase -
PMA3_RS18845 4251139..4251678 + 540 WP_064678598.1 cupin domain-containing protein -
PMA3_RS18850 4251683..4252567 + 885 WP_064678599.1 alpha/beta hydrolase Toxin
PMA3_RS18855 4252564..4253400 + 837 WP_082930373.1 IclR family transcriptional regulator Antitoxin
PMA3_RS18860 4253402..4254199 + 798 WP_064678600.1 SDR family oxidoreductase -
PMA3_RS18865 4254192..4255874 + 1683 WP_064678601.1 thiamine pyrophosphate-binding protein -
PMA3_RS18870 4255885..4256688 + 804 WP_064678602.1 aspartate dehydrogenase -
PMA3_RS18875 4256699..4258195 + 1497 WP_064678603.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(47-278)

Antitoxin

Transcription regulator IclR, N-terminal

(19-68)


Sequences

Toxin        


Download         Length: 295 a.a.        Molecular weight: 31400.09 Da        Isoelectric Point: 7.0262

>T61871 WP_064678599.1 NZ_CP014870:4251683-4252567 [Pseudomonas silesiensis]
MLHAIDTLVPPLTADLQAQLALHFPQRTLELAGARQAVRECGAGPAIVLLHGIGSGSASWLQVAQELGQSARVIAWDAPG
YGDSTPLRALAPDASDYAERLLQMLDALDIQRCVLVGHSLGAITATAFASGVHQQRISRLVLISPAQGYGHPSRALQRQE
VRNKRLRALDQLGIQGMAEQRSAYMLSPHASPKAHAWVQWNMARLNPEGYRQAIELLCGDDLLRHAPLSMPCEVHCGEAD
RITAPESCLTLAKALCGTFNLIADAGHASPIEQPCVVAGRLACAIKESLTGASL

Download         Length: 885 bp

>T61871 NZ_CP014870:4251683-4252567 [Pseudomonas silesiensis]
ATGTTGCACGCCATCGACACACTCGTCCCGCCGCTCACGGCCGACCTCCAGGCCCAGCTGGCCCTGCACTTTCCCCAGCG
CACGCTGGAGCTCGCAGGTGCCCGCCAGGCCGTACGCGAATGCGGGGCCGGGCCGGCCATCGTGTTGCTGCACGGAATCG
GCTCGGGCTCGGCGTCGTGGCTGCAGGTGGCGCAAGAGCTTGGCCAGAGCGCCCGGGTGATCGCCTGGGACGCGCCCGGC
TATGGCGATTCCACGCCGTTGAGAGCGTTGGCCCCGGACGCGTCGGACTACGCAGAACGGCTGCTGCAGATGCTCGACGC
CCTGGACATCCAGCGCTGTGTGCTGGTGGGTCACTCACTGGGGGCGATCACCGCCACGGCGTTCGCCAGCGGCGTGCACC
AGCAGCGCATCAGCCGGCTGGTCTTGATCAGCCCGGCCCAGGGCTACGGCCATCCATCGCGCGCCCTGCAGCGCCAGGAA
GTGCGCAACAAACGCCTGCGTGCCCTGGATCAACTGGGCATCCAGGGCATGGCCGAACAACGCAGTGCCTACATGCTCTC
GCCCCACGCCAGCCCCAAGGCGCACGCCTGGGTGCAGTGGAACATGGCCCGGCTCAATCCCGAGGGTTATCGCCAGGCCA
TTGAGCTGCTGTGCGGCGATGACCTGCTGCGCCACGCCCCGCTGTCGATGCCGTGCGAAGTGCATTGCGGCGAAGCCGAC
CGCATCACCGCGCCCGAAAGCTGCCTGACCCTGGCCAAGGCCCTGTGCGGCACGTTCAACCTTATCGCCGATGCCGGGCA
TGCCAGCCCCATCGAACAACCTTGTGTGGTGGCGGGCCGTCTGGCCTGTGCCATCAAAGAATCCCTGACTGGTGCATCGC
TATGA

Antitoxin


Download         Length: 279 a.a.        Molecular weight: 30902.46 Da        Isoelectric Point: 6.3483

>AT61871 WP_082930373.1 NZ_CP014870:4252564-4253400 [Pseudomonas silesiensis]
MNDSDLLKDAQDKYIVPGLERGLLLLCEFSRRNRTLTAPELARRLALPRSTIFRLLTTLETMGFVTRSGNEYRLGMSVLR
LGFEYLASLELTELGQPLLARLCDRLNYPSNLVVRDGRSIVYVAKVSPPSVFSSAVNVGTRLPAHATVLGRILLEDLSLA
ELRELYPEDHLEQFSPCTPKTVMELFDMVQADRQRGFVSGEGFFESAISTVAAPVRDQSGQIVAALGVTIPTTQIAHVNF
NELLLQVRRSADELSRLLDYNSAAGHDGQHRVTALMRD

Download         Length: 837 bp

>AT61871 NZ_CP014870:4252564-4253400 [Pseudomonas silesiensis]
ATGAACGATTCAGATCTGCTGAAGGACGCTCAGGACAAATACATCGTGCCGGGCCTGGAGCGCGGCCTCCTGCTGCTGTG
CGAGTTCAGCCGGCGCAACCGCACGCTGACCGCGCCGGAACTGGCCCGGCGCCTGGCGCTGCCGCGCTCGACGATTTTCC
GCTTGCTGACGACCCTGGAAACCATGGGCTTCGTCACCCGCAGCGGCAATGAATATCGCCTGGGCATGTCGGTGCTGCGC
CTGGGCTTCGAATACCTGGCCTCGCTGGAACTGACCGAACTCGGCCAGCCGCTCTTGGCCCGCCTGTGCGATCGCCTCAA
CTACCCGAGTAACCTGGTGGTGCGCGACGGCCGTTCGATCGTCTACGTGGCCAAGGTCTCGCCGCCGTCGGTGTTCTCCA
GCGCGGTGAATGTCGGCACCCGCCTGCCCGCCCACGCCACGGTCCTGGGGCGCATCCTGCTCGAAGACCTGTCGCTGGCC
GAGCTGCGCGAGCTGTACCCGGAAGATCACCTGGAGCAGTTCTCGCCCTGCACGCCGAAGACCGTGATGGAACTGTTCGA
CATGGTCCAGGCCGACCGCCAGCGCGGGTTCGTCAGCGGTGAAGGCTTCTTCGAGTCAGCCATTTCCACCGTCGCCGCAC
CGGTGCGCGATCAATCCGGGCAGATCGTCGCGGCCCTGGGCGTGACCATTCCGACCACGCAGATCGCCCACGTCAACTTC
AACGAATTGCTCCTGCAGGTGCGTCGCAGCGCCGACGAGCTGTCGCGGTTGCTCGACTACAACAGCGCTGCCGGCCACGA
CGGCCAGCACCGCGTGACCGCCCTGATGAGGGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A191YWE9

Antitoxin

Source ID Structure

References