Detailed information of TA system TA061870

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prcAT/RES-TIGR02293
• Location: 4037200..4038092
• Replicon: chromosome
• Accession: NZ_CP014870
• Organism: Pseudomonas silesiensis strain A3

Toxin (Protein)

• Gene name: PrcT
• Uniprot ID: A0A191YW23
• Locus tag: PMA3_RS17890
• Protein ID: WP_064678425.1
• Coordinates: 4037646..4038092 (+)
• Length: 149 a.a.

Antitoxin (Protein)

• Gene name: PrcA
• Uniprot ID: A0A191YVK5
• Locus tag: PMA3_RS17885
• Protein ID: WP_064678424.1
• Coordinates: 4037200..4037649 (+)
• Length: 150 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PMA3_RS17860	4032285..4033337	+	1053	WP_064678419.1	ABC transporter substrate-binding protein	-
PMA3_RS17865	4033353..4034420	+	1068	WP_064678420.1	ABC transporter ATP-binding protein	-
PMA3_RS17870	4034417..4035259	+	843	WP_064678421.1	ABC transporter permease	-
PMA3_RS17875	4035256..4036044	+	789	WP_064678422.1	ABC transporter permease	-
PMA3_RS17880	4036081..4037094	+	1014	WP_064678423.1	proline racemase family protein	-
PMA3_RS17885	4037200..4037649	+	450	WP_064678424.1	DUF2384 domain-containing protein	Antitoxin
PMA3_RS17890	4037646..4038092	+	447	WP_064678425.1	RES family NAD+ phosphorylase	Toxin
PMA3_RS17895	4038216..4038569	-	354	WP_064678426.1	RidA family protein	-
PMA3_RS17900	4038579..4039757	-	1179	WP_064678427.1	FAD-binding oxidoreductase	-
PMA3_RS17905	4039750..4041126	-	1377	WP_064678428.1	NAD(P)/FAD-dependent oxidoreductase	-
PMA3_RS17910	4041123..4041476	-	354	WP_064678429.1	(2Fe-2S)-binding protein	-
PMA3_RS17915	4041466..4042608	-	1143	WP_064678430.1	FAD-binding oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-140)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (97-146)

Sequences

Toxin

Protein

• Length: 149 a.a.
• Molecular weight: 16309.07 Da
• Isoelectric Point: 5.9761

>T61870 WP_064678425.1 NZ_CP014870:4037646-4038092 [Pseudomonas silesiensis]
MIFWRISAFADLTGRGGTLAGGRWHTAGRPVVYLAGTPAGAMLEILVHLEIDQEDLPETLQLLKVEVPDDVSLSPAPVLK
PDWEFELNHTKGIGDLFLKGCPALLLAVPSAIMPHSLNYLFNPMHLDSVKAVITAEPFRLDNRLFKKL

Nucleotide

• Length: 447 bp

>T61870 NZ_CP014870:4037646-4038092 [Pseudomonas silesiensis]
TTGATCTTTTGGCGGATAAGCGCTTTTGCAGATCTGACGGGACGTGGCGGCACCCTCGCGGGGGGACGCTGGCATACGGC
GGGGCGACCGGTCGTCTATCTTGCCGGGACACCTGCCGGCGCAATGCTCGAAATCCTGGTACACCTCGAGATCGATCAGG
AAGACCTTCCAGAGACGCTCCAGTTGCTCAAGGTCGAGGTGCCTGACGATGTCAGCCTCTCCCCTGCCCCGGTACTCAAG
CCAGATTGGGAATTCGAGCTGAACCACACCAAGGGCATAGGCGATTTATTCCTCAAAGGATGCCCTGCCCTGCTGTTGGC
GGTACCGAGCGCTATCATGCCGCATTCGCTGAACTACCTGTTCAACCCTATGCACCTGGATTCGGTCAAGGCCGTCATTA
CCGCCGAGCCGTTCAGGCTCGACAACCGACTGTTCAAGAAATTGTAG

Antitoxin

Protein

• Length: 150 a.a.
• Molecular weight: 16697.21 Da
• Isoelectric Point: 6.7244

>AT61870 WP_064678424.1 NZ_CP014870:4037200-4037649 [Pseudomonas silesiensis]
MLAEIMREPAYGAYRARLHALLQIPTNASDLEIHDIIQIGFAAGRLVSLCEQGELTPLERDQIIPLKTLKTRVAKDQNLT
VDESDRLFRAAHITAMADAVFGNDEKAKRWLSKPKERFSGRSPMAMLSTVQGTRQVEETLIQLAEGYAF

Nucleotide

• Length: 450 bp

>AT61870 NZ_CP014870:4037200-4037649 [Pseudomonas silesiensis]
ATGCTAGCTGAAATCATGCGTGAACCCGCCTACGGTGCCTACCGCGCTCGGCTGCACGCCTTGCTGCAAATTCCCACCAA
TGCGTCTGACCTGGAAATCCACGACATCATCCAGATCGGCTTTGCAGCTGGCCGTCTTGTGTCGCTTTGCGAACAGGGTG
AATTGACGCCGCTTGAGCGCGACCAGATCATCCCTCTGAAAACCCTGAAGACCCGGGTCGCTAAAGACCAGAACCTCACG
GTCGACGAGAGTGATCGGCTGTTCCGCGCCGCCCACATCACCGCCATGGCAGACGCTGTATTTGGCAACGATGAAAAAGC
CAAACGCTGGCTGTCGAAACCCAAGGAGCGATTTTCGGGCCGCAGCCCAATGGCAATGCTGTCGACGGTACAGGGAACAC
GCCAGGTCGAGGAAACGCTGATCCAGTTGGCCGAGGGCTACGCCTTTTGA

Structures

Toxin

• AlphaFold DB: A0A191YW23

Antitoxin

• AlphaFold DB: A0A191YVK5