Detailed information of TA system TA061868

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 91311..91827
• Replicon: chromosome
• Accession: NZ_CP014870
• Organism: Pseudomonas silesiensis strain A3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: PMA3_RS30375
• Protein ID: WP_082930237.1
• Coordinates: 91546..91827 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A191Z232
• Locus tag: PMA3_RS00425
• Protein ID: WP_064680588.1
• Coordinates: 91311..91556 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PMA3_RS00400	86703..87569	+	867	WP_064675316.1	ABC transporter permease	-
PMA3_RS30370	87594..88637	-	1044	WP_082930236.1	RHS repeat-associated core domain-containing protein	-
PMA3_RS00405	88850..89608	-	759	WP_064675317.1	slipin family protein	-
PMA3_RS00410	89611..90141	-	531	WP_064675318.1	serine protease	-
PMA3_RS00415	90405..90866	+	462	WP_064675319.1	YbaK/EbsC family protein	-
PMA3_RS00420	90986..91231	+	246	WP_064675320.1	DUF2789 domain-containing protein	-
PMA3_RS00425	91311..91556	+	246	WP_064680588.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
PMA3_RS30375	91546..91827	+	282	WP_082930237.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PMA3_RS00430	91967..92395	+	429	WP_064680589.1	winged helix DNA-binding protein	-
PMA3_RS00435	92392..94464	+	2073	WP_064675321.1	FUSC family protein	-
PMA3_RS00440	94461..94670	+	210	WP_064675322.1	DUF1656 domain-containing protein	-
PMA3_RS00445	94667..95554	+	888	WP_064675323.1	HlyD family secretion protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-70)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10918.73 Da
• Isoelectric Point: 10.3023

>T61868 WP_082930237.1 NZ_CP014870:91546-91827 [Pseudomonas silesiensis]
MTYKLEFLPSAHKEWNKLGHTVRDQFKKKLTQRLELPRVPSDALHGMPECYKIKLKSSGYRLVYEVIDERVVVSVVAVGK
RERSDVYENAKKR

Nucleotide

• Length: 282 bp

>T61868 NZ_CP014870:91546-91827 [Pseudomonas silesiensis]
ATGACTTATAAGCTCGAATTCCTGCCATCGGCTCATAAAGAGTGGAACAAATTGGGGCACACAGTACGTGATCAATTCAA
AAAGAAACTGACGCAGAGATTGGAACTACCTCGTGTCCCCTCAGACGCGCTGCATGGCATGCCTGAATGCTACAAAATAA
AGCTGAAGTCTTCTGGATACCGACTTGTCTACGAGGTTATTGATGAGCGTGTAGTCGTTTCTGTCGTGGCGGTTGGTAAG
CGCGAACGTAGCGATGTTTATGAAAATGCCAAGAAACGTTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8926.36 Da
• Isoelectric Point: 4.7164

>AT61868 WP_064680588.1 NZ_CP014870:91311-91556 [Pseudomonas silesiensis]
MQNVLADMAVSVTELKKNPSAVLSGALGGPVAVLNHNRVMGYMVPADVFERMVERLDDLELAEIIRSRRHETPIPVTLDD
L

Nucleotide

• Length: 246 bp

>AT61868 NZ_CP014870:91311-91556 [Pseudomonas silesiensis]
ATGCAAAATGTATTGGCCGACATGGCCGTCAGTGTGACGGAGCTGAAGAAGAACCCCTCTGCAGTCCTGAGCGGTGCCCT
AGGTGGACCCGTGGCGGTACTGAATCACAATCGAGTCATGGGATACATGGTACCCGCGGATGTTTTCGAGCGCATGGTGG
AGCGACTTGATGACCTTGAACTGGCAGAAATCATTCGTTCGCGTCGTCATGAAACGCCGATTCCGGTAACACTGGATGAC
TTATAA

Structures

Antitoxin

• AlphaFold DB: A0A191Z232