61863

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-higA/HigB-HigA
Location 2401652..2402346 Replicon chromosome
Accession NZ_CP014867
Organism Pseudomonas chlororaphis strain 189 isolate 189

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag A3218_RS10340 Protein ID WP_062823884.1
Coordinates 2402050..2402346 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A3218_RS10335 Protein ID WP_062823883.1
Coordinates 2401652..2402053 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A3218_RS10325 2396785..2400135 + 3351 WP_009041854.1 mechanosensitive channel MscK -
A3218_RS10330 2400184..2401647 + 1464 WP_062823882.1 YdiU family protein -
A3218_RS10335 2401652..2402053 - 402 WP_062823883.1 transcriptional regulator Antitoxin
A3218_RS10340 2402050..2402346 - 297 WP_062823884.1 type II toxin-antitoxin system HigB family toxin Toxin
A3218_RS10345 2402571..2403005 + 435 WP_062823885.1 thioredoxin TrxC -
A3218_RS10350 2403044..2403814 - 771 WP_009041850.1 ParA family protein -
A3218_RS10355 2404149..2404880 + 732 WP_062823886.1 beta-ketoacyl synthase chain length factor -
A3218_RS10360 2404856..2405671 + 816 WP_062823887.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
A3218_RS10365 2405646..2405906 + 261 WP_007926834.1 acyl carrier protein -
A3218_RS10370 2405916..2406170 + 255 WP_007926835.1 acyl carrier protein -
A3218_RS10375 2406167..2406712 + 546 WP_062823888.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-90)

Antitoxin

Antitoxin HigA

(15-133)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11625.59 Da        Isoelectric Point: 10.7938

>T61863 WP_062823884.1 NZ_CP014867:c2402346-2402050 [Pseudomonas chlororaphis]
MRVITAKRIWDAKEKWPQSAKALDDWYRALKRNRLADFAAMKAMFPAVDKVGPLHVFDIGGNKIRLIALVRYTTQKLYIR
HVLDHREYDRGKWKEDRG

Download         Length: 297 bp

>T61863 NZ_CP014867:c2402346-2402050 [Pseudomonas chlororaphis]
ATGCGTGTAATCACGGCTAAACGAATTTGGGATGCCAAGGAAAAATGGCCACAGTCGGCCAAGGCGTTGGATGATTGGTA
TCGCGCGCTTAAACGCAATCGGCTTGCGGATTTTGCCGCGATGAAGGCGATGTTTCCGGCGGTGGACAAGGTCGGACCGC
TGCATGTGTTCGATATCGGTGGCAACAAGATACGGCTGATTGCATTGGTCCGTTATACGACGCAAAAGCTCTATATCCGC
CATGTGTTGGACCACCGTGAATATGACCGGGGTAAGTGGAAGGAGGATCGAGGATGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 15183.39 Da        Isoelectric Point: 4.5530

>AT61863 WP_062823883.1 NZ_CP014867:c2402053-2401652 [Pseudomonas chlororaphis]
MSALIEQVAEHWQFVAPLLRKPKTEADYDRLVQALDELLDLTGEDEAHPLNSLVDIIGDWIEAYDLEHRPMPVASGIDVL
RYMMREHGLTQSDLPGVGAQSVVSEILSGKRQLNLRQIRWLAERFKVSMETFI

Download         Length: 402 bp

>AT61863 NZ_CP014867:c2402053-2401652 [Pseudomonas chlororaphis]
ATGAGTGCATTGATCGAGCAAGTGGCCGAACACTGGCAGTTCGTTGCGCCGTTGCTGCGCAAGCCGAAAACCGAGGCGGA
CTACGACAGACTGGTTCAGGCCCTTGACGAGTTGTTGGACCTGACAGGGGAAGATGAGGCCCATCCTCTCAACAGCCTGG
TGGACATCATCGGGGACTGGATCGAAGCCTACGATCTTGAACATCGCCCGATGCCTGTTGCCAGCGGAATAGATGTGTTG
CGCTACATGATGCGCGAACACGGTCTGACCCAGAGCGACCTGCCCGGTGTCGGCGCGCAGTCGGTAGTCTCGGAGATCCT
GAGCGGCAAGCGTCAGCTCAACCTGCGTCAGATCCGCTGGCTGGCCGAACGTTTCAAGGTCTCGATGGAAACCTTTATCT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References