Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 4583891..4584438 Replicon chromosome
Accession NZ_CP014866
Organism Pseudomonas aeruginosa strain PA_154197

Toxin (Protein)


Gene name relE Uniprot ID A0A6A9K6G2
Locus tag AXW93_RS21775 Protein ID WP_023102603.1
Coordinates 4584163..4584438 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A6A9LA76
Locus tag AXW93_RS21770 Protein ID WP_023102602.1
Coordinates 4583891..4584163 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXW93_RS21750 4580557..4581588 + 1032 WP_080911747.1 hypothetical protein -
AXW93_RS21755 4581599..4582264 + 666 WP_049859794.1 DUF3218 family protein -
AXW93_RS30860 4582686..4583021 + 336 WP_185832033.1 hypothetical protein -
AXW93_RS21765 4583078..4583638 - 561 WP_023102601.1 recombinase family protein -
AXW93_RS21770 4583891..4584163 + 273 WP_023102602.1 ribbon-helix-helix domain-containing protein Antitoxin
AXW93_RS21775 4584163..4584438 + 276 WP_023102603.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AXW93_RS21785 4585537..4586397 - 861 WP_196797922.1 cytolethal distending toxin subunit B family protein -
AXW93_RS21790 4586414..4586950 - 537 WP_079279916.1 hypothetical protein -
AXW93_RS21795 4587272..4588000 - 729 WP_049859666.1 SDR family oxidoreductase -
AXW93_RS21800 4588644..4589282 + 639 WP_080911926.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4527231..4622184 94953


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(10-47)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10689.27 Da        Isoelectric Point: 9.9307

>T61857 WP_023102603.1 NZ_CP014866:4584163-4584438 [Pseudomonas aeruginosa]
MELKWTNKGLSDLTRLYEFLAAVNRSAAARTVQQLTSAPTKLLANPRIGERLEEFDPRDVRRILVGHYEMRYEIAGSTIY
LLRLWHTREDR

Download         Length: 276 bp

>T61857 NZ_CP014866:4584163-4584438 [Pseudomonas aeruginosa]
ATGGAGTTGAAGTGGACGAACAAGGGGCTGTCCGATCTGACTCGACTATATGAGTTCCTGGCGGCTGTGAACCGTTCCGC
TGCGGCACGTACCGTGCAACAGCTAACGAGCGCACCGACTAAGCTGCTGGCCAACCCGCGCATCGGTGAGCGCCTGGAAG
AGTTCGATCCGCGTGACGTGCGGCGGATTCTGGTCGGGCATTACGAGATGCGCTACGAAATTGCCGGCTCTACCATCTAT
CTGCTGCGTCTGTGGCACACCCGTGAAGATCGCTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10087.34 Da        Isoelectric Point: 4.6413

>AT61857 WP_023102602.1 NZ_CP014866:4583891-4584163 [Pseudomonas aeruginosa]
MPANAKTRSVTAHVPIELAERVDDIAERLERSKNWIVKQALTAWLDQEDERSRLTREALVDVDAGCVIDHQAVQAWADSL
STDTPLPVPR

Download         Length: 273 bp

>AT61857 NZ_CP014866:4583891-4584163 [Pseudomonas aeruginosa]
ATGCCCGCTAACGCCAAAACCAGATCTGTCACCGCCCATGTCCCCATTGAGCTGGCCGAACGTGTCGATGACATCGCAGA
GCGCCTGGAGCGCTCCAAGAACTGGATCGTCAAGCAGGCTCTTACAGCCTGGCTCGACCAGGAAGACGAGCGTAGCCGCC
TGACCCGCGAGGCTCTGGTGGATGTGGATGCCGGCTGCGTGATTGACCATCAGGCAGTCCAGGCCTGGGCCGATAGCCTT
AGTACCGACACTCCGCTGCCGGTGCCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6A9K6G2

Antitoxin

Source ID Structure
AlphaFold DB A0A6A9LA76

References