Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /Xre(antitoxin) |
| Location | 2098296..2099443 | Replicon | chromosome |
| Accession | NZ_CP014864 | ||
| Organism | Microbulbifer thermotolerans strain DAU221 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A143HMB5 |
| Locus tag | A3224_RS08810 | Protein ID | WP_067153520.1 |
| Coordinates | 2098296..2099081 (-) | Length | 262 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A143HN27 |
| Locus tag | A3224_RS08815 | Protein ID | WP_067153522.1 |
| Coordinates | 2099078..2099443 (-) | Length | 122 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A3224_RS08785 | 2093573..2094559 | - | 987 | WP_067153514.1 | glycosyltransferase family 2 protein | - |
| A3224_RS08790 | 2094572..2095216 | - | 645 | WP_067153516.1 | ABC transporter ATP-binding protein | - |
| A3224_RS08795 | 2095213..2096082 | - | 870 | WP_082817458.1 | ABC transporter permease | - |
| A3224_RS08800 | 2096251..2097120 | - | 870 | WP_067157736.1 | NAD(+) kinase | - |
| A3224_RS08805 | 2097292..2098353 | - | 1062 | WP_156481457.1 | pyridoxal-phosphate dependent enzyme | - |
| A3224_RS08810 | 2098296..2099081 | - | 786 | WP_067153520.1 | RES family NAD+ phosphorylase | Toxin |
| A3224_RS08815 | 2099078..2099443 | - | 366 | WP_067153522.1 | MbcA/ParS/Xre antitoxin family protein | Antitoxin |
| A3224_RS08830 | 2099886..2102009 | - | 2124 | WP_197462965.1 | hypothetical protein | - |
| A3224_RS08835 | 2102404..2103027 | - | 624 | WP_067153526.1 | adenylyl-sulfate kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 262 a.a. Molecular weight: 29125.20 Da Isoelectric Point: 6.4910
>T61852 WP_067153520.1 NZ_CP014864:c2099081-2098296 [Microbulbifer thermotolerans]
VSGDLLQRIHSNCQRLLGRLYRIVESQEEVATRSLVDNLQKQQVLEELLEQSKPPRLPGSENLHYLLATPFRYPPLPWGS
RFGGTAESGIFYGSKTIPTVLAEAAYYRLLFFHDMDPVPLHPITSYHLIFSAKYCADPGIRLQDPAWASDWSKVTHPEDY
QFCQKLGSQLRQAGIMGLETPSARALQAALAQLPPSNSEGINVALFEPGALLKRPPMQEADVTADTSEKEVVFLVKFGNR
TETCSFALESFQVNGRLPRPA
VSGDLLQRIHSNCQRLLGRLYRIVESQEEVATRSLVDNLQKQQVLEELLEQSKPPRLPGSENLHYLLATPFRYPPLPWGS
RFGGTAESGIFYGSKTIPTVLAEAAYYRLLFFHDMDPVPLHPITSYHLIFSAKYCADPGIRLQDPAWASDWSKVTHPEDY
QFCQKLGSQLRQAGIMGLETPSARALQAALAQLPPSNSEGINVALFEPGALLKRPPMQEADVTADTSEKEVVFLVKFGNR
TETCSFALESFQVNGRLPRPA
Download Length: 786 bp
>T61852 NZ_CP014864:c2099081-2098296 [Microbulbifer thermotolerans]
GTGAGCGGCGATTTATTGCAGCGCATTCACTCCAATTGTCAACGTCTGCTTGGCCGCTTGTATCGGATCGTCGAATCTCA
GGAGGAGGTCGCTACCCGTAGCCTGGTCGACAATCTGCAGAAACAGCAAGTGCTGGAAGAACTGCTGGAACAGAGCAAGC
CACCGCGTTTGCCCGGCAGTGAAAATCTGCATTATCTCTTGGCAACCCCTTTCCGCTATCCGCCTTTACCTTGGGGTTCC
CGCTTCGGCGGTACAGCGGAATCCGGCATATTCTATGGCAGCAAAACAATTCCCACGGTGCTTGCCGAAGCTGCCTACTA
CCGATTACTGTTTTTCCATGACATGGACCCGGTGCCCCTGCACCCCATTACCAGTTACCACCTTATCTTTTCCGCCAAGT
ACTGTGCTGATCCCGGTATCCGGCTACAAGACCCGGCCTGGGCAAGTGACTGGTCGAAAGTGACGCACCCGGAGGACTAC
CAATTTTGCCAAAAGCTGGGCAGTCAGCTACGCCAAGCCGGCATCATGGGTCTTGAGACACCTTCAGCACGTGCTTTGCA
AGCGGCGTTGGCACAATTGCCCCCCAGCAACTCAGAAGGCATTAATGTCGCCCTGTTCGAACCCGGGGCGTTGCTCAAGC
GTCCGCCCATGCAGGAAGCAGATGTCACAGCGGATACCAGCGAAAAGGAAGTGGTTTTTCTGGTGAAGTTCGGAAACCGA
ACGGAGACGTGCAGTTTTGCCCTGGAAAGCTTTCAGGTCAATGGACGGCTACCGAGGCCGGCATGA
GTGAGCGGCGATTTATTGCAGCGCATTCACTCCAATTGTCAACGTCTGCTTGGCCGCTTGTATCGGATCGTCGAATCTCA
GGAGGAGGTCGCTACCCGTAGCCTGGTCGACAATCTGCAGAAACAGCAAGTGCTGGAAGAACTGCTGGAACAGAGCAAGC
CACCGCGTTTGCCCGGCAGTGAAAATCTGCATTATCTCTTGGCAACCCCTTTCCGCTATCCGCCTTTACCTTGGGGTTCC
CGCTTCGGCGGTACAGCGGAATCCGGCATATTCTATGGCAGCAAAACAATTCCCACGGTGCTTGCCGAAGCTGCCTACTA
CCGATTACTGTTTTTCCATGACATGGACCCGGTGCCCCTGCACCCCATTACCAGTTACCACCTTATCTTTTCCGCCAAGT
ACTGTGCTGATCCCGGTATCCGGCTACAAGACCCGGCCTGGGCAAGTGACTGGTCGAAAGTGACGCACCCGGAGGACTAC
CAATTTTGCCAAAAGCTGGGCAGTCAGCTACGCCAAGCCGGCATCATGGGTCTTGAGACACCTTCAGCACGTGCTTTGCA
AGCGGCGTTGGCACAATTGCCCCCCAGCAACTCAGAAGGCATTAATGTCGCCCTGTTCGAACCCGGGGCGTTGCTCAAGC
GTCCGCCCATGCAGGAAGCAGATGTCACAGCGGATACCAGCGAAAAGGAAGTGGTTTTTCTGGTGAAGTTCGGAAACCGA
ACGGAGACGTGCAGTTTTGCCCTGGAAAGCTTTCAGGTCAATGGACGGCTACCGAGGCCGGCATGA
Antitoxin
Download Length: 122 a.a. Molecular weight: 13194.34 Da Isoelectric Point: 9.8736
>AT61852 WP_067153522.1 NZ_CP014864:c2099443-2099078 [Microbulbifer thermotolerans]
MTSIPNYQPHPSGDAVLLEALLNTADHLGLKKKELGEIIHLDDRTLRRRSGLDPESAPGQLALLLVRAYRAAFVLMGGAE
GARYWFSTPNRALGGVPKTLACRIDGLVRIVSYLDAMRGKV
MTSIPNYQPHPSGDAVLLEALLNTADHLGLKKKELGEIIHLDDRTLRRRSGLDPESAPGQLALLLVRAYRAAFVLMGGAE
GARYWFSTPNRALGGVPKTLACRIDGLVRIVSYLDAMRGKV
Download Length: 366 bp
>AT61852 NZ_CP014864:c2099443-2099078 [Microbulbifer thermotolerans]
ATGACTTCAATTCCCAATTATCAGCCTCACCCCAGTGGTGACGCGGTACTTCTCGAAGCCCTGTTGAACACCGCTGACCA
CCTTGGGCTGAAAAAGAAAGAGCTCGGCGAAATCATCCATCTGGACGATCGTACCCTGAGGCGCAGAAGCGGGCTTGACC
CGGAAAGTGCCCCCGGCCAACTGGCTCTCCTGCTAGTGCGCGCATACCGAGCGGCCTTTGTGCTGATGGGGGGAGCGGAA
GGCGCTCGCTATTGGTTCTCGACACCCAACCGCGCTCTGGGAGGGGTGCCCAAGACACTGGCGTGCCGCATTGATGGGCT
AGTCCGAATTGTCTCCTACCTGGATGCCATGCGGGGTAAGGTGTGA
ATGACTTCAATTCCCAATTATCAGCCTCACCCCAGTGGTGACGCGGTACTTCTCGAAGCCCTGTTGAACACCGCTGACCA
CCTTGGGCTGAAAAAGAAAGAGCTCGGCGAAATCATCCATCTGGACGATCGTACCCTGAGGCGCAGAAGCGGGCTTGACC
CGGAAAGTGCCCCCGGCCAACTGGCTCTCCTGCTAGTGCGCGCATACCGAGCGGCCTTTGTGCTGATGGGGGGAGCGGAA
GGCGCTCGCTATTGGTTCTCGACACCCAACCGCGCTCTGGGAGGGGTGCCCAAGACACTGGCGTGCCGCATTGATGGGCT
AGTCCGAATTGTCTCCTACCTGGATGCCATGCGGGGTAAGGTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A143HMB5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A143HN27 |