Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1038027..1038630 Replicon chromosome
Accession NZ_CP014862
Organism Thermococcus profundus strain DT 5432

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag A3L09_RS05645 Protein ID WP_088859001.1
Coordinates 1038027..1038419 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag A3L09_RS05650 Protein ID WP_088858023.1
Coordinates 1038406..1038630 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A3L09_RS05630 (A3L09_05600) 1034673..1036895 + 2223 WP_088858020.1 DHH family phosphoesterase -
A3L09_RS05635 (A3L09_05605) 1036972..1037226 + 255 WP_088858021.1 hypothetical protein -
A3L09_RS05640 (A3L09_05610) 1037268..1037969 + 702 WP_088858022.1 HAD family hydrolase -
A3L09_RS05645 (A3L09_05615) 1038027..1038419 - 393 WP_088859001.1 type II toxin-antitoxin system VapC family toxin Toxin
A3L09_RS05650 (A3L09_05620) 1038406..1038630 - 225 WP_088858023.1 hypothetical protein Antitoxin
A3L09_RS05655 (A3L09_05625) 1038789..1041116 - 2328 WP_088858024.1 DNA polymerase -
A3L09_RS05660 (A3L09_05630) 1041113..1041400 - 288 WP_088858025.1 hypothetical protein -
A3L09_RS05665 (A3L09_05635) 1041480..1042835 + 1356 WP_088858026.1 RsmB/NOP family class I SAM-dependent RNA methyltransferase -
A3L09_RS05670 (A3L09_05640) 1042988..1043473 + 486 WP_157727205.1 PIN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(3-122)

Antitoxin

Putative antitoxin VapB3-like

(1-74)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14527.84 Da        Isoelectric Point: 4.9851

>T61850 WP_088859001.1 NZ_CP014862:c1038419-1038027 [Thermococcus profundus]
VIVADASVLIKVLLKEPGWEEIGLGTDTATLDYALVEGMNAIWKAVRRNRITEENAKSLVTVLRLLGEGMLLFRAENFFE
RGLEIALKEGITIYDALYIALAEALNAELHTADEKQYYAARNYVKAKLAR

Download         Length: 393 bp

>T61850 NZ_CP014862:c1038419-1038027 [Thermococcus profundus]
GTGATAGTCGCTGATGCATCCGTTCTCATCAAAGTCCTCCTCAAAGAACCCGGCTGGGAGGAAATAGGTCTTGGGACGGA
CACGGCAACCTTGGACTACGCGCTCGTCGAAGGAATGAACGCCATCTGGAAGGCCGTCAGAAGGAACAGAATAACGGAGG
AGAACGCCAAAAGCCTTGTAACGGTTCTGAGGCTCCTAGGGGAGGGGATGCTCCTGTTCCGGGCTGAGAACTTCTTCGAG
CGGGGCCTTGAGATAGCCCTTAAGGAGGGCATCACGATTTACGATGCCCTCTACATAGCCCTGGCTGAGGCCCTCAATGC
AGAACTCCACACTGCTGATGAGAAACAGTACTATGCAGCTCGGAATTACGTAAAGGCGAAGCTGGCGAGGTAG

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8885.33 Da        Isoelectric Point: 10.4766

>AT61850 WP_088858023.1 NZ_CP014862:c1038630-1038406 [Thermococcus profundus]
MAVITVRVPDELKLKMRELNINWSKEIREFIRKRIDEEERRKKIDEAMEILKRTPVSVEKGFGAKSVRDDRDSR

Download         Length: 225 bp

>AT61850 NZ_CP014862:c1038630-1038406 [Thermococcus profundus]
ATGGCGGTCATAACCGTTAGGGTTCCCGACGAGTTGAAGCTCAAGATGCGGGAGCTTAACATAAACTGGAGTAAGGAGAT
AAGGGAGTTCATACGAAAAAGAATAGACGAAGAGGAGCGGAGGAAAAAGATAGATGAGGCGATGGAAATACTGAAGCGCA
CTCCCGTCTCGGTTGAAAAGGGCTTTGGGGCAAAATCCGTGAGGGATGACCGTGATAGTCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References