Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Xre-MNT/HTH_26(antitoxin)
Location 549278..550386 Replicon chromosome
Accession NZ_CP014861
Organism Erysipelothrix rhusiopathiae strain GXBY-1

Toxin (Protein)


Gene name MNTss Uniprot ID A0A2I4SCC6
Locus tag A2I91_RS02670 Protein ID WP_062810426.1
Coordinates 549517..550386 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name Xress Uniprot ID B9DSK1
Locus tag A2I91_RS02665 Protein ID WP_002303393.1
Coordinates 549278..549502 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A2I91_RS02645 544279..544842 + 564 Protein_509 recombinase zinc beta ribbon domain-containing protein -
A2I91_RS02650 545285..546769 + 1485 WP_002294513.1 ABC-F type ribosomal protection protein Lsa(E) -
A2I91_RS02655 546823..547626 + 804 WP_002294514.1 lincosamide nucleotidyltransferase Lnu(B) -
A2I91_RS02660 548314..549135 + 822 Protein_512 recombinase zinc beta ribbon domain-containing protein -
A2I91_RS02665 549278..549502 + 225 WP_002303393.1 helix-turn-helix transcriptional regulator Antitoxin
A2I91_RS02670 549517..550386 + 870 WP_062810426.1 nucleotidyltransferase domain-containing protein Toxin
A2I91_RS02675 550367..551101 + 735 WP_000662263.1 class I SAM-dependent methyltransferase -
A2I91_RS02680 551134..552042 + 909 WP_001255864.1 aminoglycoside nucleotidyltransferase ANT(6)-Ia -
A2I91_RS02685 552039..552581 + 543 WP_000627290.1 streptothricin N-acetyltransferase Sat4 -
A2I91_RS02690 552674..553468 + 795 WP_001096887.1 aminoglycoside O-phosphotransferase APH(3')-IIIa -
A2I91_RS02695 553744..554316 + 573 WP_001079938.1 HTH domain-containing protein -
A2I91_RS02700 554289..554696 + 408 WP_072387101.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polymerase, nucleotidyl transferase domain

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-57)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 32793.31 Da        Isoelectric Point: 4.6575

>T61849 WP_062810426.1 NZ_CP014861:549517-550386 [Erysipelothrix rhusiopathiae]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARSTHTENSDIDIGIYYNSDSFDLTAINQIATELDDENRNNLVVPPGAWGDW
VNGGGWLVINGCHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGAEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYNEVNEIVSEINNFLNEESSDERKQI

Download         Length: 870 bp

>T61849 NZ_CP014861:549517-550386 [Erysipelothrix rhusiopathiae]
ATGGTAGGTAATGTTATTCAAATAGTAACAGAGAAATTATCATCTTTGCCTTTTATAGAAGGCATTGTATTAGGGGGCTC
ACGTGCAAGAAGCACCCATACAGAAAATTCTGATATAGATATCGGAATCTATTACAATTCAGACTCATTTGACCTGACAG
CGATTAATCAAATTGCTACAGAGTTGGATGATGAGAATAGAAACAACCTTGTTGTACCTCCCGGAGCGTGGGGTGATTGG
GTTAATGGCGGTGGATGGTTAGTTATAAACGGGTGTCATGTTGACTTGATATTACGTGATATAAAACGGGTGGAACAAAT
AATCAAAGATACGGAGCAAGGAATTGTTACTGCCAATTATCAGACCGGGCATCCCCATGGTTATATAAGTGCTATGTATC
GTGGAGAATTAGCGATTAGTAAAATACTATATGCTAAGAACGAAAGCTTATGCGAATTAAAAAAGCAGGCAGAAATTTAC
CCTACTGCTCTAAAGAAAAGCTTGATGAACTTTTTTATATTTGAAGCTGAATTCTCTTTAATGTTTGTAAAAGCAAATGC
GGGGGCAGAGGATAAATATTATATTGCAGGCCATGTTTTTCGTATTATTTCATGCTTAAATCAAGTACTATTTGCATGTA
ATAATGCTTATTGCATTAACGAAAAGAAAGCTATAAAACTGCTTGAAACTTTTGAATATAAACCTGAAAAATATGCCGAA
AGAGTTAATCATATTTTTGAAGTACTCGGTCTTTCTCTTTTTGAATGCTACGACATGACCGAGAAACTTTATAATGAAGT
GAATGAAATTGTATCGGAGATAAATAACTTTTTAAACGAGGAGAGTTCAGATGAAAGAAAACAAATATGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8351.65 Da        Isoelectric Point: 4.5357

>AT61849 WP_002303393.1 NZ_CP014861:549278-549502 [Erysipelothrix rhusiopathiae]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGDEIKISNE

Download         Length: 225 bp

>AT61849 NZ_CP014861:549278-549502 [Erysipelothrix rhusiopathiae]
ATGACTACGGCAGAAATGATTAAAGAACTGTGTGAGCAAATGAATATAAGTGTTTCCGAACTTGCTAGACGTATTGGCCA
GACTCCACAGAATTTCAATAAAAAATTACAACGAGAAACAGTAACCTTGGATGAGTTGAAGGCTATTGCTGATGTGCTAG
GTGTCAAGTTTGTGCAGGCATTTATTTTACCAGATGGAGATGAAATAAAAATATCTAACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I4SCC6

Antitoxin

Source ID Structure
AlphaFold DB A0A1M5SHM7

References