Detailed information of TA system TA061844

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-AbrB
• Location: 373112..373737
• Replicon: chromosome
• Accession: NZ_CP014855
• Organism: Thermococcus gorgonarius strain W-12

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: A3K92_RS02140
• Protein ID: WP_088884703.1
• Coordinates: 373112..373522 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: A3K92_RS02145
• Protein ID: WP_088884704.1
• Coordinates: 373507..373737 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A3K92_RS02110 (A3K92_02110)	368478..368996	-	519	WP_088884697.1	RNA-binding protein	-
A3K92_RS02115 (A3K92_02115)	368996..369631	-	636	WP_088884698.1	orotidine-5'-phosphate decarboxylase	-
A3K92_RS02120 (A3K92_02120)	369636..370238	-	603	WP_088884699.1	DUF4443 domain-containing protein	-
A3K92_RS02125 (A3K92_02125)	370417..371148	+	732	WP_088884700.1	DUF72 domain-containing protein	-
A3K92_RS02130 (A3K92_02130)	371150..371977	-	828	WP_088884701.1	translation initiation factor IF-2B subunit alpha	-
A3K92_RS02135 (A3K92_02135)	372104..373111	+	1008	WP_088884702.1	phosphorylating glyceraldehyde-3-phosphate dehydrogenase	-
A3K92_RS02140 (A3K92_02140)	373112..373522	-	411	WP_088884703.1	PIN domain-containing protein	Toxin
A3K92_RS02145 (A3K92_02145)	373507..373737	-	231	WP_088884704.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
A3K92_RS02150 (A3K92_02150)	373796..374080	-	285	WP_088884705.1	DUF167 domain-containing protein	-
A3K92_RS02155 (A3K92_02155)	374139..374747	+	609	WP_088884706.1	tRNA (pseudouridine(54)-N(1))-methyltransferase TrmY	-
A3K92_RS02160 (A3K92_02160)	374744..375235	-	492	WP_088884707.1	DUF402 domain-containing protein	-
A3K92_RS02165 (A3K92_02165)	375244..375981	-	738	WP_088884708.1	sulfite exporter TauE/SafE family protein	-
A3K92_RS02170 (A3K92_02170)	376070..376276	+	207	WP_157722409.1	DUF86 domain-containing protein	-
A3K92_RS02175 (A3K92_02175)	376273..377985	-	1713	WP_088884710.1	glycine--tRNA ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-125)

Antitoxin

• SpoVT-AbrB domain (5-45)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15817.20 Da
• Isoelectric Point: 6.2463

>T61844 WP_088884703.1 NZ_CP014855:c373522-373112 [Thermococcus gorgonarius]
MHGVIDTNVLIYDTFEDTEFHSEAENMLESLDRWYVPTIVMQEYVWFFKNNGFSAKDALESLKGYMDDPRFRGLSESPKT
IENALNLLVREKISLSRFNDVVVLLHALEKGTLVTFDRKLRSLAKRKGIKVLPEKF

Nucleotide

• Length: 411 bp

>T61844 NZ_CP014855:c373522-373112 [Thermococcus gorgonarius]
ATGCATGGGGTCATAGACACGAACGTTCTCATCTATGACACCTTTGAGGACACAGAGTTCCACAGTGAAGCAGAGAACAT
GCTTGAGTCCCTGGATAGGTGGTATGTTCCGACAATAGTTATGCAAGAGTACGTGTGGTTCTTCAAAAACAACGGTTTTT
CGGCCAAAGATGCGCTTGAGTCTCTTAAGGGATACATGGATGATCCCAGGTTCAGGGGGCTGAGTGAAAGTCCCAAAACC
ATCGAGAATGCCCTAAACCTTCTGGTTAGAGAGAAAATCTCACTATCAAGGTTCAACGATGTTGTGGTTCTGCTTCATGC
TCTGGAGAAGGGAACACTAGTCACATTCGATAGAAAGCTCAGAAGCCTGGCAAAAAGAAAGGGAATAAAGGTTCTTCCGG
AAAAGTTTTAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8667.25 Da
• Isoelectric Point: 10.0576

>AT61844 WP_088884704.1 NZ_CP014855:c373737-373507 [Thermococcus gorgonarius]
MGITKVTRNYQITIPAEIRKALGIKEGEILEVSLEGDKIVIQRLKKQRKRLKLGRNITPEEIEKSIEEGMKECMGS

Nucleotide

• Length: 231 bp

>AT61844 NZ_CP014855:c373737-373507 [Thermococcus gorgonarius]
ATGGGCATTACAAAAGTAACGAGAAACTATCAAATAACTATCCCGGCGGAGATTAGAAAGGCCCTTGGGATAAAAGAAGG
GGAAATTCTTGAGGTTAGCCTCGAAGGAGACAAGATAGTGATTCAAAGACTCAAGAAACAGAGAAAACGCCTTAAGCTGG
GCAGGAACATCACTCCAGAGGAAATAGAGAAGTCCATTGAGGAGGGCATGAAAGAATGCATGGGGTCATAG