Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 3502061..3502638 Replicon chromosome
Accession NZ_CP014839
Organism Pandoraea thiooxydans strain ATSB16

Toxin (Protein)


Gene name vapC Uniprot ID A0A0G3EQ11
Locus tag PATSB16_RS16005 Protein ID WP_047215065.1
Coordinates 3502273..3502638 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0G3EUZ8
Locus tag PATSB16_RS16000 Protein ID WP_047215064.1
Coordinates 3502061..3502279 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PATSB16_RS15975 3497199..3498539 + 1341 WP_047215061.1 DUF1446 domain-containing protein -
PATSB16_RS15980 3498736..3499794 + 1059 WP_047216322.1 IS110 family transposase -
PATSB16_RS15985 3500100..3500417 + 318 WP_047215062.1 hypothetical protein -
PATSB16_RS15990 3500458..3501294 + 837 WP_047215063.1 aldo/keto reductase -
PATSB16_RS20920 3501393..3502080 + 688 Protein_3156 tyrosine-type recombinase/integrase -
PATSB16_RS16000 3502061..3502279 + 219 WP_047215064.1 ribbon-helix-helix protein, CopG family Antitoxin
PATSB16_RS16005 3502273..3502638 + 366 WP_047215065.1 type II toxin-antitoxin system VapC family toxin Toxin
PATSB16_RS21025 3503089..3503430 + 342 WP_047215066.1 hypothetical protein -
PATSB16_RS16010 3503445..3503681 + 237 Protein_3160 transposase -
PATSB16_RS16015 3503839..3505206 - 1368 WP_047216333.1 group II intron reverse transcriptase/maturase -
PATSB16_RS16025 3505688..3506767 - 1080 WP_156884875.1 porin -
PATSB16_RS16030 3506779..3507483 - 705 WP_047216663.1 sulfite exporter TauE/SafE family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3498718..3499794 1076


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-106)

Antitoxin

Ribbon-helix-helix protein, CopG

(4-41)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13490.62 Da        Isoelectric Point: 9.4365

>T61833 WP_047215065.1 NZ_CP014839:3502273-3502638 [Pandoraea thiooxydans]
MVKALFDTNVLIDYLGGISAAKKELGRYEYRAISTITWMEVLVGASTEEEKAIRSWLGSFDVIAVDSAIANRAVEIRKAR
RVRLPDAIIWATAQVHSLLLVSRNTKDFPADEPGVRVPYKV

Download         Length: 366 bp

>T61833 NZ_CP014839:3502273-3502638 [Pandoraea thiooxydans]
ATGGTAAAAGCGCTGTTTGACACGAATGTTCTCATCGACTACCTCGGCGGTATAAGCGCTGCAAAGAAGGAGTTGGGGCG
CTACGAATATCGTGCCATCAGCACGATTACGTGGATGGAAGTTCTTGTTGGTGCTTCCACCGAGGAAGAGAAAGCCATTC
GATCGTGGCTCGGCTCATTCGACGTTATTGCAGTTGACAGTGCCATAGCAAATCGCGCGGTTGAAATCCGCAAGGCAAGG
CGAGTTCGTCTTCCTGACGCCATCATTTGGGCAACGGCGCAAGTGCATTCGCTGTTGCTCGTTTCGCGCAATACAAAGGA
TTTTCCGGCTGACGAACCAGGCGTTCGAGTCCCATACAAAGTGTAG

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8317.51 Da        Isoelectric Point: 5.0807

>AT61833 WP_047215064.1 NZ_CP014839:3502061-3502279 [Pandoraea thiooxydans]
MSRILVDLPDSQIEELAVIVESEQRPRAAVIRDAIEAYIAQRKRTLGTDVFGLWKSKKVDGLTYQQELRSEW

Download         Length: 219 bp

>AT61833 NZ_CP014839:3502061-3502279 [Pandoraea thiooxydans]
ATGAGCCGAATCTTGGTTGATCTGCCTGATTCGCAGATCGAGGAGTTGGCGGTGATTGTGGAGTCGGAGCAACGCCCTCG
AGCGGCCGTTATCCGTGACGCCATCGAGGCATACATCGCGCAACGCAAACGCACGCTTGGTACCGATGTATTCGGATTGT
GGAAGAGCAAAAAGGTCGATGGCCTGACATACCAGCAGGAGCTTCGCTCGGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0G3EQ11

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3EUZ8

References