Detailed information of TA system TA061832

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 3336433..3337190
• Replicon: chromosome
• Accession: NZ_CP014839
• Organism: Pandoraea thiooxydans strain ATSB16

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: PATSB16_RS15270
• Protein ID: WP_206093709.1
• Coordinates: 3336433..3336915 (-)
• Length: 161 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: A0A0G3ESP8
• Locus tag: PATSB16_RS15275
• Protein ID: WP_047214941.1
• Coordinates: 3336918..3337190 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PATSB16_RS15260	3333557..3333919	+	363	WP_047214938.1	hypothetical protein	-
PATSB16_RS15265	3334061..3335836	-	1776	WP_047214939.1	SWIM zinc finger family protein	-
PATSB16_RS15270	3336433..3336915	-	483	WP_206093709.1	GNAT family N-acetyltransferase	Toxin
PATSB16_RS15275	3336918..3337190	-	273	WP_047214941.1	DUF1778 domain-containing protein	Antitoxin
PATSB16_RS15280	3337604..3338008	+	405	WP_047214942.1	DUF2946 domain-containing protein	-
PATSB16_RS15285	3338165..3338545	+	381	WP_047214943.1	copper resistance protein CopC	-
PATSB16_RS15290	3338547..3339434	+	888	WP_052892709.1	CopD family protein	-
PATSB16_RS15295	3339452..3340417	-	966	WP_047214944.1	NAD-dependent epimerase/dehydratase family protein	-
PATSB16_RS15300	3340430..3341632	-	1203	WP_083659395.1	glycine C-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (78-146)

Antitoxin

• Vibrio phage ICP1, Orf50 (3-86)

Sequences

Toxin

Protein

• Length: 161 a.a.
• Molecular weight: 17460.09 Da
• Isoelectric Point: 9.0966

>T61832 WP_206093709.1 NZ_CP014839:c3336915-3336433 [Pandoraea thiooxydans]
MQLSAPQSLAATHRLDGFNCGEPSLDDWLKRRALANHLNGASRTFVVTDPEQCVLGYYALAAGAVAHQETTSAVRRNMPD
PVPVMVLARLAVDARAQGIKLGAALLQDAVARVQTVAENAGVRALLVHALNDRAKQFYEHYGFRESPVHPMTLMFPMKAR

Nucleotide

• Length: 483 bp

>T61832 NZ_CP014839:c3336915-3336433 [Pandoraea thiooxydans]
ATGCAGCTTTCGGCCCCGCAGTCGCTCGCCGCGACGCATCGACTCGATGGGTTCAATTGCGGAGAGCCATCGCTGGACGA
TTGGTTAAAGCGTCGAGCATTGGCCAACCACCTGAACGGGGCAAGCCGCACCTTCGTCGTGACTGATCCTGAACAGTGCG
TACTTGGGTACTATGCTTTAGCAGCGGGGGCCGTCGCGCACCAGGAAACCACGAGCGCCGTCAGGCGCAATATGCCCGAT
CCGGTGCCGGTGATGGTGCTCGCCAGGCTCGCGGTAGATGCTCGCGCCCAAGGCATCAAACTCGGTGCGGCTTTGCTCCA
AGATGCTGTAGCTCGGGTGCAGACCGTTGCCGAGAATGCTGGTGTTCGGGCGCTGCTGGTCCATGCGTTGAACGATCGCG
CAAAGCAGTTCTATGAGCACTATGGTTTCCGGGAGTCGCCAGTTCACCCGATGACGTTGATGTTCCCCATGAAAGCACGG
TAG

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10072.53 Da
• Isoelectric Point: 5.8189

>AT61832 WP_047214941.1 NZ_CP014839:c3337190-3336918 [Pandoraea thiooxydans]
MRDASINLRALPEQRDLIDHAASLLGKNRSDFMLEAACERAKAIVLDQVFFNLDESRFRQFTALLDAPQDANPGLERLMA
IKAPWSASKA

Nucleotide

• Length: 273 bp

>AT61832 NZ_CP014839:c3337190-3336918 [Pandoraea thiooxydans]
ATGCGTGACGCCTCCATCAACTTACGTGCGCTGCCCGAGCAGCGCGACTTGATCGACCATGCCGCCAGTCTGCTGGGCAA
AAATCGCTCAGACTTCATGCTGGAAGCGGCGTGTGAACGCGCGAAGGCGATTGTGCTGGATCAGGTTTTTTTTAACCTGG
ACGAGAGCCGATTCCGGCAGTTCACTGCACTACTCGATGCGCCACAAGATGCCAATCCGGGCCTTGAACGGCTGATGGCG
ATTAAGGCACCGTGGAGCGCAAGTAAGGCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0G3ESP8