Detailed information of TA system TA061825

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 279319..279862
• Replicon: chromosome
• Accession: NZ_CP014805
• Organism: Elizabethkingia anophelis strain CSID_3015183678

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: A2T74_RS01210
• Protein ID: WP_061889061.1
• Coordinates: 279563..279862 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: A2T74_RS01205
• Protein ID: WP_061889060.1
• Coordinates: 279319..279570 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A2T74_RS01185	274796..275926	-	1131	WP_021346495.1	4-hydroxyphenylpyruvate dioxygenase	-
A2T74_RS01190	275989..277263	-	1275	WP_009085369.1	acetyl-CoA hydrolase/transferase family protein	-
A2T74_RS01195	277288..278442	-	1155	WP_021346497.1	homogentisate 1,2-dioxygenase	-
A2T74_RS01200	278717..279172	+	456	WP_061889059.1	nuclear transport factor 2 family protein	-
A2T74_RS01205	279319..279570	+	252	WP_061889060.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
A2T74_RS01210	279563..279862	+	300	WP_061889061.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A2T74_RS01215	280033..280686	+	654	WP_061889062.1	DKNYY domain-containing protein	-
A2T74_RS01220	280874..282211	-	1338	WP_061889063.1	peptidoglycan synthetase	-
A2T74_RS01225	282227..283045	-	819	WP_009085366.1	1-acyl-sn-glycerol-3-phosphate acyltransferase	-
A2T74_RS01230	283107..283733	-	627	WP_021346499.1	CoA pyrophosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	164808..418738	253930

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-92)

Antitoxin

• Antitoxin ParD (1-74)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11974.85 Da
• Isoelectric Point: 4.9476

>T61825 WP_061889061.1 NZ_CP014805:279563-279862 [Elizabethkingia anophelis]
MAKYFFTIKAVEDLTKIYEYTYEFWSENQADKYYEELIEFCRILAENPNIGKLYPEIGPGFYGFLVNKHIIFYRILKQNE
IEVERILGAEMDLKKRLKE

Nucleotide

• Length: 300 bp

>T61825 NZ_CP014805:279563-279862 [Elizabethkingia anophelis]
ATGGCTAAATATTTCTTTACAATTAAAGCGGTTGAAGATCTTACTAAAATCTATGAGTATACTTATGAATTCTGGTCGGA
AAATCAAGCTGATAAATATTATGAAGAATTAATTGAATTTTGCCGAATACTTGCTGAAAATCCAAATATTGGAAAATTAT
ACCCGGAAATAGGCCCAGGGTTTTATGGGTTTTTAGTGAACAAACATATAATATTTTACAGAATTCTAAAACAAAATGAA
ATAGAGGTTGAGAGAATTCTCGGTGCAGAAATGGACTTGAAAAAAAGATTAAAAGAATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9387.61 Da
• Isoelectric Point: 7.0134

>AT61825 WP_061889060.1 NZ_CP014805:279319-279570 [Elizabethkingia anophelis]
MGRNTSVSLGNYFEDFVDAKVTQGRYKNASEVIRAGLRLLEEEENKIQFLKNSVQEGVDSGIAKDFNPEKHLELLKVKMK
NNG

Nucleotide

• Length: 252 bp

>AT61825 NZ_CP014805:279319-279570 [Elizabethkingia anophelis]
ATGGGACGAAATACATCTGTTTCTTTGGGAAATTATTTTGAGGATTTTGTTGATGCAAAAGTTACTCAGGGAAGATATAA
AAACGCAAGTGAAGTAATTCGTGCCGGATTAAGACTTTTGGAAGAGGAAGAAAATAAAATTCAGTTTCTAAAAAATTCAG
TCCAGGAAGGAGTTGATAGTGGAATTGCAAAAGATTTTAATCCGGAAAAGCATCTTGAATTGTTAAAGGTCAAAATGAAG
AATAATGGCTAA