Detailed information of TA system TA061824

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 66932..67968
• Replicon: plasmid pTPRO5
• Accession: NZ_CP014801
• Organism: Salipiger profundus strain JLT2016

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: Ga0080559_RS24385
• Protein ID: WP_076625838.1
• Coordinates: 67393..67968 (+)
• Length: 192 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: -
• Locus tag: Ga0080559_RS24380
• Protein ID: WP_076625837.1
• Coordinates: 66932..67396 (+)
• Length: 155 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Ga0080559_RS24360	63176..64114	+	939	WP_076625833.1	TniB family NTP-binding protein	-
Ga0080559_RS24365	64111..65169	+	1059	WP_076625834.1	TniQ family protein	-
Ga0080559_RS24370	65315..66199	+	885	WP_076625835.1	DUF1403 family protein	-
Ga0080559_RS24375	66202..66798	+	597	WP_076625836.1	SMC-Scp complex subunit ScpB	-
Ga0080559_RS24380	66932..67396	+	465	WP_076625837.1	helix-turn-helix domain-containing protein	Antitoxin
Ga0080559_RS24385	67393..67968	+	576	WP_076625838.1	PIN domain-containing protein	Toxin
Ga0080559_RS24390	68088..69005	-	918	WP_076625839.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
Ga0080559_RS24395	68995..69825	-	831	WP_076625840.1	type IV toxin-antitoxin system AbiEi family antitoxin	-
Ga0080559_RS24400	70087..71154	-	1068	WP_076625841.1	patatin-like phospholipase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..102837	102837

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (11-115)

Antitoxin

• Helix-turn-helix domain, group 17 (85-133)

Sequences

Toxin

Protein

• Length: 192 a.a.
• Molecular weight: 20776.64 Da
• Isoelectric Point: 4.5456

>T61824 WP_076625838.1 NZ_CP014801:67393-67968 [Salipiger profundus]
MSRYADRFTALLDACVLGGALRRNMLLSLAEAGLFRPRWSSRILDETQKAITQITKGETDGSRQRAAIEAAFPEALVTGY
EIFEGKLALPDPGDNHVLAAAITTSASVIVTDNLADFPSAALDPHAIQAISADDFIADTIELDPSEAILALRRMRERFKN
PALDVAALIHKSEAQGLLQVATFMDEYQSFL

Nucleotide

• Length: 576 bp

>T61824 NZ_CP014801:67393-67968 [Salipiger profundus]
ATGAGCCGATACGCTGATCGGTTCACGGCTCTCCTCGATGCCTGCGTTCTTGGCGGCGCGCTTCGAAGAAACATGCTCCT
AAGCTTGGCCGAGGCCGGTTTGTTCCGGCCTCGGTGGAGCAGTCGCATTCTTGACGAGACTCAGAAGGCAATCACCCAGA
TTACCAAGGGCGAAACCGATGGTTCCCGGCAAAGGGCGGCAATCGAAGCGGCCTTCCCCGAAGCTCTGGTGACAGGCTAT
GAGATCTTCGAAGGCAAGCTCGCACTGCCCGATCCTGGCGACAACCACGTGCTGGCAGCAGCCATCACAACGTCTGCCTC
TGTCATCGTGACGGACAATCTCGCGGACTTTCCATCGGCGGCTTTGGACCCGCACGCCATCCAGGCGATTTCCGCCGACG
ACTTCATCGCCGATACAATCGAGCTGGATCCCTCAGAGGCCATTCTGGCCCTGCGCCGCATGCGGGAGCGTTTCAAAAAT
CCGGCGCTTGATGTTGCGGCTTTGATTCACAAGTCAGAAGCGCAGGGCCTATTGCAGGTTGCAACCTTCATGGACGAGTA
CCAGTCGTTCCTGTGA

Antitoxin

Protein

• Length: 155 a.a.
• Molecular weight: 16978.46 Da
• Isoelectric Point: 5.1019

>AT61824 WP_076625837.1 NZ_CP014801:66932-67396 [Salipiger profundus]
MNALRKEAFFDRLPDEVEIKNAEQLRTIVASQIKEGEPTKLSLALEGGEVRTVTLAPALTASLLEVLRLVSSGRGFRMIP
VESELTTQQAADLLNVSRPFLVKLLEEGEIPFAKTGRHRRVRADDLFAYKEKRDASRSGALSDLAAMDAEEGLV

Nucleotide

• Length: 465 bp

>AT61824 NZ_CP014801:66932-67396 [Salipiger profundus]
ATGAACGCCCTCAGAAAAGAGGCGTTCTTTGATCGTTTGCCCGACGAGGTCGAGATCAAGAACGCCGAACAACTCAGAAC
GATTGTCGCCTCCCAGATCAAGGAAGGCGAACCGACAAAGCTGTCGCTCGCCCTGGAAGGCGGCGAAGTTCGCACCGTGA
CGCTTGCGCCCGCCCTGACGGCTTCGCTGCTCGAGGTGCTGCGGCTTGTGTCGAGCGGTCGCGGGTTTCGGATGATCCCC
GTCGAGTCAGAGCTGACCACACAGCAGGCCGCGGACCTTCTCAATGTGTCCCGTCCGTTCTTGGTGAAGCTTCTCGAGGA
AGGCGAGATTCCGTTTGCGAAGACCGGCCGTCATCGCCGAGTTCGTGCCGACGATCTCTTTGCCTACAAGGAGAAGCGTG
ATGCGTCTCGCTCGGGTGCTTTGAGTGACCTTGCCGCAATGGATGCGGAAGAAGGTCTTGTATGA