Detailed information of TA system TA061823

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 8343..8886
• Replicon: plasmid pTPRO5
• Accession: NZ_CP014801
• Organism: Salipiger profundus strain JLT2016

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: Ga0080559_RS24065
• Protein ID: WP_076625788.1
• Coordinates: 8584..8886 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: Ga0080559_RS24060
• Protein ID: WP_076625866.1
• Coordinates: 8343..8594 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Ga0080559_RS24045	5131..7146	+	2016	WP_076625864.1	type IV secretory system conjugative DNA transfer family protein	-
Ga0080559_RS24050	7217..7780	-	564	WP_076625865.1	hypothetical protein	-
Ga0080559_RS24060	8343..8594	+	252	WP_076625866.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
Ga0080559_RS24065	8584..8886	+	303	WP_076625788.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
Ga0080559_RS24070	8976..9674	-	699	WP_076625789.1	RES family NAD+ phosphorylase	-
Ga0080559_RS24075	9668..10006	-	339	WP_076625867.1	MbcA/ParS/Xre antitoxin family protein	-
Ga0080559_RS24080	10425..12860	+	2436	WP_076625868.1	DEAD/DEAH box helicase	-
Ga0080559_RS24085	12885..13119	-	235	Protein_11	integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..102837	102837

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-92)

Antitoxin

• Antitoxin ParD (3-71)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11355.85 Da
• Isoelectric Point: 5.0813

>T61823 WP_076625788.1 NZ_CP014801:8584-8886 [Salipiger profundus]
MTREIRLSEAAGTDLIDIWAQTSRKWGPDQADRYLDDIEHSLNGLLDNPLIGTDCSDLLPGCRQLITGRHLAFYEVDGAA
IFVIRVLHQSMDVPRHLRDR

Nucleotide

• Length: 303 bp

>T61823 NZ_CP014801:8584-8886 [Salipiger profundus]
ATGACGCGTGAGATCCGGCTCAGCGAAGCCGCCGGAACCGATCTCATCGACATCTGGGCGCAGACATCCCGTAAATGGGG
ACCCGACCAGGCAGACAGATATCTCGACGACATCGAACATTCCCTGAACGGATTGCTCGACAATCCGCTGATCGGAACGG
ACTGTTCGGATCTCTTGCCGGGATGCAGGCAACTGATCACAGGCCGCCATCTTGCGTTCTACGAGGTCGATGGGGCCGCG
ATCTTCGTGATCCGGGTCCTGCATCAGTCCATGGATGTGCCGCGACATTTGAGGGATCGGTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9078.30 Da
• Isoelectric Point: 7.0135

>AT61823 WP_076625866.1 NZ_CP014801:8343-8594 [Salipiger profundus]
MASTSVTLGPHWDQFIALMLKEGRYGSTSELIRASLRLMEEQEGQRARLRVALMEGKDSGDAGPLDMATIKREARARSGA
NDA

Nucleotide

• Length: 252 bp

>AT61823 NZ_CP014801:8343-8594 [Salipiger profundus]
ATGGCAAGCACCAGCGTTACACTCGGCCCGCATTGGGACCAATTCATCGCCCTGATGCTGAAGGAGGGTCGGTACGGGTC
GACCAGCGAGTTGATCCGTGCCTCGCTGCGGCTCATGGAAGAGCAGGAGGGCCAACGCGCTCGGCTCCGGGTCGCCCTGA
TGGAGGGCAAGGATTCCGGCGATGCGGGACCGCTGGACATGGCCACGATCAAACGCGAGGCGCGGGCCAGGTCTGGTGCC
AATGACGCGTGA