Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 5016..5677 Replicon plasmid pTPRO4
Accession NZ_CP014800
Organism Salipiger profundus strain JLT2016

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag Ga0080559_RS23930 Protein ID WP_076625767.1
Coordinates 5016..5417 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag Ga0080559_RS23935 Protein ID WP_076625768.1
Coordinates 5414..5677 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Ga0080559_RS23910 245..580 + 336 WP_076625763.1 hypothetical protein -
Ga0080559_RS26450 654..848 - 195 WP_128549269.1 hypothetical protein -
Ga0080559_RS23915 1096..2346 + 1251 WP_076625764.1 transposase -
Ga0080559_RS23920 2936..4426 + 1491 WP_157895897.1 MobA/MobL family protein -
Ga0080559_RS23925 4696..5013 - 318 WP_076625766.1 hypothetical protein -
Ga0080559_RS23930 5016..5417 - 402 WP_076625767.1 type II toxin-antitoxin system VapC family toxin Toxin
Ga0080559_RS23935 5414..5677 - 264 WP_076625768.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
Ga0080559_RS26455 5862..6020 - 159 WP_157895898.1 hypothetical protein -
Ga0080559_RS23940 6264..7295 + 1032 WP_076625769.1 replication initiator protein A -
Ga0080559_RS23945 7490..7741 + 252 WP_076625770.1 helix-turn-helix domain-containing protein -
Ga0080559_RS23950 7909..8118 - 210 WP_076625771.1 hypothetical protein -
Ga0080559_RS23955 8108..8770 - 663 WP_076625772.1 AAA family ATPase -
Ga0080559_RS23960 8991..9239 - 249 WP_076625773.1 HigA family addiction module antidote protein -
Ga0080559_RS23965 9759..9941 + 183 WP_093412561.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..25119 25119


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(16-53)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14222.42 Da        Isoelectric Point: 7.1352

>T61822 WP_076625767.1 NZ_CP014800:c5417-5016 [Salipiger profundus]
MTRYMLDTNIISNLLRRPDGSAAKRIGEVGPDAICVSIITAAELRYGCAKKGSAKLLAHVEAILESVQVLALDVPADAEY
GGIRAELETASKPIGPNDLLIAAHARAIGAVLVTDNTGEFSRVRGLRVENWIR

Download         Length: 402 bp

>T61822 NZ_CP014800:c5417-5016 [Salipiger profundus]
TTGACCCGCTACATGCTCGACACCAATATCATCTCCAATCTGCTGCGACGTCCTGACGGCAGTGCGGCAAAGCGTATTGG
CGAGGTCGGGCCAGATGCGATCTGCGTGAGCATCATCACAGCCGCAGAGCTGCGGTATGGGTGCGCCAAGAAAGGGTCCG
CGAAACTCCTGGCGCATGTGGAAGCGATACTGGAAAGCGTGCAGGTTCTGGCGCTCGATGTGCCTGCTGACGCGGAGTAT
GGCGGCATTCGTGCCGAGCTTGAGACCGCTAGCAAGCCCATTGGGCCGAACGATCTGTTGATCGCAGCTCATGCCCGCGC
CATAGGCGCAGTCCTCGTGACTGACAACACCGGCGAGTTTTCCCGCGTTCGCGGCCTCCGGGTTGAAAACTGGATCAGGT
AG

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9893.28 Da        Isoelectric Point: 4.8552

>AT61822 WP_076625768.1 NZ_CP014800:c5677-5414 [Salipiger profundus]
MPHPHPDSAPREAKLFRNNKSQAVRIPADFEMPGDRVNIYREGNRLIIEPVRRKNLLEVLAGLDPLGPEDQFPDVDETLL
PAKEIDL

Download         Length: 264 bp

>AT61822 NZ_CP014800:c5677-5414 [Salipiger profundus]
ATGCCGCATCCGCACCCAGATTCAGCGCCTCGTGAAGCCAAGCTCTTCCGTAACAACAAAAGCCAAGCCGTCCGTATCCC
CGCAGACTTCGAGATGCCGGGGGATCGGGTGAACATCTATCGTGAGGGAAACCGGCTTATCATCGAGCCGGTGCGCCGCA
AGAACCTGCTTGAAGTGCTGGCCGGACTGGACCCGCTTGGGCCAGAAGATCAGTTTCCTGATGTGGACGAGACGCTTCTT
CCGGCCAAGGAAATCGACCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References