Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2953345..2953981 Replicon chromosome
Accession NZ_CP014795
Organism Bacillus licheniformis strain SCK B11

Toxin (Protein)


Gene name mazF Uniprot ID M5P3Q9
Locus tag BaDB11_RS15390 Protein ID WP_003179128.1
Coordinates 2953631..2953981 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M5PDU2
Locus tag BaDB11_RS15385 Protein ID WP_006638778.1
Coordinates 2953345..2953626 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BaDB11_RS15365 2948460..2949941 + 1482 WP_009330132.1 PH domain-containing protein -
BaDB11_RS15370 2949938..2950537 - 600 WP_003179118.1 rhomboid family intramembrane serine protease -
BaDB11_RS15375 2950880..2951839 + 960 WP_152847888.1 outer membrane lipoprotein carrier protein LolA -
BaDB11_RS15380 2952064..2953233 + 1170 WP_025807384.1 alanine racemase -
BaDB11_RS15385 2953345..2953626 + 282 WP_006638778.1 hypothetical protein Antitoxin
BaDB11_RS15390 2953631..2953981 + 351 WP_003179128.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
BaDB11_RS15395 2954099..2954926 + 828 WP_003179130.1 RsbT co-antagonist protein RsbRA -
BaDB11_RS15400 2954930..2955295 + 366 WP_003179132.1 STAS domain-containing protein -
BaDB11_RS15405 2955298..2955699 + 402 WP_003179135.1 anti-sigma regulatory factor -
BaDB11_RS15410 2955710..2956717 + 1008 WP_003179137.1 PP2C family protein-serine/threonine phosphatase -
BaDB11_RS15415 2956776..2957102 + 327 WP_003179140.1 anti-sigma factor antagonist -
BaDB11_RS15420 2957102..2957587 + 486 WP_003179142.1 anti-sigma B factor RsbW -
BaDB11_RS15425 2957553..2958344 + 792 WP_003179144.1 RNA polymerase sigma factor SigB -
BaDB11_RS15430 2958341..2958940 + 600 WP_003179145.1 SpoIIE family protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12990.03 Da        Isoelectric Point: 5.7234

>T61818 WP_003179128.1 NZ_CP014795:2953631-2953981 [Bacillus licheniformis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQISLALIDF

Download         Length: 351 bp

>T61818 NZ_CP014795:2953631-2953981 [Bacillus licheniformis]
TTGATTGTTAAACGCGGCGATGTTTATTTTGCTGACCTATCTCCTGTTGTTGGCTCAGAACAAGGCGGGGTGCGCCCGGT
TTTAGTGATTCAAAACAACATCGGCAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CAAAATTACCTACCCACGTCGAAATTGATGCGAAACGCTACGGTTTTGAAAGAGACTCCGTTATATTGCTCGAACAAATT
CGGACGATTGACAAGCAAAGATTAACGGACAAAATCACCCATCTCGATGATGAAATGATGGAAAAGGTCAACGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10649.03 Da        Isoelectric Point: 4.6920

>AT61818 WP_006638778.1 NZ_CP014795:2953345-2953626 [Bacillus licheniformis]
MSESSATTEILIRLPEALVSELDGVVMQDNGSRNELIYQATKMYLRERKNRQIRESMRRGYMEMAKINLNISSEAQFAEY
EAENTVERLVSGG

Download         Length: 282 bp

>AT61818 NZ_CP014795:2953345-2953626 [Bacillus licheniformis]
TTGTCTGAATCCAGCGCAACAACTGAAATATTGATTCGCTTGCCAGAAGCTTTAGTATCAGAACTGGATGGTGTCGTCAT
GCAAGATAACGGGAGCAGAAATGAACTGATTTACCAAGCCACAAAAATGTATTTACGCGAACGCAAAAATCGACAAATTC
GGGAATCGATGAGACGCGGTTATATGGAGATGGCCAAGATCAATTTGAACATCTCTTCTGAGGCTCAATTTGCAGAGTAT
GAGGCTGAAAACACAGTAGAGCGCTTAGTAAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I7FHI4

Antitoxin

Source ID Structure
AlphaFold DB M5PDU2

References