Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 4319033..4319669 Replicon chromosome
Accession NZ_CP014794
Organism Bacillus licheniformis strain SCCB 37

Toxin (Protein)


Gene name mazF Uniprot ID M5P3Q9
Locus tag B37_RS22370 Protein ID WP_003179128.1
Coordinates 4319319..4319669 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M5PDU2
Locus tag B37_RS22365 Protein ID WP_006638778.1
Coordinates 4319033..4319314 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B37_RS22345 4314148..4315629 + 1482 WP_009330132.1 PH domain-containing protein -
B37_RS22350 4315626..4316225 - 600 WP_003179118.1 rhomboid family intramembrane serine protease -
B37_RS22355 4316568..4317527 + 960 WP_152847888.1 outer membrane lipoprotein carrier protein LolA -
B37_RS22360 4317752..4318921 + 1170 WP_026080763.1 alanine racemase -
B37_RS22365 4319033..4319314 + 282 WP_006638778.1 hypothetical protein Antitoxin
B37_RS22370 4319319..4319669 + 351 WP_003179128.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
B37_RS22375 4319787..4320614 + 828 WP_061578564.1 RsbT co-antagonist protein RsbRA -
B37_RS22380 4320618..4320983 + 366 WP_003179132.1 STAS domain-containing protein -
B37_RS22385 4320986..4321387 + 402 WP_003179135.1 anti-sigma regulatory factor -
B37_RS22390 4321398..4322405 + 1008 WP_003179137.1 PP2C family protein-serine/threonine phosphatase -
B37_RS22395 4322464..4322790 + 327 WP_003179140.1 anti-sigma factor antagonist -
B37_RS22400 4322790..4323275 + 486 WP_003179142.1 anti-sigma B factor RsbW -
B37_RS22405 4323241..4324032 + 792 WP_003179144.1 RNA polymerase sigma factor SigB -
B37_RS22410 4324029..4324628 + 600 WP_003179145.1 SpoIIE family protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12990.03 Da        Isoelectric Point: 5.7234

>T61817 WP_003179128.1 NZ_CP014794:4319319-4319669 [Bacillus licheniformis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQISLALIDF

Download         Length: 351 bp

>T61817 NZ_CP014794:4319319-4319669 [Bacillus licheniformis]
TTGATTGTTAAACGCGGCGATGTTTATTTTGCTGACCTATCTCCTGTTGTTGGCTCAGAACAAGGCGGGGTGCGCCCGGT
TTTAGTGATTCAAAACAACATCGGCAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CAAAATTACCTACCCACGTCGAAATTGATGCGAAACGCTACGGTTTTGAAAGAGACTCCGTTATATTGCTCGAACAAATT
CGGACGATTGACAAGCAAAGATTAACGGACAAAATCACCCATCTCGATGATGAAATGATGGAAAAGGTCAACGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10649.03 Da        Isoelectric Point: 4.6920

>AT61817 WP_006638778.1 NZ_CP014794:4319033-4319314 [Bacillus licheniformis]
MSESSATTEILIRLPEALVSELDGVVMQDNGSRNELIYQATKMYLRERKNRQIRESMRRGYMEMAKINLNISSEAQFAEY
EAENTVERLVSGG

Download         Length: 282 bp

>AT61817 NZ_CP014794:4319033-4319314 [Bacillus licheniformis]
TTGTCTGAATCCAGCGCAACAACTGAAATATTGATTCGCTTGCCAGAAGCTTTAGTATCAGAACTGGATGGTGTCGTCAT
GCAAGATAACGGGAGCAGAAATGAACTGATTTACCAAGCCACAAAAATGTATTTACGCGAACGCAAAAATCGACAAATTC
GGGAATCGATGAGACGCGGTTATATGGAGATGGCCAAGATCAATTTGAACATCTCTTCTGAGGCTCAATTTGCAGAGTAT
GAGGCTGAAAACACAGTAGAGCGCTTAGTAAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I7FHI4

Antitoxin

Source ID Structure
AlphaFold DB M5PDU2

References