Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 4319033..4319669 Replicon chromosome
Accession NZ_CP014794
Organism Bacillus licheniformis strain SCCB 37

Toxin (Protein)


Gene name mazF Uniprot ID M5P3Q9
Locus tag B37_RS22370 Protein ID WP_003179128.1
Coordinates 4319319..4319669 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M5PDU2
Locus tag B37_RS22365 Protein ID WP_006638778.1
Coordinates 4319033..4319314 (+) Length 94 a.a.

Genomic Context

B37_RS22345B37_RS22355B37_RS22360B37_RS22365B37_RS22370B37_RS22375B37_RS22380B37_RS22385B37_RS22390B37_RS22395B37_RS22400B37_RS22405B37_RS22410B37_RS22350
Location: 4314148..4315629 (1482 bp)
Type: Others
Protein ID: WP_009330132.1
Location: 4316568..4317527 (960 bp)
Type: Others
Protein ID: WP_152847888.1
Location: 4317752..4318921 (1170 bp)
Type: Others
Protein ID: WP_026080763.1
Location: 4319033..4319314 (282 bp)
Type: Antitoxin
Protein ID: WP_006638778.1
Location: 4319319..4319669 (351 bp)
Type: Toxin
Protein ID: WP_003179128.1
Location: 4319787..4320614 (828 bp)
Type: Others
Protein ID: WP_061578564.1
Location: 4320618..4320983 (366 bp)
Type: Others
Protein ID: WP_003179132.1
Location: 4320986..4321387 (402 bp)
Type: Others
Protein ID: WP_003179135.1
Location: 4321398..4322405 (1008 bp)
Type: Others
Protein ID: WP_003179137.1
Location: 4322464..4322790 (327 bp)
Type: Others
Protein ID: WP_003179140.1
Location: 4322790..4323275 (486 bp)
Type: Others
Protein ID: WP_003179142.1
Location: 4323241..4324032 (792 bp)
Type: Others
Protein ID: WP_003179144.1
Location: 4324029..4324628 (600 bp)
Type: Others
Protein ID: WP_003179145.1
Location: 4315626..4316225 (600 bp)
Type: Others
Protein ID: WP_003179118.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
B37_RS223454314148..4315629+1482WP_009330132.1PH domain-containing protein-
B37_RS223504315626..4316225-600WP_003179118.1rhomboid family intramembrane serine protease-
B37_RS223554316568..4317527+960WP_152847888.1outer membrane lipoprotein carrier protein LolA-
B37_RS223604317752..4318921+1170WP_026080763.1alanine racemase-
B37_RS223654319033..4319314+282WP_006638778.1hypothetical proteinAntitoxin
B37_RS223704319319..4319669+351WP_003179128.1type II toxin-antitoxin system endoribonuclease NdoAToxin
B37_RS223754319787..4320614+828WP_061578564.1RsbT co-antagonist protein RsbRA-
B37_RS223804320618..4320983+366WP_003179132.1STAS domain-containing protein-
B37_RS223854320986..4321387+402WP_003179135.1anti-sigma regulatory factor-
B37_RS223904321398..4322405+1008WP_003179137.1PP2C family protein-serine/threonine phosphatase-
B37_RS223954322464..4322790+327WP_003179140.1anti-sigma factor antagonist-
B37_RS224004322790..4323275+486WP_003179142.1anti-sigma B factor RsbW-
B37_RS224054323241..4324032+792WP_003179144.1RNA polymerase sigma factor SigB-
B37_RS224104324029..4324628+600WP_003179145.1SpoIIE family protein phosphatase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12990.03 Da        Isoelectric Point: 5.7234

>T61817 WP_003179128.1 NZ_CP014794:4319319-4319669 [Bacillus licheniformis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQISLALIDF

Download         Length: 351 bp

>T61817 NZ_CP014794:4319319-4319669 [Bacillus licheniformis]
TTGATTGTTAAACGCGGCGATGTTTATTTTGCTGACCTATCTCCTGTTGTTGGCTCAGAACAAGGCGGGGTGCGCCCGGT
TTTAGTGATTCAAAACAACATCGGCAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CAAAATTACCTACCCACGTCGAAATTGATGCGAAACGCTACGGTTTTGAAAGAGACTCCGTTATATTGCTCGAACAAATT
CGGACGATTGACAAGCAAAGATTAACGGACAAAATCACCCATCTCGATGATGAAATGATGGAAAAGGTCAACGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10649.03 Da        Isoelectric Point: 4.6920

>AT61817 WP_006638778.1 NZ_CP014794:4319033-4319314 [Bacillus licheniformis]
MSESSATTEILIRLPEALVSELDGVVMQDNGSRNELIYQATKMYLRERKNRQIRESMRRGYMEMAKINLNISSEAQFAEY
EAENTVERLVSGG

Download         Length: 282 bp

>AT61817 NZ_CP014794:4319033-4319314 [Bacillus licheniformis]
TTGTCTGAATCCAGCGCAACAACTGAAATATTGATTCGCTTGCCAGAAGCTTTAGTATCAGAACTGGATGGTGTCGTCAT
GCAAGATAACGGGAGCAGAAATGAACTGATTTACCAAGCCACAAAAATGTATTTACGCGAACGCAAAAATCGACAAATTC
GGGAATCGATGAGACGCGGTTATATGGAGATGGCCAAGATCAATTTGAACATCTCTTCTGAGGCTCAATTTGCAGAGTAT
GAGGCTGAAAACACAGTAGAGCGCTTAGTAAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A6I7FHI4

Antitoxin

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Source
ID
Structure
AlphaFold DBM5PDU2

References