Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 4244018..4244937 Replicon chromosome
Accession NZ_CP014793
Organism Bacillus licheniformis strain SCDB 34

Toxin (Protein)


Gene name spoIISA Uniprot ID T5HIF3
Locus tag B34_RS22175 Protein ID WP_003180879.1
Coordinates 4244191..4244937 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID T5HT37
Locus tag B34_RS22170 Protein ID WP_003180877.1
Coordinates 4244018..4244191 (-) Length 58 a.a.

Genomic Context

B34_RS22150B34_RS22155B34_RS22160B34_RS22165B34_RS22190B34_RS22195B34_RS22170B34_RS22175B34_RS22180B34_RS22185
Location: 4239443..4240540 (1098 bp)
Type: Others
Protein ID: WP_003180867.1
Location: 4240516..4241364 (849 bp)
Type: Others
Protein ID: WP_003180869.1
Location: 4241391..4242404 (1014 bp)
Type: Others
Protein ID: WP_011197810.1
Location: 4242457..4243728 (1272 bp)
Type: Others
Protein ID: WP_009328725.1
Location: 4247008..4248765 (1758 bp)
Type: Others
Protein ID: WP_011197813.1
Location: 4248894..4249537 (644 bp)
Type: Others
Protein ID: Protein_4306
Location: 4244018..4244191 (174 bp)
Type: Antitoxin
Protein ID: WP_003180877.1
Location: 4244191..4244937 (747 bp)
Type: Toxin
Protein ID: WP_003180879.1
Location: 4245048..4246046 (999 bp)
Type: Others
Protein ID: WP_009328723.1
Location: 4246059..4246676 (618 bp)
Type: Others
Protein ID: WP_003180884.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
B34_RS221504239443..4240540+1098WP_003180867.1mannonate dehydratase-
B34_RS221554240516..4241364+849WP_003180869.1SDR family oxidoreductase-
B34_RS221604241391..4242404+1014WP_011197810.1zinc-binding alcohol dehydrogenase family protein-
B34_RS221654242457..4243728+1272WP_009328725.1MFS transporter-
B34_RS221704244018..4244191-174WP_003180877.1type II toxin-antitoxin system SpoIISB family antitoxinAntitoxin
B34_RS221754244191..4244937-747WP_003180879.1type II toxin-antitoxin system SpoIISA family toxinToxin
B34_RS221804245048..4246046-999WP_009328723.1inorganic phosphate transporter-
B34_RS221854246059..4246676-618WP_003180884.1DUF47 domain-containing protein-
B34_RS221904247008..4248765+1758WP_011197813.1gamma-glutamyltransferase-
B34_RS221954248894..4249537+644Protein_4306DUF624 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-57)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29391.80 Da        Isoelectric Point: 4.5367

>T61815 WP_003180879.1 NZ_CP014793:c4244937-4244191 [Bacillus licheniformis]
MLLFYQFLVWLIVLALALYVAAVWRFEKQLAEKTVAIRKTWYLLYVIGAVIYWTHDPQSIFTNPLHYLIVAVFFTLTDAF
IFLNAYFKKLGSSELATDTRMLLEENNDLLHTYQNRLKTFQYLLKNEPIHIYYGNIEAYAEGIEKLIKRFAEKMNISAAL
CEYNSEESKDHLLEHMENRFDVQEKLDRKDVYYEENGKMVLIPFSIHDFDYVMKLTSEDLVTEFDYLLFTSLTSIYDLLL
PNEEEGDD

Download         Length: 747 bp

>T61815 NZ_CP014793:c4244937-4244191 [Bacillus licheniformis]
ATGCTGCTATTTTATCAATTCCTTGTTTGGCTTATTGTTTTGGCGCTGGCTCTGTACGTAGCTGCCGTGTGGCGTTTTGA
AAAACAGCTCGCCGAAAAAACGGTCGCCATCAGAAAAACGTGGTACCTTCTTTATGTCATCGGCGCCGTGATATATTGGA
CGCACGATCCGCAGTCAATTTTCACAAACCCGCTTCATTACCTGATCGTTGCCGTTTTTTTCACGTTGACAGACGCTTTT
ATTTTCTTAAATGCCTACTTTAAAAAGCTCGGCAGCTCTGAACTCGCGACAGATACAAGAATGCTTCTCGAAGAAAACAA
CGACCTCCTCCACACGTATCAAAACAGGCTGAAAACGTTTCAATACCTATTGAAAAACGAACCGATCCACATCTATTATG
GAAATATAGAAGCGTATGCAGAAGGCATCGAAAAGCTCATCAAACGGTTTGCCGAAAAAATGAATATATCCGCTGCACTT
TGCGAATATAATTCAGAAGAAAGCAAGGATCATTTGCTTGAGCATATGGAAAACCGGTTCGATGTTCAAGAAAAGCTTGA
CCGCAAAGACGTTTATTATGAAGAAAACGGAAAAATGGTCCTCATTCCTTTTTCCATCCACGATTTTGACTATGTCATGA
AGTTAACCTCAGAAGACCTTGTCACAGAATTTGATTATCTCCTGTTTACTTCTTTAACAAGCATCTATGATCTTCTGCTA
CCAAACGAAGAGGAAGGTGACGACTGA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6945.04 Da        Isoelectric Point: 10.9186

>AT61815 WP_003180877.1 NZ_CP014793:c4244191-4244018 [Bacillus licheniformis]
MEPAFQQDQESVKKRLAFKMFKRQSKTNIAKYEVSPHTERIFRQNERLIGEYKRKKA

Download         Length: 174 bp

>AT61815 NZ_CP014793:c4244191-4244018 [Bacillus licheniformis]
ATGGAGCCTGCTTTTCAGCAAGACCAGGAAAGCGTAAAAAAGCGCCTCGCCTTTAAAATGTTTAAAAGGCAATCCAAAAC
CAATATCGCGAAATACGAAGTCAGCCCCCATACCGAACGGATTTTCCGGCAAAACGAACGGCTGATCGGCGAGTATAAAA
GAAAAAAAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBT5HIF3

Antitoxin

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Source
ID
Structure
AlphaFold DBT5HT37

References