Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3381879..3382515 Replicon chromosome
Accession NZ_CP014793
Organism Bacillus licheniformis strain SCDB 34

Toxin (Protein)


Gene name mazF Uniprot ID M5P3Q9
Locus tag B34_RS17655 Protein ID WP_003179128.1
Coordinates 3382165..3382515 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M5PDU2
Locus tag B34_RS17650 Protein ID WP_006638778.1
Coordinates 3381879..3382160 (+) Length 94 a.a.

Genomic Context

B34_RS17630B34_RS17640B34_RS17645B34_RS17650B34_RS17655B34_RS17660B34_RS17665B34_RS17670B34_RS17675B34_RS17680B34_RS17685B34_RS17690B34_RS17695B34_RS17635
Location: 3376994..3378475 (1482 bp)
Type: Others
Protein ID: WP_009330132.1
Location: 3379414..3380373 (960 bp)
Type: Others
Protein ID: WP_152847888.1
Location: 3380598..3381767 (1170 bp)
Type: Others
Protein ID: WP_026080763.1
Location: 3381879..3382160 (282 bp)
Type: Antitoxin
Protein ID: WP_006638778.1
Location: 3382165..3382515 (351 bp)
Type: Toxin
Protein ID: WP_003179128.1
Location: 3382633..3383460 (828 bp)
Type: Others
Protein ID: WP_061578564.1
Location: 3383464..3383829 (366 bp)
Type: Others
Protein ID: WP_003179132.1
Location: 3383832..3384233 (402 bp)
Type: Others
Protein ID: WP_003179135.1
Location: 3384244..3385251 (1008 bp)
Type: Others
Protein ID: WP_003179137.1
Location: 3385310..3385636 (327 bp)
Type: Others
Protein ID: WP_003179140.1
Location: 3385636..3386121 (486 bp)
Type: Others
Protein ID: WP_003179142.1
Location: 3386087..3386878 (792 bp)
Type: Others
Protein ID: WP_003179144.1
Location: 3386875..3387474 (600 bp)
Type: Others
Protein ID: WP_003179145.1
Location: 3378472..3379071 (600 bp)
Type: Others
Protein ID: WP_003179118.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
B34_RS176303376994..3378475+1482WP_009330132.1PH domain-containing protein-
B34_RS176353378472..3379071-600WP_003179118.1rhomboid family intramembrane serine protease-
B34_RS176403379414..3380373+960WP_152847888.1outer membrane lipoprotein carrier protein LolA-
B34_RS176453380598..3381767+1170WP_026080763.1alanine racemase-
B34_RS176503381879..3382160+282WP_006638778.1hypothetical proteinAntitoxin
B34_RS176553382165..3382515+351WP_003179128.1type II toxin-antitoxin system endoribonuclease NdoAToxin
B34_RS176603382633..3383460+828WP_061578564.1RsbT co-antagonist protein RsbRA-
B34_RS176653383464..3383829+366WP_003179132.1STAS domain-containing protein-
B34_RS176703383832..3384233+402WP_003179135.1anti-sigma regulatory factor-
B34_RS176753384244..3385251+1008WP_003179137.1PP2C family protein-serine/threonine phosphatase-
B34_RS176803385310..3385636+327WP_003179140.1anti-sigma factor antagonist-
B34_RS176853385636..3386121+486WP_003179142.1anti-sigma B factor RsbW-
B34_RS176903386087..3386878+792WP_003179144.1RNA polymerase sigma factor SigB-
B34_RS176953386875..3387474+600WP_003179145.1SpoIIE family protein phosphatase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12990.03 Da        Isoelectric Point: 5.7234

>T61814 WP_003179128.1 NZ_CP014793:3382165-3382515 [Bacillus licheniformis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQISLALIDF

Download         Length: 351 bp

>T61814 NZ_CP014793:3382165-3382515 [Bacillus licheniformis]
TTGATTGTTAAACGCGGCGATGTTTATTTTGCTGACCTATCTCCTGTTGTTGGCTCAGAACAAGGCGGGGTGCGCCCGGT
TTTAGTGATTCAAAACAACATCGGCAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CAAAATTACCTACCCACGTCGAAATTGATGCGAAACGCTACGGTTTTGAAAGAGACTCCGTTATATTGCTCGAACAAATT
CGGACGATTGACAAGCAAAGATTAACGGACAAAATCACCCATCTCGATGATGAAATGATGGAAAAGGTCAACGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10649.03 Da        Isoelectric Point: 4.6920

>AT61814 WP_006638778.1 NZ_CP014793:3381879-3382160 [Bacillus licheniformis]
MSESSATTEILIRLPEALVSELDGVVMQDNGSRNELIYQATKMYLRERKNRQIRESMRRGYMEMAKINLNISSEAQFAEY
EAENTVERLVSGG

Download         Length: 282 bp

>AT61814 NZ_CP014793:3381879-3382160 [Bacillus licheniformis]
TTGTCTGAATCCAGCGCAACAACTGAAATATTGATTCGCTTGCCAGAAGCTTTAGTATCAGAACTGGATGGTGTCGTCAT
GCAAGATAACGGGAGCAGAAATGAACTGATTTACCAAGCCACAAAAATGTATTTACGCGAACGCAAAAATCGACAAATTC
GGGAATCGATGAGACGCGGTTATATGGAGATGGCCAAGATCAATTTGAACATCTCTTCTGAGGCTCAATTTGCAGAGTAT
GAGGCTGAAAACACAGTAGAGCGCTTAGTAAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A6I7FHI4

Antitoxin

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Source
ID
Structure
AlphaFold DBM5PDU2

References