Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 806723..807200 Replicon chromosome
Accession NZ_CP014791
Organism Staphylococcus aureus strain MCRF184

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag CKU_RS03885 Protein ID WP_000052076.1
Coordinates 806723..806911 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CKU_RS03890 Protein ID WP_001059690.1
Coordinates 806940..807200 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKU_RS03855 802713..803234 + 522 WP_000824479.1 hypothetical protein -
CKU_RS03860 803575..804261 + 687 WP_001622483.1 thermonuclease family protein -
CKU_RS03865 804618..804818 + 201 WP_001059082.1 cold-shock protein -
CKU_RS03870 805315..805533 - 219 WP_000005875.1 hypothetical protein -
CKU_RS03875 805606..805878 - 273 WP_001004400.1 hypothetical protein -
CKU_RS03880 805966..806535 - 570 WP_001106662.1 hypothetical protein -
CKU_RS03885 806723..806911 - 189 WP_000052076.1 hypothetical protein Toxin
CKU_RS03890 806940..807200 - 261 WP_001059690.1 hypothetical protein Antitoxin
CKU_RS03895 807541..807744 + 204 WP_000145160.1 sterile alpha motif-like domain-containing protein -
CKU_RS03900 807741..807977 - 237 WP_000368687.1 hypothetical protein -
CKU_RS03905 808201..808782 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
CKU_RS03910 808855..809472 - 618 WP_000255550.1 LysE/ArgO family amino acid transporter -
CKU_RS03915 809628..810122 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
CKU_RS03920 810521..810943 - 423 WP_000974451.1 organic hydroperoxide resistance protein -
CKU_RS03925 811091..811807 + 717 WP_000150033.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(1-39)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T61806 WP_000052076.1 NZ_CP014791:c806911-806723 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T61806 NZ_CP014791:c806911-806723 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT61806 WP_001059690.1 NZ_CP014791:c807200-806940 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT61806 NZ_CP014791:c807200-806940 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References