Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 3497799..3499200 Replicon chromosome
Accession NZ_CP014784
Organism Pseudomonas alcaligenes strain NEB 585

Toxin (Protein)


Gene name - Uniprot ID A0A142IU22
Locus tag A0T30_RS16035 Protein ID WP_061904964.1
Coordinates 3498631..3499200 (-) Length 190 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A142IU21
Locus tag A0T30_RS16030 Protein ID WP_061904963.1
Coordinates 3497799..3498626 (-) Length 276 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A0T30_RS16005 3493155..3494075 + 921 WP_061904958.1 recombination-associated protein RdgC -
A0T30_RS16010 3494240..3494554 + 315 WP_061904959.1 quaternary ammonium compound efflux SMR transporter SugE -
A0T30_RS16015 3494607..3496505 - 1899 WP_061904960.1 MFS transporter -
A0T30_RS16020 3496697..3497026 - 330 WP_061904961.1 AzlD domain-containing protein -
A0T30_RS16025 3497026..3497736 - 711 WP_061904962.1 AzlC family ABC transporter permease -
A0T30_RS16030 3497799..3498626 - 828 WP_061904963.1 AraC family transcriptional regulator Antitoxin
A0T30_RS16035 3498631..3499200 - 570 WP_061904964.1 GNAT family N-acetyltransferase Toxin
A0T30_RS16040 3499366..3502836 + 3471 WP_061904965.1 hybrid sensor histidine kinase/response regulator -
A0T30_RS16045 3503035..3503733 + 699 WP_061904966.1 pirin-like bicupin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(14-146)

Antitoxin

DNA binding HTH domain, AraC-type

(193-270)


Sequences

Toxin        


Download         Length: 190 a.a.        Molecular weight: 21212.28 Da        Isoelectric Point: 9.5851

>T61804 WP_061904964.1 NZ_CP014784:c3499200-3498631 [Pseudomonas alcaligenes]
MFKPQPVALQQGALRLDPLTEADLPGLLQLAEANRASQQFMSGTTRPDWYRSALAEQREGREVVFAIRLAGELVGTTSFF
DFNLVLPAAEIGATWLDVGQHGTGLNRMIKYLMLRHAFEEWQLVRVQLKTAASNLRAQRAIEKLGAQREGLLRNHRRLAD
GRLDHTVMYSITDSEWPQVKAGLEARFGA

Download         Length: 570 bp

>T61804 NZ_CP014784:c3499200-3498631 [Pseudomonas alcaligenes]
ATGTTCAAGCCCCAACCCGTCGCCCTGCAGCAGGGCGCCCTGCGCCTCGATCCGCTGACCGAGGCCGACCTGCCGGGCCT
GCTGCAGCTGGCCGAGGCCAACCGCGCATCGCAGCAGTTCATGAGTGGCACGACCCGCCCGGACTGGTACCGCAGCGCCC
TGGCCGAGCAGCGCGAGGGCCGCGAGGTGGTGTTCGCCATCCGCCTGGCCGGCGAGCTGGTCGGCACCACCAGCTTCTTC
GACTTCAACTTGGTGCTGCCGGCCGCCGAGATCGGTGCCACCTGGCTCGACGTGGGCCAGCACGGCACTGGCCTGAACCG
CATGATCAAGTACCTGATGCTGCGCCACGCCTTCGAGGAGTGGCAGCTGGTGCGCGTGCAGCTGAAGACCGCCGCCAGCA
ACCTGCGCGCGCAGCGTGCCATCGAGAAGCTCGGTGCCCAGCGCGAGGGTTTGCTGCGCAACCACCGGCGCCTGGCCGAC
GGGCGCCTCGACCACACCGTGATGTACAGCATCACCGACAGCGAGTGGCCGCAGGTCAAGGCCGGGCTGGAGGCGCGCTT
CGGCGCGTGA

Antitoxin


Download         Length: 276 a.a.        Molecular weight: 30628.89 Da        Isoelectric Point: 8.7306

>AT61804 WP_061904963.1 NZ_CP014784:c3498626-3497799 [Pseudomonas alcaligenes]
MAGGEQTRFWESQALTGVELLHARYIEQRFAPHVHEGFVFTVIEGGAQRFRHRGSDHLAPVGSMVLINPDEVHTGSKAHE
QGWWYRGFYPAPAQVQGVLAELELADRGMPSFGASVLQDLELHQAFGRLHRLLDGEACTLQQQTAWREAILLLFQRHARI
PQAREPGAEPRAVAMAKELLAARLGEPPSLEELAGLVNLSPFHFARVFRRATGLPPHAWLKQRRLEQARALLRSGCAPLQ
VALQLGFADQSHLNRQFKQSYGVSPGEYRRACAGG

Download         Length: 828 bp

>AT61804 NZ_CP014784:c3498626-3497799 [Pseudomonas alcaligenes]
TTGGCTGGCGGCGAGCAGACCCGCTTCTGGGAGAGTCAGGCGCTGACAGGCGTCGAGTTGCTGCACGCGCGCTACATCGA
GCAGCGTTTCGCCCCGCATGTGCACGAAGGCTTTGTGTTCACCGTGATCGAAGGTGGCGCCCAGCGCTTCCGCCATCGTG
GCAGTGATCACCTGGCGCCGGTCGGCAGCATGGTGCTGATCAACCCGGATGAGGTGCATACCGGTTCCAAGGCGCACGAG
CAGGGCTGGTGGTACCGCGGCTTCTATCCGGCGCCGGCGCAGGTGCAGGGCGTACTGGCGGAGCTGGAGCTGGCGGATCG
CGGCATGCCGTCCTTCGGCGCCAGCGTGCTGCAGGACCTGGAGCTGCATCAGGCCTTCGGCAGGTTGCATCGCCTGCTCG
ATGGCGAGGCGTGCACCCTGCAGCAGCAGACGGCCTGGCGCGAGGCGATCCTGCTGCTATTTCAGCGCCATGCGCGCATC
CCGCAGGCGCGCGAGCCCGGCGCCGAGCCGCGGGCCGTGGCAATGGCCAAGGAGCTGCTGGCGGCGCGCCTGGGCGAGCC
GCCCTCGCTGGAAGAGCTGGCCGGGCTGGTGAATCTGTCGCCGTTCCACTTCGCCCGCGTGTTCCGCCGCGCCACCGGCC
TGCCGCCGCATGCCTGGCTCAAGCAGCGCCGCCTGGAGCAGGCGCGGGCGCTGCTGCGCTCCGGCTGCGCGCCGCTGCAG
GTGGCGCTGCAGCTGGGCTTCGCCGACCAGAGCCACCTGAACCGGCAGTTCAAGCAGAGCTACGGTGTCAGCCCCGGCGA
GTATCGCCGCGCCTGCGCGGGCGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A142IU22

Antitoxin

Source ID Structure
AlphaFold DB A0A142IU21

References