Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 561671..562307 Replicon chromosome
Accession NZ_CP014781
Organism Bacillus licheniformis strain HRBL-15TDI7

Toxin (Protein)


Gene name mazF Uniprot ID M5P3Q9
Locus tag AB684_RS02770 Protein ID WP_003179128.1
Coordinates 561957..562307 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M5PDU2
Locus tag AB684_RS02765 Protein ID WP_006638778.1
Coordinates 561671..561952 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB684_RS02745 556786..558267 + 1482 WP_009330132.1 PH domain-containing protein -
AB684_RS02750 558264..558863 - 600 WP_003179118.1 rhomboid family intramembrane serine protease -
AB684_RS02755 559206..560165 + 960 WP_152847888.1 outer membrane lipoprotein carrier protein LolA -
AB684_RS02760 560390..561559 + 1170 WP_025807384.1 alanine racemase -
AB684_RS02765 561671..561952 + 282 WP_006638778.1 hypothetical protein Antitoxin
AB684_RS02770 561957..562307 + 351 WP_003179128.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
AB684_RS02775 562425..563252 + 828 WP_061578564.1 RsbT co-antagonist protein RsbRA -
AB684_RS02780 563256..563621 + 366 WP_003179132.1 STAS domain-containing protein -
AB684_RS02785 563624..564025 + 402 WP_003179135.1 anti-sigma regulatory factor -
AB684_RS02790 564036..565043 + 1008 WP_003179137.1 PP2C family protein-serine/threonine phosphatase -
AB684_RS02795 565102..565428 + 327 WP_003179140.1 anti-sigma factor antagonist -
AB684_RS02800 565428..565913 + 486 WP_003179142.1 anti-sigma B factor RsbW -
AB684_RS02805 565879..566670 + 792 WP_003179144.1 RNA polymerase sigma factor SigB -
AB684_RS02810 566667..567266 + 600 WP_003179145.1 SpoIIE family protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12990.03 Da        Isoelectric Point: 5.7234

>T61797 WP_003179128.1 NZ_CP014781:561957-562307 [Bacillus licheniformis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQISLALIDF

Download         Length: 351 bp

>T61797 NZ_CP014781:561957-562307 [Bacillus licheniformis]
TTGATTGTTAAACGCGGCGATGTTTATTTTGCTGACCTATCTCCTGTTGTTGGCTCAGAACAAGGCGGGGTGCGCCCGGT
TTTAGTGATTCAAAACAACATCGGCAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CAAAATTACCTACCCACGTCGAAATTGATGCGAAACGCTACGGTTTTGAAAGAGACTCCGTTATATTGCTCGAACAAATT
CGGACGATTGACAAGCAAAGATTAACGGACAAAATCACCCATCTCGATGATGAAATGATGGAAAAGGTCAACGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10649.03 Da        Isoelectric Point: 4.6920

>AT61797 WP_006638778.1 NZ_CP014781:561671-561952 [Bacillus licheniformis]
MSESSATTEILIRLPEALVSELDGVVMQDNGSRNELIYQATKMYLRERKNRQIRESMRRGYMEMAKINLNISSEAQFAEY
EAENTVERLVSGG

Download         Length: 282 bp

>AT61797 NZ_CP014781:561671-561952 [Bacillus licheniformis]
TTGTCTGAATCCAGCGCAACAACTGAAATATTGATTCGCTTGCCAGAAGCTTTAGTATCAGAACTGGATGGTGTCGTCAT
GCAAGATAACGGGAGCAGAAATGAACTGATTTACCAAGCCACAAAAATGTATTTACGCGAACGCAAAAATCGACAAATTC
GGGAATCGATGAGACGCGGTTATATGGAGATGGCCAAGATCAATTTGAACATCTCTTCTGAGGCTCAATTTGCAGAGTAT
GAGGCTGAAAACACAGTAGAGCGCTTAGTAAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I7FHI4

Antitoxin

Source ID Structure
AlphaFold DB M5PDU2

References