Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 2455992..2456575 Replicon chromosome
Accession NZ_CP014771
Organism Hymenobacter sp. PAMC 26554

Toxin (Protein)


Gene name mazE Uniprot ID A0A142HF03
Locus tag A0257_RS11400 Protein ID WP_068337757.1
Coordinates 2455992..2456321 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazF Uniprot ID A0A142HF04
Locus tag A0257_RS11405 Protein ID WP_068337759.1
Coordinates 2456315..2456575 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A0257_RS11380 2451763..2452362 + 600 WP_157550378.1 TIGR04282 family arsenosugar biosynthesis glycosyltransferase -
A0257_RS11385 2452496..2453953 + 1458 WP_068337750.1 FAD-dependent oxidoreductase -
A0257_RS11390 2453915..2455012 - 1098 WP_068337752.1 ISAs1 family transposase -
A0257_RS11395 2455203..2455925 - 723 WP_068337755.1 TIGR04283 family arsenosugar biosynthesis glycosyltransferase -
A0257_RS11400 2455992..2456321 - 330 WP_068337757.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
A0257_RS11405 2456315..2456575 - 261 WP_068337759.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
A0257_RS25100 2456621..2457241 + 621 WP_157550379.1 hypothetical protein -
A0257_RS11410 2457380..2459272 + 1893 WP_068337761.1 30S ribosomal protein S1 -
A0257_RS11420 2459517..2459774 - 258 WP_157550380.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-104)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12172.09 Da        Isoelectric Point: 9.8031

>T61793 WP_068337757.1 NZ_CP014771:c2456321-2455992 [Hymenobacter sp. PAMC 26554]
MVAAPQRFEVWLVNLDPTQGSEINKTRPCVVISPDELNRHLRTVTITALTSSQRAYPSRVDCKFQGKAGQVALDHIRSVD
KTRLVRKLGALEAVTAQAVCARLVELFHY

Download         Length: 330 bp

>T61793 NZ_CP014771:c2456321-2455992 [Hymenobacter sp. PAMC 26554]
ATGGTAGCCGCGCCCCAGCGCTTCGAGGTATGGCTGGTGAACCTCGACCCCACGCAAGGCAGCGAAATCAACAAAACGCG
GCCGTGCGTAGTCATTTCGCCCGATGAGCTGAACCGCCACCTGCGCACCGTTACCATTACGGCGCTCACGAGTAGCCAGC
GCGCTTACCCGTCGCGGGTCGATTGCAAGTTTCAGGGCAAAGCCGGGCAGGTAGCGCTCGACCACATCCGGTCGGTGGAT
AAAACGCGTCTGGTGCGCAAGCTGGGGGCTTTGGAAGCGGTTACGGCGCAGGCAGTTTGCGCCCGGCTTGTAGAGTTGTT
TCACTACTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9700.00 Da        Isoelectric Point: 4.4131

>AT61793 WP_068337759.1 NZ_CP014771:c2456575-2456315 [Hymenobacter sp. PAMC 26554]
MHTRIIRVGNSQGIVLPKKLLQQYHLSGEVDLRPTPDGLLIAPVMRSARVNWEAQMQAALAVGQEPEGELLEGFSDADFE
ETEWQW

Download         Length: 261 bp

>AT61793 NZ_CP014771:c2456575-2456315 [Hymenobacter sp. PAMC 26554]
ATGCACACCCGTATTATCCGCGTCGGCAACTCGCAAGGTATTGTGTTGCCCAAGAAACTGCTGCAACAGTACCACCTAAG
CGGCGAAGTTGACCTGCGCCCTACCCCCGATGGATTGCTCATTGCTCCGGTAATGCGCTCAGCCAGAGTAAACTGGGAGG
CCCAGATGCAAGCCGCCCTAGCCGTCGGCCAGGAGCCGGAAGGCGAATTGCTGGAAGGCTTCTCGGATGCCGATTTTGAG
GAAACCGAGTGGCAATGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A142HF03

Antitoxin

Source ID Structure
AlphaFold DB A0A142HF04

References