Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
Location | 39017..39542 | Replicon | plasmid pKpQIL-9b8 |
Accession | NZ_CP014765 | ||
Organism | Klebsiella pneumoniae strain KPNIH39 |
Toxin (Protein)
Gene name | ccdB | Uniprot ID | W8UQV6 |
Locus tag | WM47_RS28625 | Protein ID | WP_001568026.1 |
Coordinates | 39237..39542 (+) | Length | 102 a.a. |
Antitoxin (Protein)
Gene name | ccdA | Uniprot ID | W8V2V6 |
Locus tag | WM47_RS28620 | Protein ID | WP_001568025.1 |
Coordinates | 39017..39235 (+) | Length | 73 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
WM47_RS28575 | 34407..34610 | - | 204 | WP_004197809.1 | hypothetical protein | - |
WM47_RS28580 | 34624..34827 | - | 204 | WP_004197808.1 | hemolysin expression modulator Hha | - |
WM47_RS28585 | 34861..35229 | - | 369 | WP_004197807.1 | hypothetical protein | - |
WM47_RS28590 | 35273..35767 | - | 495 | WP_020805591.1 | hypothetical protein | - |
WM47_RS28595 | 35798..36370 | - | 573 | WP_020805590.1 | hypothetical protein | - |
WM47_RS28600 | 36367..36615 | - | 249 | WP_000272716.1 | hypothetical protein | - |
WM47_RS28605 | 37052..37741 | + | 690 | WP_020315560.1 | RES family NAD+ phosphorylase | - |
WM47_RS28610 | 37773..38462 | - | 690 | WP_004193995.1 | hypothetical protein | - |
WM47_RS31590 | 38602..38847 | + | 246 | Protein_41 | hypothetical protein | - |
WM47_RS28620 | 39017..39235 | + | 219 | WP_001568025.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
WM47_RS28625 | 39237..39542 | + | 306 | WP_001568026.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
WM47_RS28630 | 39711..40106 | + | 396 | WP_072158608.1 | hypothetical protein | - |
WM47_RS28635 | 40133..40456 | + | 324 | WP_022644730.1 | hypothetical protein | - |
WM47_RS28640 | 40453..41469 | + | 1017 | WP_020315256.1 | hypothetical protein | - |
WM47_RS28645 | 41804..43072 | - | 1269 | WP_019705993.1 | ISL3 family transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | blaKPC-3 | - | 1..106559 | 106559 | |
- | flank | IS/Tn | - | - | 41804..43072 | 1268 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11645.32 Da Isoelectric Point: 5.6919
>T61792 WP_001568026.1 NZ_CP014765:39237-39542 [Klebsiella pneumoniae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASAWLLSDKVSRELYPVVHIGDESYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASAWLLSDKVSRELYPVVHIGDESYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI
Download Length: 306 bp
>T61792 NZ_CP014765:39237-39542 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCTGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGACGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCTGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGACGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8392.34 Da Isoelectric Point: 4.7405
>AT61792 WP_001568025.1 NZ_CP014765:39017-39235 [Klebsiella pneumoniae]
MKQRITVTIDSDSYQLLKSADVNISALVNRAMQNEARRLRSERWQAENQEGMAEVARFIEMNGSFADENRDW
MKQRITVTIDSDSYQLLKSADVNISALVNRAMQNEARRLRSERWQAENQEGMAEVARFIEMNGSFADENRDW
Download Length: 219 bp
>AT61792 NZ_CP014765:39017-39235 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACTGTCACCATAGACAGTGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA
ATGAAGCAGCGCATCACTGTCACCATAGACAGTGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A514EZN1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2J4ZZP8 |