Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4493695..4494352 Replicon chromosome
Accession NZ_CP014762
Organism Klebsiella pneumoniae strain KPNIH39

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag WM47_RS22425 Protein ID WP_002916310.1
Coordinates 4493695..4494105 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag WM47_RS22430 Protein ID WP_002916312.1
Coordinates 4494086..4494352 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WM47_RS22405 4489695..4491428 - 1734 WP_023328361.1 single-stranded-DNA-specific exonuclease RecJ -
WM47_RS22410 4491434..4492147 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
WM47_RS22415 4492170..4493066 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
WM47_RS22420 4493167..4493688 + 522 WP_004144730.1 flavodoxin FldB -
WM47_RS22425 4493695..4494105 - 411 WP_002916310.1 protein YgfX Toxin
WM47_RS22430 4494086..4494352 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
WM47_RS22435 4494598..4495581 + 984 WP_064798451.1 tRNA-modifying protein YgfZ -
WM47_RS22440 4495732..4496391 - 660 WP_002916317.1 hemolysin III family protein -
WM47_RS22445 4496555..4496866 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
WM47_RS22450 4496916..4497644 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
WM47_RS22455 4497763..4499196 + 1434 WP_064798452.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T61784 WP_002916310.1 NZ_CP014762:c4494105-4493695 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T61784 NZ_CP014762:c4494105-4493695 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT61784 WP_002916312.1 NZ_CP014762:c4494352-4494086 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT61784 NZ_CP014762:c4494352-4494086 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References