Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 568812..569328 Replicon chromosome
Accession NZ_CP014762
Organism Klebsiella pneumoniae strain KPNIH39

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag WM47_RS02880 Protein ID WP_004178374.1
Coordinates 569044..569328 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag WM47_RS02875 Protein ID WP_002886901.1
Coordinates 568812..569054 (+) Length 81 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WM47_RS02860 564840..565580 + 741 WP_004186692.1 KDGP aldolase family protein -
WM47_RS02865 565647..566801 + 1155 WP_002886900.1 lactonase family protein -
WM47_RS02870 566824..568734 + 1911 WP_031593171.1 BglG family transcription antiterminator -
WM47_RS02875 568812..569054 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
WM47_RS02880 569044..569328 + 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WM47_RS02885 569332..569796 - 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
WM47_RS02890 570037..572175 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
WM47_RS02900 572532..573275 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
WM47_RS31655 573278..573451 - 174 WP_019725541.1 hypothetical protein -
WM47_RS02910 573536..573844 + 309 WP_012737232.1 PTS sugar transporter subunit IIB -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T61770 WP_004178374.1 NZ_CP014762:569044-569328 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T61770 NZ_CP014762:569044-569328 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT61770 WP_002886901.1 NZ_CP014762:568812-569054 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT61770 NZ_CP014762:568812-569054 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A6THG1


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References