Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prpT-prpA/CC2985(antitoxin)
Location 2368516..2369056 Replicon chromosome
Accession NZ_CP014760
Organism Legionella pneumophila strain F4469

Toxin (Protein)


Gene name PrpT Uniprot ID -
Locus tag A1D14_RS10905 Protein ID WP_014844324.1
Coordinates 2368760..2369056 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name PrpA Uniprot ID -
Locus tag A1D14_RS10900 Protein ID WP_027224835.1
Coordinates 2368516..2368770 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A1D14_RS10880 2364420..2365595 - 1176 WP_027224832.1 ISL3 family transposase -
A1D14_RS10885 2365634..2366764 - 1131 WP_064319116.1 ISL3 family transposase -
A1D14_RS10890 2366919..2367497 + 579 WP_027224833.1 hypothetical protein -
A1D14_RS10895 2367602..2368168 + 567 WP_027224834.1 hypothetical protein -
A1D14_RS10900 2368516..2368770 + 255 WP_027224835.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
A1D14_RS10905 2368760..2369056 + 297 WP_014844324.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A1D14_RS10915 2369517..2370531 - 1015 Protein_2088 transposase -
A1D14_RS10920 2370794..2371003 + 210 WP_010947832.1 cold-shock protein -
A1D14_RS10925 2371243..2372649 + 1407 WP_014844326.1 ATP-dependent RNA helicase DbpA -
A1D14_RS10930 2372806..2373717 + 912 WP_014844327.1 cation diffusion facilitator family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2300058..2369302 69244


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-94)

Antitoxin

Antitoxin ParD

(1-81)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11582.28 Da        Isoelectric Point: 7.2728

>T61766 WP_014844324.1 NZ_CP014760:2368760-2369056 [Legionella pneumophila]
MSNKTYRLYPKAVEDLESIYLYSTNEFGIKRTEDYILAIDLSFQRLADDPLIARKCDYIRPELRAFNVGSHIIFFKTTDY
GISVIRVLHQSMDFNRHL

Download         Length: 297 bp

>T61766 NZ_CP014760:2368760-2369056 [Legionella pneumophila]
ATGTCAAATAAAACATATCGTCTTTACCCAAAAGCGGTAGAAGATCTTGAGTCCATCTATTTATATAGCACAAATGAGTT
TGGTATCAAACGAACAGAGGATTATATTTTAGCTATAGATTTAAGTTTTCAGCGCCTTGCAGATGATCCCTTAATTGCTC
GAAAATGTGATTATATTCGTCCAGAATTACGCGCATTTAATGTTGGCTCTCACATTATTTTTTTCAAAACTACCGATTAC
GGCATTTCTGTTATTCGAGTGTTGCATCAATCTATGGATTTTAATAGACATCTATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9786.14 Da        Isoelectric Point: 9.9613

>AT61766 WP_027224835.1 NZ_CP014760:2368516-2368770 [Legionella pneumophila]
MTRTMTVDLGNELRNYVESLVRSGDYRSNSEVLRESLRLLREKQAESKLEQLRHLIDEGAASGKPETWDAHDFLKKMKKK
SHVK

Download         Length: 255 bp

>AT61766 NZ_CP014760:2368516-2368770 [Legionella pneumophila]
ATGACCCGTACAATGACTGTTGATTTGGGTAATGAACTTCGTAATTACGTGGAATCACTTGTACGCTCAGGGGATTATAG
AAGTAATAGCGAAGTATTAAGAGAGTCGTTGCGTTTACTTCGTGAAAAACAAGCTGAATCAAAACTAGAGCAGTTGCGTC
ACCTTATAGATGAAGGGGCAGCTAGCGGGAAGCCTGAAACATGGGATGCACATGATTTTCTTAAGAAAATGAAGAAAAAA
TCCCATGTCAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References