Detailed information of TA system TA061766

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prpT-prpA/CC2985(antitoxin)
• Location: 2368516..2369056
• Replicon: chromosome
• Accession: NZ_CP014760
• Organism: Legionella pneumophila strain F4469

Toxin (Protein)

• Gene name: PrpT
• Uniprot ID: -
• Locus tag: A1D14_RS10905
• Protein ID: WP_014844324.1
• Coordinates: 2368760..2369056 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: PrpA
• Uniprot ID: -
• Locus tag: A1D14_RS10900
• Protein ID: WP_027224835.1
• Coordinates: 2368516..2368770 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A1D14_RS10880	2364420..2365595	-	1176	WP_027224832.1	ISL3 family transposase	-
A1D14_RS10885	2365634..2366764	-	1131	WP_064319116.1	ISL3 family transposase	-
A1D14_RS10890	2366919..2367497	+	579	WP_027224833.1	hypothetical protein	-
A1D14_RS10895	2367602..2368168	+	567	WP_027224834.1	hypothetical protein	-
A1D14_RS10900	2368516..2368770	+	255	WP_027224835.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
A1D14_RS10905	2368760..2369056	+	297	WP_014844324.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A1D14_RS10915	2369517..2370531	-	1015	Protein_2088	transposase	-
A1D14_RS10920	2370794..2371003	+	210	WP_010947832.1	cold-shock protein	-
A1D14_RS10925	2371243..2372649	+	1407	WP_014844326.1	ATP-dependent RNA helicase DbpA	-
A1D14_RS10930	2372806..2373717	+	912	WP_014844327.1	cation diffusion facilitator family transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2300058..2369302	69244

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-94)

Antitoxin

• Antitoxin ParD (1-81)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11582.28 Da
• Isoelectric Point: 7.2728

>T61766 WP_014844324.1 NZ_CP014760:2368760-2369056 [Legionella pneumophila]
MSNKTYRLYPKAVEDLESIYLYSTNEFGIKRTEDYILAIDLSFQRLADDPLIARKCDYIRPELRAFNVGSHIIFFKTTDY
GISVIRVLHQSMDFNRHL

Nucleotide

• Length: 297 bp

>T61766 NZ_CP014760:2368760-2369056 [Legionella pneumophila]
ATGTCAAATAAAACATATCGTCTTTACCCAAAAGCGGTAGAAGATCTTGAGTCCATCTATTTATATAGCACAAATGAGTT
TGGTATCAAACGAACAGAGGATTATATTTTAGCTATAGATTTAAGTTTTCAGCGCCTTGCAGATGATCCCTTAATTGCTC
GAAAATGTGATTATATTCGTCCAGAATTACGCGCATTTAATGTTGGCTCTCACATTATTTTTTTCAAAACTACCGATTAC
GGCATTTCTGTTATTCGAGTGTTGCATCAATCTATGGATTTTAATAGACATCTATAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9786.14 Da
• Isoelectric Point: 9.9613

>AT61766 WP_027224835.1 NZ_CP014760:2368516-2368770 [Legionella pneumophila]
MTRTMTVDLGNELRNYVESLVRSGDYRSNSEVLRESLRLLREKQAESKLEQLRHLIDEGAASGKPETWDAHDFLKKMKKK
SHVK

Nucleotide

• Length: 255 bp

>AT61766 NZ_CP014760:2368516-2368770 [Legionella pneumophila]
ATGACCCGTACAATGACTGTTGATTTGGGTAATGAACTTCGTAATTACGTGGAATCACTTGTACGCTCAGGGGATTATAG
AAGTAATAGCGAAGTATTAAGAGAGTCGTTGCGTTTACTTCGTGAAAAACAAGCTGAATCAAAACTAGAGCAGTTGCGTC
ACCTTATAGATGAAGGGGCAGCTAGCGGGAAGCCTGAAACATGGGATGCACATGATTTTCTTAAGAAAATGAAGAAAAAA
TCCCATGTCAAATAA