Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 68292..69829 Replicon chromosome
Accession NZ_CP014760
Organism Legionella pneumophila strain F4469

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag A1D14_RS00325 Protein ID WP_027224673.1
Coordinates 68292..69590 (-) Length 433 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag A1D14_RS00330 Protein ID WP_014840730.1
Coordinates 69590..69829 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A1D14_RS00295 63777..64496 + 720 WP_014843028.1 C39 family peptidase -
A1D14_RS00300 64532..65092 + 561 WP_011212702.1 hypothetical protein -
A1D14_RS15815 65200..65361 + 162 WP_015444967.1 hypothetical protein -
A1D14_RS00305 65398..65802 - 405 WP_011212703.1 MerR family transcriptional regulator -
A1D14_RS00310 65872..66624 + 753 WP_027224671.1 glutaredoxin family protein -
A1D14_RS00315 66814..67905 + 1092 WP_027224672.1 hypothetical protein -
A1D14_RS00320 67947..68222 + 276 Protein_62 integrase -
A1D14_RS00325 68292..69590 - 1299 WP_027224673.1 HipA domain-containing protein Toxin
A1D14_RS00330 69590..69829 - 240 WP_014840730.1 helix-turn-helix domain-containing protein Antitoxin
A1D14_RS00335 70196..70560 + 365 Protein_65 protein LvrA -
A1D14_RS00340 70670..70942 + 273 WP_032829407.1 hypothetical protein -
A1D14_RS00350 71637..73049 - 1413 WP_027224675.1 hypothetical protein -
A1D14_RS00355 73080..73688 - 609 WP_027224676.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(148-398)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 433 a.a.        Molecular weight: 49473.80 Da        Isoelectric Point: 8.2954

>T61765 WP_027224673.1 NZ_CP014760:c69590-68292 [Legionella pneumophila]
MRKLYILMNNELVGELTQDNAGGLSFSYVADWISKPHSRPVSLSLPLVNQKFSGEVVYNFFDNLLPDNPQIRARIQARFQ
AKSSRPFDLLALIGSDCVGAIQIVERIPQTQRLSIESHVVSEAEIARTLRSYQTSPLGMDKEDDEFRISIAGAQEKTAFL
YYQNEWHKPFGPTPTTHIFKLPIGYLPHQGIDLSESCENEHLCLLLASKFGLDVAKSKILQFEDEKVLVVERFDRKWSRD
NRYILRLPQEDLCQALGYSPNLKYQSDGGPGIKEIMQLLNGSQQPQKDRDEFFRAQVVYWCLGAIDAHAKNFSISIQPQG
GYQLTPLYDIISAYPIVEQKQLSFKKLKMAMALYGKNIHYKIDGIQKRHFIETAKYVKYSKIKAAQIFEQVIDRIDSAID
EVSRQLPNHFPEKIADPIFKGMRAFKERMIST

Download         Length: 1299 bp

>T61765 NZ_CP014760:c69590-68292 [Legionella pneumophila]
ATGCGTAAATTATACATATTGATGAACAATGAGCTCGTGGGGGAGCTTACCCAGGATAATGCAGGTGGTTTGAGTTTTTC
CTACGTTGCTGACTGGATTTCCAAACCGCATTCACGCCCAGTTTCTTTATCGTTACCGTTAGTAAATCAAAAATTTTCAG
GAGAAGTTGTTTATAACTTTTTTGATAATTTACTTCCCGATAATCCACAGATAAGAGCCAGAATTCAAGCTCGTTTTCAG
GCAAAATCATCGCGACCGTTTGATTTATTGGCGTTAATTGGCAGTGATTGTGTTGGTGCAATACAAATTGTTGAACGTAT
TCCTCAGACACAGCGTCTAAGCATTGAAAGTCACGTTGTCAGTGAGGCCGAGATAGCTCGTACTTTACGTTCTTACCAAA
CCTCACCACTGGGAATGGATAAAGAGGATGATGAGTTTAGAATCTCAATAGCCGGTGCTCAGGAAAAAACGGCTTTTCTA
TATTACCAAAATGAATGGCATAAACCATTTGGACCTACACCAACAACTCACATATTCAAATTACCTATTGGATATTTACC
ACATCAAGGAATTGATTTAAGTGAGAGTTGTGAAAATGAGCATCTCTGTTTACTACTAGCCAGCAAATTTGGTTTAGATG
TTGCAAAATCAAAAATCTTACAATTCGAAGATGAAAAAGTGCTGGTTGTCGAAAGATTTGATAGAAAATGGAGTCGAGAT
AACCGTTATATACTCAGGTTACCGCAAGAAGACCTATGCCAAGCGTTGGGTTATTCACCAAATTTAAAATATCAGTCAGA
TGGTGGCCCCGGTATTAAAGAAATTATGCAGCTACTTAATGGCTCACAGCAGCCTCAAAAAGACAGAGATGAATTTTTCA
GAGCACAAGTTGTTTACTGGTGCCTTGGTGCTATTGATGCGCATGCCAAAAATTTCAGTATAAGTATACAACCACAAGGC
GGTTACCAGCTCACCCCCTTATACGACATCATTTCAGCCTATCCTATCGTGGAACAAAAACAGCTATCCTTTAAGAAATT
GAAAATGGCAATGGCTTTATATGGTAAAAATATTCATTACAAGATTGACGGTATTCAAAAAAGACACTTTATTGAAACAG
CAAAATACGTTAAATATTCTAAAATTAAAGCAGCTCAGATTTTTGAACAAGTGATTGACCGTATTGATTCTGCTATCGAT
GAGGTCTCAAGACAATTACCAAACCACTTCCCAGAAAAGATTGCAGATCCAATCTTCAAAGGGATGAGAGCTTTTAAGGA
GCGAATGATATCCACATAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9096.40 Da        Isoelectric Point: 5.0774

>AT61765 WP_014840730.1 NZ_CP014760:c69829-69590 [Legionella pneumophila]
MIISSAKDLALYLNDKRKQLKMSQSEVADLVGLKQDTISKFENSPDNSRIDTLFRILSALNLNMSLVEKDQKTHEEIEW

Download         Length: 240 bp

>AT61765 NZ_CP014760:c69829-69590 [Legionella pneumophila]
ATGATCATTAGCTCAGCAAAAGATTTAGCATTATATTTAAATGACAAGCGCAAACAACTCAAAATGAGTCAATCTGAAGT
TGCCGATTTAGTCGGCTTAAAACAGGATACCATATCAAAGTTTGAAAATAGCCCCGATAATAGTCGAATTGATACCTTAT
TTAGAATATTGTCCGCCCTAAATTTAAATATGAGCCTTGTTGAAAAAGATCAAAAAACTCATGAAGAGATAGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References