Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 3835800..3836443 Replicon chromosome
Accession NZ_CP014755
Organism Klebsiella pneumoniae strain AATZP

Toxin (Protein)


Gene name vagD Uniprot ID A0A4S8C081
Locus tag WM86_RS18700 Protein ID WP_032433387.1
Coordinates 3835800..3836216 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag WM86_RS18705 Protein ID WP_001261276.1
Coordinates 3836213..3836443 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WM86_RS18670 3830969..3831172 - 204 WP_032433376.1 hemolysin expression modulator Hha -
WM86_RS18675 3831232..3831723 - 492 WP_032433378.1 hypothetical protein -
WM86_RS18680 3831754..3832272 - 519 WP_045326794.1 hypothetical protein -
WM86_RS18685 3832331..3832579 - 249 WP_032433382.1 hypothetical protein -
WM86_RS18690 3832898..3834469 + 1572 WP_032433383.1 ATP-binding protein -
WM86_RS18695 3834664..3835644 - 981 WP_032433385.1 hypothetical protein -
WM86_RS18700 3835800..3836216 - 417 WP_032433387.1 type II toxin-antitoxin system VapC family toxin Toxin
WM86_RS18705 3836213..3836443 - 231 WP_001261276.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
WM86_RS18710 3836748..3837563 + 816 WP_032433388.1 hypothetical protein -
WM86_RS18720 3838091..3840331 - 2241 WP_045326788.1 NTPase -
WM86_RS18725 3840334..3841421 - 1088 Protein_3585 transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3806963..3851807 44844


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14974.43 Da        Isoelectric Point: 7.8921

>T61758 WP_032433387.1 NZ_CP014755:c3836216-3835800 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALHLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLTLEDWVI

Download         Length: 417 bp

>T61758 NZ_CP014755:c3836216-3835800 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATTATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACCGACATCCGGGTGGCGCTGCACCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGCCACGCCATCGCGGCGGGCGCCGTCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTGCCTGGACTGACACTGG
AAGACTGGGTTATTTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT61758 WP_001261276.1 NZ_CP014755:c3836443-3836213 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp

>AT61758 NZ_CP014755:c3836443-3836213 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAACGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S8C081

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References